当前位置： SCI文献检索 > VACCINE期刊下所有文献 > The MHC-haplotype influences primary, but not memory, immune responses to an immunodominant peptide containing T- and B-cell epitopes of the caprine arthritis encephalitis virus Gag protein.

The MHC-haplotype influences primary, but not memory, immune responses to an immunodominant peptide containing T- and B-cell epitopes of the caprine arthritis encephalitis virus Gag protein.

Abstract：

:In this report, we describe a short peptide, containing a T helper- and a B-cell epitope, located in the Gag protein of the caprine arthritis encephalitis virus (CAEV). This T-cell epitope is capable of inducing a robust T-cell proliferative response in vaccinated goats with different genetic backgrounds and to provide help for a strong antibody response to the B-cell epitope, indicating that it may function as a universal antigen-carrier for goat vaccines. The primary immune response of goats homozygous for MHC class I and II genes showed an MHC-dependent partitioning in rapid-high and slow-low responses, whereas the memory immune response was strong in both groups, demonstrating that a vaccine based on this immunodominant T helper epitope is capable to overcome genetic differences.

journal_name

Vaccine

journal_title

Vaccine

authors

Fluri A,Nenci C,Zahno ML,Vogt HR,Charan S,Busato A,Pancino G,Peterhans E,Obexer-Ruff G,Bertoni G

doi

10.1016/j.vaccine.2005.08.043

subject

Has Abstract

pub_date

2006-01-30 00:00:00

pages

597-606

issue

5

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)00848-0

journal_volume

24

pub_type

杂志文章

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