Abstract:
:Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula that affects sheep, cattle, goats, camels, and humans. Effective vaccination of susceptible ruminants is important for the prevention of RVF outbreaks. Live-attenuated RVF vaccines are in general highly immunogenic in ruminants, whereas residual virulence might be a concern for vulnerable populations. It is also important for live-attenuated strains to encode unique genetic markers for the differentiation from wild-type RVFV strains. In this study, we aimed to strengthen the attenuation profile of the MP-12 vaccine strain via the introduction of 584 silent mutations. To minimize the impact on protective efficacy, codon usage and codon pair bias were not de-optimized. The resulting rMP12-GM50 strain showed 100% protective efficacy with a single intramuscular dose, raising a 1:853 mean titer of plaque reduction neutralization test. Moreover, outbred mice infected with one of three pathogenic reassortant ZH501 strains, which encoded rMP12-GM50 L-, M-, or S-segments, showed 90%, 50%, or 30% survival, respectively. These results indicate that attenuation of the rMP12-GM50 strain is significantly attenuated via the L-, M-, and S-segments. Recombinant RVFV vaccine strains encoding similar silent mutations will be also useful for the surveillance of reassortant strains derived from vaccine strains in endemic countries.
journal_name
Vaccinejournal_title
Vaccineauthors
Ly HJ,Nishiyama S,Lokugamage N,Smith JK,Zhang L,Perez D,Juelich TL,Freiberg AN,Ikegami Tdoi
10.1016/j.vaccine.2017.10.036subject
Has Abstractpub_date
2017-12-04 00:00:00pages
6634-6642issue
48 Pt Beissn
0264-410Xissn
1873-2518pii
S0264-410X(17)31444-5journal_volume
35pub_type
杂志文章相关文献
VACCINE文献大全abstract::Patients with malignancies are considered to be at increased risk of acquiring influenza. Because of higher complication and case fatality rates, preventive measures such as vaccination are of great interest. The objective of this study was to assess the acceptability, tolerability and immunogenicity of an adjuvant-fr...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.09.005
更新日期:2012-11-06 00:00:00
abstract::In anticipation of the implementation of new prophylactic HPV vaccines, the WHO is supporting the establishment of a global WHO HPV Laboratory Network whose mission is to "contribute to improving the quality of laboratory services for effective surveillance and monitoring of HPV vaccination impact through enhanced, st...
journal_title:Vaccine
pub_type:
doi:10.1016/j.vaccine.2008.10.062
更新日期:2009-01-14 00:00:00
abstract::Based on the reactivities of monoclonal antibodies, we previously reported that 25 Japanese encephalitis (JE) virus strains fell into five antigenic groups: Nakayama, Beijing-1, Kamiyama, 691004 and Muar. In the present study, we produced monoclonal antibodies against the Beijing-1 strain and obtained the Beijing-1 gr...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(94)90222-4
更新日期:1994-06-01 00:00:00
abstract::We recently described the use of ion exchange chromatography for analysis and the industrial scale preparation of pools of oligosaccharides of intermediate chain length from polysaccharides of Haemophilus influenzae type b (Hib) and Neisseria meningitidis groups A and C. These negatively charged "sized" oligosaccharid...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(99)00092-4
更新日期:1999-07-16 00:00:00
abstract::Gavi, the Vaccine Alliance, supports immunisation programmes in eligible countries to reach children with lifesaving vaccines. Dramatic improvement in the scale and performance of current cold chain systems is required to extend the reach of immunisation services - especially for children living in remote locations - ...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2016.12.073
更新日期:2017-04-19 00:00:00
abstract::The potential for smallpox to be disseminated in a bioterror attack has prompted development of new, safer smallpox vaccination strategies. We designed and evaluated immunogenicity and efficacy of a T-cell epitope vaccine based on conserved and antigenic vaccinia/variola sequences, identified using bioinformatics and ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.10.064
更新日期:2011-01-10 00:00:00
abstract::Adult patients with mucosal leishmaniasis (ML) were enrolled in a randomized, double-blind, placebo-controlled, dose-escalating clinical trial and were randomly assigned to receive three injections of either the LEISH-F1+MPL-SE vaccine (consisting of 5, 10, or 20 μg recombinant Leishmania polyprotein LEISH-F1 antigen+...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2010.08.092
更新日期:2010-10-28 00:00:00
