Vaccination markers: designing unique antigens to be added to vaccines to differentiate between natural infection and vaccination.

Abstract:

:Some important vaccines, including ones against tuberculosis (Tb) and foot-and-mouth disease (FMD), are not used in many developed countries because there is no simple way to differentiate between vaccine-induced immunity and infection. Eliminating major protein antigens has not succeeded in the cases of Tb, FMD and some other vaccine preparations. Instead of eliminating antigens, novel antigens can be added to vaccines in order to induce a unique immunological response proving that the vaccine has been delivered. Methods for producing such unique antigens are presented and preliminary test results reported. The technique may also be useful for immunologically "branding" animals.

journal_name

Vaccine

journal_title

Vaccine

authors

Root-Bernstein RS

doi

10.1016/j.vaccine.2005.01.008

subject

Has Abstract

pub_date

2005-03-18 00:00:00

pages

2057-9

issue

17-18

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)00009-5

journal_volume

23

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Inducing systemic and mucosal immune responses to B-T construct of F1 antigen of Yersinia pestis in microsphere delivery.

    abstract::Plague is a zoonotic disease caused by Yersinia pestis, an etiological agent of pneumonic and bubonic plague. There is a need for an improved plague vaccine that may overcome the limitation of presently available whole cell vaccine. An alternative approach described here, is the use of protective epitopes from immunod...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2006.01.031

    authors: Tripathi V,Chitralekha KT,Bakshi AR,Tomar D,Deshmukh RA,Baig MA,Rao DN

    更新日期:2006-04-12 00:00:00

  • Epidermal powder immunization against influenza.

    abstract::Epidermal powder immunization (EPI) can efficiently deliver powdered protein vaccines to the epidermis. A phase I clinical trial was conducted to evaluate powdered trivalent influenza vaccine delivered using the PowderJect ND5.2 delivery system. Subjects received either Fluvirin IM injection (15 microg of each influen...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.vaccine.2004.06.041

    authors: Dean HJ,Chen D

    更新日期:2004-12-16 00:00:00

  • Intramuscular delivery of a cholera DNA vaccine primes both systemic and mucosal protective antibody responses against cholera.

    abstract::Cholera is a potentially lethal diarrhea disease caused by the gram-negative bacterium Vibrio cholerae. The need for an effective cholera vaccine is clearly indicated but the challenges of eliciting both systemic and mucosal immune responses remains a significant challenge. In the current report, we discovered that a ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2009.04.008

    authors: Xu G,Wang S,Zhuang L,Hackett A,Gu L,Zhang L,Zhang C,Wang H,Huang Z,Lu S

    更新日期:2009-06-12 00:00:00

  • Disparities in parental human papillomavirus (HPV) vaccine awareness and uptake among adolescents.

    abstract::Trends in HPV vaccine awareness among parents of adolescent girls and boys (ages 13-17) and HPV vaccine uptake (≥1 dose) among girls (ages 13-17) were evaluated in Los Angeles County, California. Between 2007 and 2011, parental HPV vaccine awareness increased from 72% to 77% overall, with significant increases among m...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2017.08.046

    authors: Nonzee NJ,Baldwin SB,Cui Y,Singhal R

    更新日期:2018-02-28 00:00:00

  • Sustained impact of rotavirus vaccine introduction on rotavirus gastroenteritis hospitalizations in children

    abstract:INTRODUCTION:Ghana introduced monovalent rotavirus vaccine in April 2012. We sought to determine the long-term impact of routine rotavirus vaccination on rotavirus gastroenteritis hospitalizations in Ghana during the first 4 years following rotavirus vaccine introduction. METHODS:Active sentinel surveillance for acute...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2018.02.058

    authors: Enweronu-Laryea CC,Armah G,Sagoe KW,Ansong D,Addo-Yobo E,Diamenu SK,Mwenda JM,Parashar UD,Tate JE

    更新日期:2018-11-12 00:00:00

  • Positive role for rApxIVN in the immune protection of pigs against infection by Actinobacillus pleuropneumoniae.

    abstract::The role of in vivo-induced ApxIV toxin of Actinobacillus pleuropneumoniae in protective immunity was evaluated in pigs by administering it alone or added to a multicomponent recombinant subunit vaccine composed of recombinant ApxI, ApxII, ApxIII toxin, and 42-kDa outer membrane protein (OMP). The pigs were immunized ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2009.07.065

    authors: Wang C,Wang Y,Shao M,Si W,Liu H,Chang Y,Peng W,Kong X,Liu S

    更新日期:2009-09-25 00:00:00

  • Influenza vaccination of future healthcare workers: a cross-sectional study of uptake, knowledge and attitudes.

