当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Tetravalent neutralizing antibody response against four dengue serotypes by a single chimeric dengue envelope antigen.

Tetravalent neutralizing antibody response against four dengue serotypes by a single chimeric dengue envelope antigen.

Abstract：

:We employed DNA shuffling and screening technologies to develop a single recombinant dengue envelope (E) antigen capable of inducing neutralizing antibodies against all four antigenically distinct dengue serotypes. By DNA shuffling of codon-optimized dengue 1-4 E genes, we created a panel of novel chimeric clones expressing C-terminal truncated E antigens that combined epitopes from all four dengue serotypes. DNA vaccines encoding these novel chimeras induced multivalent T cell and neutralizing antibody responses against all four dengue serotypes in mice. By contrast, a mixture of four unshuffled, parental DNA vaccines failed to produce tetravalent neutralizing antibodies in mice. The neutralizing antibody titers for some of these antigens could be further improved by extending the sequences to express full-length pre-membrane and envelope proteins. The chimeric antigens also protected mice against a lethal dengue-2 virus challenge. These data demonstrate that DNA shuffling and associated screening can lead to the selection of multi-epitope antigens against closely related dengue virus serotypes and suggest a broad utility for these technologies in optimizing vaccine antigens.

journal_name

Vaccine

journal_title

Vaccine

authors

Apt D,Raviprakash K,Brinkman A,Semyonov A,Yang S,Skinner C,Diehl L,Lyons R,Porter K,Punnonen J

doi

10.1016/j.vaccine.2005.07.100

subject

Has Abstract

pub_date

2006-01-16 00:00:00

pages

335-44

issue

3

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)00751-6

journal_volume

24

pub_type

杂志文章

相关文献

VACCINE文献大全
  • WHO Working Group on revision of the Manual of Laboratory Methods for Testing DTP Vaccines-Report of two meetings held on 20-21 July 2006 and 28-30 March 2007, Geneva, Switzerland.

    abstract：:This report reflects the discussion and conclusions of a WHO group of experts from National Regulatory Authorities (NRAs), National Control Laboratories (NCLs), vaccine industries and other relevant institutions involved in standardization and control of diphtheria, tetanus and pertussis vaccines (DTP), held on 20-21 ...

    journal_title：Vaccine

    pub_type：

    doi：10.1016/j.vaccine.2008.02.013

    authors： Corbel MJ,Das RG,Lei D,Xing DK,Horiuchi Y,Dobbelaer R,WHO Working Group.

    更新日期：2008-04-07 00:00:00

  • Targeted expression of HTLV-I envelope proteins in muscle by DNA immunization of mice.

    abstract：:We have compared two types of plasmids for DNA immunization against HTLV-I envelope glycoproteins. One type of plasmid contains the coding DNA of the complete envelope gene of HTLV-I under the control of the CMV promoter with (CMVenvLTR) or without (CMVenv) the tax/rex genes. The second type contains the coding DNA of...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00565-4

    authors： Armand MA,Grange MP,Paulin D,Desgranges C

    更新日期：2000-04-28 00:00:00

  • Passive immunization with llama single-domain antibody fragments reduces foot-and-mouth disease transmission between pigs.

    abstract：:We aim to develop a method that confers rapid protection against foot-and-mouth disease (FMD) by passive immunization with recombinant llama single-domain antibody fragments (VHHs). Previously constructed genetic fusions of two VHHs (VHH2s) that either neutralizes FMDV or binds to porcine immunoglobulin to increase th...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.01.110

    authors： Harmsen MM,Fijten HP,Engel B,Dekker A,Eblé PL

    更新日期：2009-03-18 00:00:00

  • The changing landscape of respiratory syncytial virus.

    abstract：:Recognition of the acute and chronic burden of respiratory syncytial virus (RSV) lower respiratory tract infections (LRTI) sparked a wave of initiatives to develop preventive and therapeutic products against the pathogen in recent years. RSV is a leading cause of hospitalization in infants in industrialized and develo...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2015.06.119

    authors： Polack FP

    更新日期：2015-11-25 00:00:00

  • Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization.

    abstract：:Plasmid DNA vaccines encoding full-length antigen often induce both potent antibody and cytotoxic T lymphocyte (CTL) responses. Here, we examine strategies to exclusively elicit epitope-specific CTL responses using DNA constructs expressing a minimal class I MHC-restricted epitope of the nucleoprotein (NP) of influenz...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(98)00411-3

    authors： Iwasaki A,Dela Cruz CS,Young AR,Barber BH

    更新日期：1999-04-09 00:00:00

  • Independent but not synergistic enhancement to the immunogenicity of DNA vaccine expressing HIV-1 gp120 glycoprotein by codon optimization and C3d fusion in a mouse model.