abstract:INTRODUCTION:The WHO recommends annual influenza vaccination to prevent influenza illness in high-risk groups. Little is known about national influenza immunization policies globally. MATERIAL AND METHODS:The 2014 WHO/UNICEF Joint Reporting Form (JRF) on Immunization was adapted to capture data on influenza immunizati...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2016.07.045
更新日期:2016-10-26 00:00:00
abstract:BACKGROUND:The safety and tolerability of Flublok(®), a purified recombinant hemagglutinin seasonal influenza vaccine, was compared to AFLURIA(®) in a randomized, blinded clinical trial in adults ≥ 50 years of age with attention to hypersensitivity reactions. METHODS:This blinded, randomized trial of healthy adults ≥ ...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.vaccine.2015.10.097
更新日期:2015-11-27 00:00:00
abstract::We recently reported an attenuated EIAV vaccine study that directly examined the effect of lentiviral envelope sequence variation on vaccine efficacy. The study [1] demonstrated for the first time the failure of an ancestral vaccine to protect and revealed a significant, inverse, linear relationship between envelope d...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.10.003
更新日期:2010-11-29 00:00:00
abstract::Schmallenberg virus (SBV), which emerged in 2011 in Central Europe and subsequently spread very rapidly throughout the continent, affects predominantly ruminants. SBV is transmitted by insect vectors, and therefore vaccination is one of the major tools of disease control. Only recently, a domain connected to virus neu...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.07.047
更新日期:2018-08-16 00:00:00
abstract::An economic evaluation of reducing the age threshold for routine influenza vaccination in Spain from 65 to 50 years was performed. A probabilistic model was used to compare a policy based on a recommendation to vaccinate all adults aged 50-64 with the existing vaccination policy for that age group, during interpandemi...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2007.07.033
更新日期:2007-09-28 00:00:00
abstract::Pneumococcal meningitis in the African meningitis belt is primarily caused by Streptococcus pneumoniae serotype 1, a serotype contained in the 13-valent pneumococcal conjugate vaccine (PCV13). In 2014, Niger introduced PCV13 with doses given at 6, 10, and 14 weeks of age. We leveraged existing meningitis surveillance ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.04.009
更新日期:2020-05-13 00:00:00
abstract::110 children who were given the complete course of the inactivated hepatitis A vaccine (Havrix) were followed up 10 years later. Age-matched healthy children who were not inoculated served as controls. One month after two primary injections, all children were positive for serum antibody. After 10 years, 99.09% of inoc...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.04.096
更新日期:2010-07-05 00:00:00
abstract::Recently, it was discovered that sialic acid residues on group B streptococcal (GBS) capsular polysaccharides (CPS) are O-acetylated. Since GBS vaccine development has focused on de-O-acetylated CPS, it became germane to investigate the influence of de-O-acetylated GBS vaccine formulations on functional activity of se...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.05.039
更新日期:2009-07-16 00:00:00
abstract::Although the USA is considered an area of 'low' endemicity for hepatitis B infection, the incidence of new cases, the prevalence of carriers, and the burden of acute and chronic disease place hepatitis B among the most important communicable diseases. It is estimated that 300,000 new cases of hepatitis B infection occ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(95)80040-k
更新日期:1995-01-01 00:00:00
abstract::Immunization of boars against GnRH inhibits synthesis of testicular anabolic steroids and the sex odour androstenone. Time between second vaccination and return of Leydig cell function is unknown. Six catheterized boars received the second dose (Improvac) at 26 weeks of age (day 0). Titre, LH, testicular steroids, and...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.05.085
更新日期:2008-08-18 00:00:00
abstract::General vaccination with the 7-valent pneumococcal conjugate vaccine was recommended in Germany in July 2006 for all children <2 years. The proportion of reported invasive pneumococcal disease (IPD) caused by vaccine serotypes before vaccine introduction was considerably lower than in the US. We report data from natio...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.04.057
更新日期:2009-06-24 00:00:00