    abstract::Promotional campaigns recommend immunisation against influenza in healthcare workers (HCWs) but the uptake in this group remains low. We conducted a survey study during the 2008-2009 influenza vaccination period amongst future HCWs to quantify uptake and identify barriers to immunisation. Overall uptake was 8.0% (95% ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2010.04.066

    authors: Blank DL,Bodansky DM,Forbes A,Garde E,Story F,Roalfe AK,Tait L

    更新日期:2010-06-23 00:00:00

  • The impact of parental postpartum pertussis vaccination on infection in infants: A population-based study of cocooning in Western Australia.

    abstract::During a pertussis epidemic in 2011-2012 the Western Australian (WA) Department of Health implemented a 'cocooning' programme, offering free pertussis-containing vaccine (dTpa) to new parents. We assessed the impact of vaccinating parents with dTpa on the incidence of pertussis infection in newborns. Births in WA duri...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2015.08.066

    authors: Carcione D,Regan AK,Tracey L,Mak DB,Gibbs R,Dowse GK,Bulsara M,Effler PV

    更新日期:2015-10-13 00:00:00

  • Innate immunemodulator containing adjuvant formulated HA based vaccine protects mice from lethal infection of highly pathogenic avian influenza H5N1 virus.

    abstract::The highly pathogenic avian influenza (HPAI) H5N1 viruses and their spillover into the human population pose substantial economic and public health threats. Although antiviral drugs have some effect in treating influenza infection, vaccination is still the most effective intervention to prevent possible pandemic outbr...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2020.01.051

    authors: Lu Y,Landreth S,Liu G,Brownlie R,Gaba A,Littel-van den Hurk SVD,Gerdts V,Zhou Y

    更新日期:2020-02-28 00:00:00

  • Randomized comparison of the safety of Flublok(®) versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥ 50 years of age.

    abstract:BACKGROUND:The safety and tolerability of Flublok(®), a purified recombinant hemagglutinin seasonal influenza vaccine, was compared to AFLURIA(®) in a randomized, blinded clinical trial in adults ≥ 50 years of age with attention to hypersensitivity reactions. METHODS:This blinded, randomized trial of healthy adults ≥ ...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.vaccine.2015.10.097

    authors: Izikson R,Leffell DJ,Bock SA,Patriarca PA,Post P,Dunkle LM,Cox MM

    更新日期:2015-11-27 00:00:00

  • Protective immunity against herpes simplex virus generated by DNA vaccination compared to natural infection.

    abstract::To evaluate the utility of plasmid DNA vaccination against disease caused by herpes simplex virus (HSV), we compared the strength of protection against lethal challenge following natural virus infection with that following vaccination with a plasmid encoding HSV glycoprotein gD (gD-DNA). We further determined the cell...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(00)00380-7

    authors: Nass PH,Elkins KL,Weir JP

    更新日期:2001-01-08 00:00:00

  • Expansion of syndromic vaccine preventable disease surveillance to include bacterial meningitis and Japanese encephalitis: evaluation of adapting polio and measles laboratory networks in Bangladesh, China and India, 2007-2008.

    abstract:BACKGROUND:Surveillance for acute flaccid paralysis with laboratory confirmation has been a key strategy in the global polio eradication initiative, and the laboratory platform established for polio testing has been expanded in many countries to include surveillance for cases of febrile rash illness to identify measles...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2015.01.004

    authors: Cavallaro KF,Sandhu HS,Hyde TB,Johnson BW,Fischer M,Mayer LW,Clark TA,Pallansch MA,Yin Z,Zuo S,Hadler SC,Diorditsa S,Hasan AS,Bose AS,Dietz V,AMES Study Group.

    更新日期:2015-02-25 00:00:00

  • Propagation of Brazilian Zika virus strains in static and suspension cultures using Vero and BHK cells.

    abstract::The recent spread of Zika virus (ZIKV) in the Americas and the Pacific has reached alarming levels in more than 60 countries. However, relatively little is known about the disease on a virological and epidemiological level and its consequences for humans. Accordingly, a large demand for in vitro derived Brazilian ZIKV...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2017.03.018

    authors: Nikolay A,Castilho LR,Reichl U,Genzel Y

    更新日期:2018-05-24 00:00:00

  • Impact of the National Perinatal Hepatitis B Prevention Programme in the Republic of Korea: A retrospective registry-based cohort study.

    abstract:INTRODUCTION:Hepatitis B is a major preventable cause of morbidity and mortality from chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. We aimed to evaluate the performance and outcomes of the Korean Perinatal Hepatitis B Prevention Programme (PHBPP) and to investigate the impact of the current post-exp...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2020.05.044

    authors: Yang TU,Jung CW,Kim D,Park HA,Jee Y

    更新日期:2020-07-22 00:00:00

  • Effect of low level immunity on response to live rubella virus vaccine.