    abstract：:The ability to elicit humoral and cell-mediated immune (CMI) responses from DNA immunization by combinational use of codon optimization and C3d component of complement was evaluated in this study. DNA vaccines that express either the wild type or the codon optimized gp120 gene coding for the envelope (Env) glycoprotei...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.09.054

    authors： Liu F,Mboudjeka I,Shen S,Chou TH,Wang S,Ross TM,Lu S

    更新日期：2004-04-16 00:00:00

  • Enhanced protection against pneumococcal infection elicited by immunization with the combination of PspA, PspC, and ClpP.

    abstract：:Immunization with a combination of several virulence-associated proteins is one of the strategies of developing effective protein-based vaccines to enhance the protection against Streptococcus pneumoniae. In this study, we evaluated the protection effects against pneumococcal infection caused by S. pneumoniae TIGR4 in...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.04.069

    authors： Cao J,Chen D,Xu W,Chen T,Xu S,Luo J,Zhao Q,Liu B,Wang D,Zhang X,Shan Y,Yin Y

    更新日期：2007-06-28 00:00:00

  • Physical, chemical and immunological stability of CHO-derived hepatitis B surface antigen (HBsAg) particles.

    abstract：:Recombinant hepatitis B surface antigen (HBsAg) particles derived from Chinese hamster ovary (CHO) cells were stored at various conditions for 12-18 months in their naked form or adsorbed to alum (HBV vaccine). The physical, chemical and immunological parameters during storage at -20 degrees C, 4 degrees C, room tempe...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00149-8

    authors： Diminsky D,Moav N,Gorecki M,Barenholz Y

    更新日期：1999-08-20 00:00:00

  • Pandemic preparedness: different perspectives. How ready are we for the next pandemic?

    abstract：:Europe is not ready for the next pandemic. Nonetheless, several positive developments are cause for optimism. The European Centre for Disease Control (ECDC) was founded in May 2005 and has explicitly identified influenza as one of its top four priorities. Europe is also taking steps to streamline the regulatory approv...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.06.066

    authors：

    更新日期：2006-11-10 00:00:00

  • Single chain MHC I trimer-based DNA vaccines for protection against Listeria monocytogenes infection.

    abstract：:To circumvent limitations of poor antigen presentation and immunogenicity of DNA vaccines that target induction of CD8(+) T cell immunity, we have generated single chain MHC I trimers (MHC I SCTs) composed of a single polypeptide chain with a linear composition of antigenic peptide, β2-microglobulin, and heavy chain o...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.01.012

    authors： Kim S,Zuiani A,Carrero JA,Hansen TH

    更新日期：2012-03-09 00:00:00

  • Cost and cost-effectiveness of childhood vaccination against rotavirus in France.

    abstract：OBJECTIVES:To assess the effectiveness and cost-effectiveness of routine childhood vaccination by new vaccines against rotavirus in France. METHODS:We constructed a Markov decision tree to compare two alternatives: "no vaccination" and "vaccination". A hypothetical birth cohort of 750,000 children was followed until 3...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.11.064

    authors： Melliez H,Levybruhl D,Boelle PY,Dervaux B,Baron S,Yazdanpanah Y

    更新日期：2008-01-30 00:00:00

  • Combined DNA vaccine encapsulated in microspheres enhanced protection efficacy against Mycobacterium tuberculosis infection of mice.

    abstract：:In a study to develop novel vaccination strategies against tuberculosis, we encapsulated DNA encoding Ag85B, MPT-64 and MPT-83 antigens mixed with dimethyldioctyldecyl ammonium bromide (DDA) into biodegradable poly(dl-lactide-co-glycolide, PLGA) microspheres. Scanning electron microscopy (SEM) analysis demonstrated a ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.03.024

    authors： Cai H,Hu XD,Yu DH,Li SX,Tian X,Zhu YX

    更新日期：2005-07-14 00:00:00

  • Anti-viral activity of sulfated chitin derivatives against Friend murine leukaemia and herpes simplex type-1 viruses.

    abstract：:Sulfated chitin derivatives, selected for their low toxicity and high inhibitory activity of melanoma metastasis, were examined for anti-viral activity against Friend murine leukaemia, herpes simplex type-1 (HSV) and Sendai viruses. Carboxymethyl chitin with a 7.66% degree of sulfation (SCM-chitin III) showed a signif...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(93)90315-o

    authors： Ishihara C,Yoshimatsu K,Tsuji M,Arikawa J,Saiki I,Tokura S,Azuma I

    更新日期：1993-01-01 00:00:00

  • Packaging limits and stability of HIV-1 sequences in a coxsackievirus B vector.

