Abstract：
:Epidermal powder immunization (EPI) can efficiently deliver powdered protein vaccines to the epidermis. A phase I clinical trial was conducted to evaluate powdered trivalent influenza vaccine delivered using the PowderJect ND5.2 delivery system. Subjects received either Fluvirin IM injection (15 microg of each influenza strain), a single EPI vaccination (15 microg of each influenza strain) or two adjacent EPI (total of 30 microg of each influenza strain). Systemic reactogenicity was similar between control and EPI vaccines. Site reactions following EPI were primarily mild and self-limiting. Seroconversions, titer increases and geometric mean titers to all strains were equivalent or higher in EPI-immunized groups than in controls. Powdered influenza vaccine delivered by EPI is safe and elicits humoral immune responses in humans.
journal_name
Vaccinejournal_title
Vaccineauthors
Dean HJ,Chen Ddoi
10.1016/j.vaccine.2004.06.041subject
Has Abstractpub_date
2004-12-16 00:00:00pages
681-6issue
5eissn
0264-410Xissn
1873-2518pii
S0264-410X(04)00530-4journal_volume
23pub_type
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