    abstract::Serum specimens of 1075 young adults representing nursing and medical staff were collected for determination of rubella immunity using the radial haemolysis (RH) technique, also know as the haemolysis in gel (HIG) test. Of the sera 84 (7.8%) were negative (RH titre less than 4 mm) and an additional 93 (8.7%) gave an R...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(86)90090-3

    authors: Väänänen P,Mäkelä P,Vaheri A

    更新日期:1986-03-01 00:00:00

  • Ten-year follow-up study of neonatal hepatitis B immunization: are booster injections indicated?

    abstract::One hundred and fourteen children, born to HBsAg-positive mothers received in the first year of life passive active prophylaxis for hepatitis B virus (HBV). They have been followed up to 10 years. A booster dose given in a cohort at the 5th year does not seem to increase protection against HBV. No difference in immuno...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(97)00028-5

    authors: Resti M,Azzari C,Mannelli F,Rossi ME,Lionetti P,Vierucci A

    更新日期:1997-08-01 00:00:00

  • Development of an oral vaccine for immunisation of rainbow trout (Oncorhynchus mykiss) against viral haemorrhagic septicaemia.

    abstract::In the European Union Viral Haemorrhagic Septicaemia (VHS) eradication is still based on stamping out. Due to the lack of effective low cost vaccines immune prophylaxis is currently not used to combat VHS. This paper describes a new oral delivery method for immunisation of trout with attenuated virus. The vaccine cons...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2007.11.065

    authors: Adelmann M,Köllner B,Bergmann SM,Fischer U,Lange B,Weitschies W,Enzmann PJ,Fichtner D

    更新日期:2008-02-06 00:00:00

  • Catalase immunization from Pseudomonas aeruginosa enhances bacterial clearance in the rat lung.

    abstract::Pseudomonas aeruginosa is a common cause of infection in immunocompromised patients and is the major contributor to morbidity in individuals with cystic fibrosis (CF). The antibiotic resistance shown by this pathogen and morbidity in patients with chronic infection has encouraged investigations into the development of...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(00)00146-8

    authors: Thomas LD,Dunkley ML,Moore R,Reynolds S,Bastin DA,Kyd JM,Cripps AW

    更新日期:2000-09-15 00:00:00

  • Frequency and erroneous usage of temporary medical exemptions and knowledge of immunization guidelines among some Miami-Dade County Florida providers.

    abstract:OBJECTIVE:We assessed knowledge and practices regarding immunization guidelines and the Florida Certificate of Immunization (DH-680) based on FL-DOH and CDC recommendations, to identify the cause of the increasing number of erroneously issued temporary medical exemptions (TME) among selected health care providers in Mi...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2014.06.041

    authors: Cruze AR,Zhang G,Thomas L,Alonso J,Sandoval L

    更新日期:2014-07-31 00:00:00

  • Potential T cell epitopes within swine-origin triple reassortant influenza A (H3N2) variant virus which emerged in 2011: an immunoinformatics study.

    abstract::An immuno-informatics study was conducted to determine possible pre-existing T cellular immunity to the recently emerged swine-origin triple reassortant H3N2 variant (S-OtrH3N2v-2011) which acquired the matrix gene of influenza A (H1N1)pdm09. Given the genetic origin of S-OtrH3N2v-2011, our study focused on the hemagg...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2012.07.054

    authors: Duvvuri VR,Marchand-Austin A,Eshaghi A,Patel SN,Low DE,Gubbay JB

    更新日期:2012-09-14 00:00:00

  • Post-licensure safety surveillance of 23-valent pneumococcal polysaccharide vaccine in the Vaccine Adverse Event Reporting System (VAERS), 1990-2013.

    abstract:BACKGROUND:23-Valent pneumococcal polysaccharide vaccine, trade name Pneumovax(®)23 (PPSV23), has been used for decades in the Unites States and has an extensive clinical record. However, limited post-licensure safety assessment has been conducted. OBJECTIVE:To analyze reports submitted to the Vaccine Adverse Event Re...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2016.04.021

    authors: Miller ER,Moro PL,Cano M,Lewis P,Bryant-Genevier M,Shimabukuro TT

    更新日期:2016-05-27 00:00:00

  • Myxomavirus as a vector for the immunisation of sheep: protection study against challenge with bluetongue virus.

    abstract::Recombinant poxviruses are well suited for the development of new vaccine vectors. Our previous data supported the idea that Myxomavirus (MYXV) is efficient at priming antibody responses in sheep. To provide definitive evidence on the potential of MYXV for vaccination against infectious diseases in ruminants, we inves...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2011.12.108

    authors: Top S,Foucras G,Deplanche M,Rives G,Calvalido J,Comtet L,Bertagnoli S,Meyer G