    abstract：:Enteroviruses elicit protective mucosal immune responses that could be harnessed as part of a strategy to prevent sexual transmission of the human immunodeficiency virus-1 (HIV-1). We report the construction of replication-competent recombinant vectors of coxsackievirus B3 (CVB3) that express one or more portions of t...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.04.035

    authors： Miller JP,Geng Y,Ng HL,Yang OO,Krogstad P

    更新日期：2009-06-19 00:00:00

  • Influenza vaccination coverage among adults with diabetes, United States, 2007-08 through 2017-18 seasons.

    abstract：BACKGROUND:Diabetes is associated with higher risk of hospitalization, morbidity, and mortality from influenza. We assessed influenza vaccination coverage among adults aged ≥ 18 years with diabetes during the 2007-08 through 2017-18 influenza seasons and identified factors independently associated with vaccination duri...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.08.008

    authors： Hung MC,Lu PJ,Srivastav A,Cheng YJ,Williams WW

    更新日期：2020-09-29 00:00:00

  • Early detection and visualization of human adenovirus serotype 5-viral vectors carrying foot-and-mouth disease virus or luciferase transgenes in cell lines and bovine tissues.

    abstract：:Recombinant replication-defective human adenovirus type 5 (Ad5) vaccines containing capsid-coding regions from foot-and-mouth disease virus (FMDV) have been demonstrated to induce effective immune responses and provide homologous protective immunity against FMDV in cattle. However, basic mechanisms of Ad5-FMDV vaccine...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.12.082

    authors： Montiel N,Smoliga G,Arzt J

    更新日期：2012-02-21 00:00:00

  • Effect of thiomersal on dissociation of intact (146S) foot-and-mouth disease virions into 12S particles as assessed by novel ELISAs specific for either 146S or 12S particles.

    abstract：:Intact (146S) foot-and-mouth disease virions (FMDVs) can dissociate into specific (12S) viral capsid degradation products. Using two single-domain antibody fragments that bind specifically to either 146S or 12S particles we developed two ELISAs for the quantification of these particles in FMDV antigen preparations use...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.01.069

    authors： Harmsen MM,Fijten HP,Westra DF,Coco-Martin JM

    更新日期：2011-03-24 00:00:00

  • Immunization of livestock with DNA vaccines: current studies and future prospects.

    abstract：:Early studies using DNA immunization suggest the potential benefits of this form of immunization including: long-lived immunity, a broad spectrum of immune responses (both cell-mediated immunity and humoral responses) and the simultaneous induction of immunity to a variety of pathogens through the use of multivalent v...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00476-x

    authors： van Drunen Littel-van den Hurk S,Loehr BI,Babiuk LA

    更新日期：2001-03-21 00:00:00

  • Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals.

    abstract：:Obesity is a risk factor for complicated influenza A/H1N1 disease and poor vaccine immunogenicity. Leptin, an adipocyte-derived hormone/cytokine, has many immune regulatory functions and therefore could explain susceptibility to infections and poor vaccine outcomes. We recruited 159 healthy adults (50-74 years old) wh...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.12.009

    authors： Ovsyannikova IG,White SJ,Larrabee BR,Grill DE,Jacobson RM,Poland GA

    更新日期：2014-02-07 00:00:00

  • Overcoming the knowledge-behavior gap: The effect of evidence-based HPV vaccination leaflets on understanding, intention, and actual vaccination decision.

    abstract：OBJECTIVE:Informed decision making requires transparent and evidence-based (=balanced) information on the potential benefit and harms of medical preventions. An analysis of German HPV vaccination leaflets revealed, however, that none met the standards of balanced risk communication. METHODS:We surveyed a sample of 225...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.12.038

    authors： Wegwarth O,Kurzenhäuser-Carstens S,Gigerenzer G

    更新日期：2014-03-10 00:00:00

  • A systematic review and meta-analysis on the safety of newly adjuvanted vaccines among children.

    abstract：INTRODUCTION:New adjuvants such as the AS- or the MF59-adjuvants improve vaccine efficacy and facilitate dose-sparing. Their use in influenza and malaria vaccines has resulted in a large body of evidence on their clinical safety in children. METHODS:We carried out a systematic search for safety data from published cli...

    journal_title：Vaccine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.vaccine.2015.12.024

    authors： Stassijns J,Bollaerts K,Baay M,Verstraeten T

    更新日期：2016-02-03 00:00:00

  • Evaluating functional antibodies in rhesus monkeys immunized with hepatitis B virus surface antigen vaccine with novel adjuvant formulations.

