Abstract：
:All patients with congenital clotting disorders attending our centre routinely receive hepatitis B vaccination. We have assessed retrospectively the vaccine responses in 167 such individuals, with a follow-up period of up to 7.5 years. The initial postvaccine anti-HBs response was lower in older patients (p = 0.001), those infected with human immunodeficiency virus (HIV) (p = 0.05), and those who received intradermal rather than subcutaneous administration of vaccine (p = 0.08). It was estimated that the median time for anti-HBs levels to fall to 100 IU l-1 was between 36 and 42 months, with a shorter period for older or HIV-infected patients. Although the persistence of protective antibody levels can be predicted to some extent from the absolute levels of initial postvaccine anti-HBs, the wide variation in antibody decline between individuals precludes recommendation of the timing of vaccine booster doses solely based on this value.
journal_name
Vaccinejournal_title
Vaccineauthors
Pillay D,Pereira C,Sabin C,Powell L,Zuckerman AJ,Lee CAdoi
10.1016/0264-410x(94)90331-xsubject
Has Abstractpub_date
1994-08-01 00:00:00pages
978-83issue
11eissn
0264-410Xissn
1873-2518pii
0264-410X(94)90331-Xjournal_volume
12pub_type
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