    更新日期:2012-02-21 00:00:00

  • Comparative biological activities of whole cell pertussis vaccine and a new acellular preparation.

    abstract::The biological activities of whole-cell pertussis vaccine and a new acellular preparation were compared. It was observed that both preparations were similarly effective in inducing protection in mice against intracerebral challenge with B. pertussis, however, the acellular preparation was approximately 200-fold more p...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章

    doi:10.1016/0264-410x(85)90005-2

    authors: García-Sánz JA,Ruiz-Puente J,Jiménez-Paredes J,González-Pacheco M,Villalva-Posada H

    更新日期:1985-03-01 00:00:00

  • Effective mucosal immunization against respiratory syncytial virus using purified F protein and a genetically detoxified cholera holotoxin, CT-E29H.

    abstract::We exploited the powerful adjuvant properties of cholera holotoxin (CT) to create a mucosally administered subunit vaccine against respiratory syncytial virus (RSV). A genetically detoxified mutant CT with an E to H substitution at amino acid 29 of the CT-A1 subunit (CT-E29H) was compared to wild type CT for toxicity ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(00)00058-x

    authors: Tebbey PW,Scheuer CA,Peek JA,Zhu D,LaPierre NA,Green BA,Phillips ED,Ibraghimov AR,Eldridge JH,Hancock GE

    更新日期:2000-06-01 00:00:00

  • Nef modulates the immunogenicity of Gag encoded in a non-infectious HIV DNA vaccine.

    abstract::Gag-CD8+ T cell responses are associated with immune control of HIV infection. Since during HIV infection Nef impairs T cell responses, we evaluated whether deletion of nef from a non-infectious HIV DNA vaccine (Delta4 Nef+), creating Delta5 Nef(-), would affect its immunogenicity. When compared with Delta4, mice inje...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2008.05.057

    authors: Arrode G,Hegde R,Jin Y,Singh DK,Narayan O,Chebloune Y

    更新日期:2008-07-23 00:00:00

  • Intragastric immunization with recombinant Lactobacillus casei expressing flagellar antigen confers antibody-independent protective immunity against Salmonella enterica serovar Enteritidis.

    abstract::A recombinant Lactobacillus casei expressing a flagellar antigen from Salmonella enterica serovar Enteritidis was constructed and evaluated as a mucosal vaccine. Intragastric immunization of the recombinant strain conferred protective immunity against Salmonella infection in mice. This immunization did not result in a...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2007.01.055

    authors: Kajikawa A,Satoh E,Leer RJ,Yamamoto S,Igimi S

    更新日期:2007-05-04 00:00:00

  • Expression of cytokine genes following pre- and post-hatch immunization of chickens with herpesvirus of turkeys.

    abstract::Induction of immune response as characterised by expression of cytokine genes in the spleen following immunization of pre- and post-hatch chickens with herpesvirus of turkeys (HVT) vaccine was studied. The pattern of expression of IFN-gamma and IL-10 genes in pre-hatch immunized chickens was different from that observ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2008.02.069

    authors: Abdul-Careem MF,Hunter DB,Lambourne MD,Read LR,Parvizi P,Sharif S

    更新日期:2008-05-02 00:00:00

  • Effective adjuvants for the induction of antigen-specific delayed-type hypersensitivity.

    abstract::Vaccines utilizing poorly immunogenic subunit antigens are dependent upon adjuvants to drive the appropriate T cell responses. In an effort to determine the ability of several adjuvants to promote cell-mediated immunity (CMI), we assessed delayed-type hypersensitivity (DTH) in mice inoculated with heat-killed Listeria...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(96)00199-5

    authors: Baldridge JR,Ward JR

    更新日期:1997-03-01 00:00:00

  • A DNA vaccine targeting the receptor-binding domain of Clostridium difficile toxin A.

    abstract::Clostridium difficile is a pathogen with increasing severity for which host antibody responses provide protection from disease. DNA vaccination has several advantages compared to traditional vaccine methods, however no study has examined this platform against C. difficile toxins. A synthetic gene was created encoding ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2009.03.058

    authors: Gardiner DF,Rosenberg T,Zaharatos J,Franco D,Ho DD

    更新日期:2009-06-02 00:00:00

  • Novel modifications to the C-terminus of LTB that facilitate site-directed chemical coupling of antigens and the development of LTB as a carrier for mucosal vaccines.

    abstract::To facilitate site-directed chemical coupling of antigens to the heat labile enterotoxin B subunit of Escherichia coli (LTB), a series of genetically modified fusion proteins of LTB were constructed. The LTB fusion proteins had modified versions of a short (14 amino acid) spacer epitope called the Pk tag attached at t...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(98)00375-2

    authors: O'Dowd AM,Botting CH,Precious B,Shawcross R,Randall RE

    更新日期:1999-03-17 00:00:00