abstract::Various peptide-based approaches to simultaneous induction of multiple cytotoxic T lymphocyte (CTL) responses were evaluated as part of ongoing efforts to develop immunotherapeutic vaccines for use in humans. To this end, HLA (human histocompatibility leukocyte antigen)-A2-restricted epitopes from several specific vir...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(97)00264-8
更新日期:1998-05-01 00:00:00
abstract::Malaria remains an important health threat to non-immune travelers with the explosive growth of global travel. Populations at high risk of acquiring malaria infections include once semi-immune travelers who visit friends and relatives, military forces, business travelers and international tourists with destinations to...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.10.004
更新日期:2015-12-22 00:00:00
abstract:BACKGROUND:Vaccinations have been suggested to be associated with increased risk of allergic diseases. Tetanus vaccination is one of the most frequently administered vaccines as a part of wound management and was also found to be associated with increased serum IgE levels. We hypothesized that the vaccination modifies ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2016.10.068
更新日期:2016-12-12 00:00:00
abstract:BACKGROUND:Household-based caregivers serve an important role in protecting the health of cancer patients, who may be vulnerable to infectious diseases due to their cancer treatments. Caregiver preventive care should be prioritized to maintain continuity of care and to reduce potential for transmission of infectious di...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.07.052
更新日期:2020-09-11 00:00:00
abstract::Vaccines prevent an estimated 2.5 million deaths worldwide each year and are amongst the most cost-effective preventive measures against infectious diseases. Despite the effectiveness and availability of vaccines in many parts of the world, vaccination rates and service uptake remains suboptimal among both healthcare ...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2019.08.060
更新日期:2019-09-20 00:00:00
abstract::Two hundred and fifty children born in 1967 and vaccinated with killed polio vaccine in Sweden were followed for 18 years and tested for neutralizing antibodies against polio. All of them had demonstrable antibodies at the age of 18. Sixty-four children were tested in samples collected throughout the years. After a mo...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(90)90244-g
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Although the mortality from diarrheal diseases has been decreasing dramatically in Iran, it still represents an important proportion of disease burden in children <5 years old. Rotavirus vaccines are among the most effective strategies against diarrheal diseases in specific epidemiological conditions. This s...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.12.035
更新日期:2015-05-07 00:00:00
abstract::The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines. In this context, maternally immune conventional layer chickens were vaccinated in ovo with a turkey herpe...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.10.049
更新日期:2010-01-08 00:00:00
abstract::Numerous evidence demonstrate Type 1 diabetes (T1D) is due to a loss of immune tolerance to islet antigens, and CD8(+) T cells play an important role in the development of T1D in NOD mice. The novel coinhibitory receptor BTLA may have a regulatory role in maintaining peripheral tolerance, however, its role in autoimmu...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.07.125
更新日期:2011-10-13 00:00:00
abstract::Influenza A virus causes respiratory tract infections, which are occasionally complicated by secondary bacterial infections. Influenza A virus replicates in epithelial cells and leukocytes resulting in the production of chemokines and cytokines, which favor the extravasation of blood mononuclear cells and the developm...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/s0264-410x(00)00275-9
更新日期:2000-12-08 00:00:00
abstract:BACKGROUND:As part of a series of feasibility studies following the development of Canadian vaccine barcode standards, we compared barcode scanning with manual methods for entering vaccine data into electronic client immunization records in public health settings. METHODS:Two software vendors incorporated barcode scan...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.11.015
更新日期:2014-05-13 00:00:00
abstract:BACKGROUND:In response to a cholera outbreak among mobile, difficult-to-reach fishermen on Lake Chilwa, Malawi in 2016, a novel vaccine distribution strategy exploited the proven vaccine thermostability. Fishermen, while taking the first vaccine dose under supervision, received the second dose in a sealed bag, and were...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.05.044
更新日期:2019-06-19 00:00:00