Abstract：
:We recently reported an attenuated EIAV vaccine study that directly examined the effect of lentiviral envelope sequence variation on vaccine efficacy. The study [1] demonstrated for the first time the failure of an ancestral vaccine to protect and revealed a significant, inverse, linear relationship between envelope divergence and protection from disease. In the current study we examine in detail the evolution of the attenuated vaccine strain utilized in this previous study. We demonstrate here that the attenuated strain progressively evolved during the six-month pre-challenge period and that the observed protection from disease was significantly associated with divergence from the original vaccine strain.
journal_name
Vaccinejournal_title
Vaccineauthors
Craigo JK,Barnes S,Cook SJ,Issel CJ,Montelaro RCdoi
10.1016/j.vaccine.2010.10.003subject
Has Abstractpub_date
2010-11-29 00:00:00pages
8095-104issue
51eissn
0264-410Xissn
1873-2518pii
S0264-410X(10)01462-3journal_volume
28pub_type
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