    abstract：:Effective and safe novel adjuvants are of great interest to the vaccine research community. In this study, we describe our evaluation of adjuvant formulations containing a TLR9 agonist adjuvant (ISS1018) or ISCOMATRIX™ adjuvant for a two-dose regimen of hepatitis B virus surface antigen virus-like particle vaccine in ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.09.122

    authors： Freed DC,Towne VM,Casimiro DR,Zhao Q,Fu TM

    更新日期：2011-11-21 00:00:00

  • Pertussis immunization in paediatric healthcare workers: knowledge, attitudes, beliefs, and behaviour.

    abstract：:Healthcare workers' (HCWs) knowledge, attitudes, and beliefs regarding pertussis immunization were assessed and compared to the rate of vaccine uptake. A questionnaire was distributed to employees at a paediatric and maternity tertiary care centre. Respondents were then offered a dose of the tetanus, diphtheria, and a...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.12.060

    authors： Top KA,Halperin BA,Baxendale D,MacKinnon-Cameron D,Halperin SA

    更新日期：2010-03-02 00:00:00

  • Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp.

    abstract：:In chronic Hepatitis B Virus (HBV) infection the function of dendritic cells (DC), T- and B-cells is impaired. DC vaccination is an option to overcome this. DC pulsed in vitro with HBV sub viral particles (HBVsvp) and used to immunize mice can activate HBV directed humoral and cellular immune responses. In the present...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.07.057

    authors： Farag MM,Tedjokusumo R,Flechtenmacher C,Asen T,Stremmel W,Müller M,Protzer U,Weigand K

    更新日期：2012-09-14 00:00:00

  • Optimal approaches to data collection and analysis of potential immune mediated disorders in clinical trials of new vaccines.

    abstract：BACKGROUND:The potential for development of autoimmune diseases after vaccination with new vaccines containing novel adjuvants is a theoretical concern. Randomised, placebo-controlled trials are the best method for assessing a potential causal relationship between an adverse event and vaccination, but usually have a sa...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.01.042

    authors： Tavares Da Silva F,De Keyser F,Lambert PH,Robinson WH,Westhovens R,Sindic C

    更新日期：2013-04-03 00:00:00

  • Does influenza vaccination improve pregnancy outcome? Methodological issues and research needs.

    abstract：:Evidence that influenza vaccination during pregnancy is safe and effective at preventing influenza disease in women and their children through the first months of life is increasing. Several reports of reduced risk of adverse outcomes associated with influenza vaccination have generated interest in its potential for i...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2015.08.041

    authors： Savitz DA,Fell DB,Ortiz JR,Bhat N

    更新日期：2015-11-25 00:00:00

  • Vaccination markers: designing unique antigens to be added to vaccines to differentiate between natural infection and vaccination.

    abstract：:Some important vaccines, including ones against tuberculosis (Tb) and foot-and-mouth disease (FMD), are not used in many developed countries because there is no simple way to differentiate between vaccine-induced immunity and infection. Eliminating major protein antigens has not succeeded in the cases of Tb, FMD and s...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2005.01.008

    authors： Root-Bernstein RS

    更新日期：2005-03-18 00:00:00

  • Potentiation of an anthrax DNA vaccine with electroporation.

    abstract：:DNA vaccines are a promising method of immunization against biothreats and emerging infections because they are relatively easy to design, manufacture, store and distribute. However, immunization with DNA vaccines using conventional delivery methods often fails to induce consistent, robust immune responses, especially...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.03.064

    authors： Luxembourg A,Hannaman D,Nolan E,Ellefsen B,Nakamura G,Chau L,Tellez O,Little S,Bernard R

    更新日期：2008-09-19 00:00:00

  • Human airway epithelial cells present antigen to influenza virus-specific CD8+ CTL inefficiently after incubation with viral protein together with ISCOMATRIX.

    abstract：:In the present paper, an in vitro model was established in which the interaction between influenza virus-specific CD8+ T cells and human airway epithelial cells can be studied. To this end, the human lung epithelial cell line A549 was transduced with the HLA-A*0201 gene. This MHC class I allele is involved in the pres...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.01.052

    authors： Rimmelzwaan GF,Boon AC,Geelhoed-Mieras MM,Voeten JT,Fouchier RA,Osterhaus AD

    更新日期：2004-07-29 00:00:00

  • Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials.

    abstract：BACKGROUND:Efforts to develop a Clostridium difficile vaccine are underway; identification of patients at risk for C. difficile infection (CDI) is critical to inform vaccine trials. We identified groups at high risk of CDI ≥ 2 8 days after hospital discharge. METHODS:Hospital discharge data and pharmacy data from two ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.09.078

    authors： Baggs J,Yousey-Hindes K,Ashley ED,Meek J,Dumyati G,Cohen J,Wise ME,McDonald LC,Lessa FC

    更新日期：2015-11-17 00:00:00