Sequence constancies and variations in genes encoding three new meningococcal vaccine candidate antigens.

abstract：:In 2004, we conducted a study in Piemonte (Italy), in order to describe incidence, treatment, hospitalizations and costs of herpes zoster (HZ), in population over 14 years of age. Twenty-four regional general practitioners, with 26,394 patients >14 years in charge (0.71% of the regional population), reported prospecti...

journal_title：Vaccine

authors： Di Legami V,Gianino MM,Ciofi degli Atti M,Massari M,Migliardi A,Tomba GS,Zotti C,Zoster Study Group.

更新日期：2007-10-23 00:00:00

abstract：:Former investigations demonstrated that the envelope glycoprotein E2 could protect pigs from classical swine fever virus (CSFV). Based on these findings, we prepared synthetic peptide vaccine using E2 N-terminal antigenic units B/C and hoped to induce protective activity against lethal challenge of virulent CSFV strai...

journal_title：Vaccine

authors： Dong XN,Wei K,Liu ZQ,Chen YH

更新日期：2002-12-13 00:00:00

abstract：:Francisella tularensis is the intracellular bacterial pathogen causing the respiratory life-threatening disease tularemia. Development of tularemia vaccines has been hampered by an incomplete understanding of the correlates of immunity. Moreover, the importance of lung cellular immunity in vaccine-mediated protection ...

journal_title：Vaccine

authors： Bar-On L,Cohen H,Elia U,Rotem S,Bercovich-Kinori A,Bar-Haim E,Chitlaru T,Cohen O

更新日期：2017-12-15 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a major respiratory pathogen responsible for severe pulmonary disease. We have developed a parenterally administered vaccine, BBG2Na, which is currently in a phase III clinical trial. BBG2Na comprises residues 130--230 of RSV-A G protein (G2Na) fused to the BB carrier protein. In t...

journal_title：Vaccine

authors： Goetsch L,Plotnicky-Gilquin H,Aubry JP,De-Lys P,Haeuw JF,Bonnefoy JY,Nguyen NT,Corvaïa N,Velin D

更新日期：2001-07-16 00:00:00

abstract：OBJECTIVES:Yearly vaccination against influenza is currently recommended to patients with rheumatoid Arthritis (RA). Antibody and cell-mediated responses are both involved in the defense against influenza. Humoral responses to influenza vaccine are impaired in RA patients treated with rituximab (RTX). The objectives of...

journal_title：Vaccine

authors： Arad U,Tzadok S,Amir S,Mandelboim M,Mendelson E,Wigler I,Sarbagil-Maman H,Paran D,Caspi D,Elkayam O

更新日期：2011-02-11 00:00:00

abstract：:The frequent outbreak of respiratory infectious diseases such as influenza and pulmonary tuberculosis calls for new immunization strategies with high effectiveness. Nasal immunization is one of the most potential methods to prevent the diseases infected through the respiratory tract. In this study, we designed a water...

journal_title：Vaccine

authors： Liu Q,Zhang C,Zheng X,Shao X,Zhang X,Zhang Q,Jiang X

更新日期：2014-05-07 00:00:00

abstract：:Two outbreaks of hepatitis A started almost simultaneously in a maternal school and in a day care centre located at opposite sides of Florence, Italy, at the end of 2002. Both of them originated from immigrant children, and in both cases, hepatitis A was initially not recognised due to aspecific symptoms. While vaccin...

journal_title：Vaccine

authors： Bonanni P,Franzin A,Staderini C,Pitta M,Garofalo G,Cecconi R,Santini MG,Lai P,Innocenti B

更新日期：2005-03-18 00:00:00

abstract：BACKGROUND:Immunization with pneumococcal vaccines is an important prophylactic strategy for children with asplenia or splenic dysfunction, who are at high risk of bacterial infections (including S. pneumoniae). This study aimed to assess immunogenicity and safety of pneumococcal non-typeable Haemophilus influenzae pro...

journal_title：Vaccine

authors： Szenborn L,Osipova IV,Czajka H,Kharit SM,Jackowska T,François N,Habib MA,Borys D

更新日期：2017-09-25 00:00:00

abstract：:In 2005, in accordance with recommendations made by the European Medicines Agency, the Italian Drug Agency ordered withdrawal of the hexavalent Hexavac(®) vaccine (Sanofi Pasteur MSD) from the market. Concerns had been raised about the low immunogenicity of the hepatitis B virus component of the vaccine, assessed by m...

journal_title：Vaccine

authors： Carollo M,Palazzo R,Bianco M,Pandolfi E,Chionne P,Fedele G,Tozzi AE,Carsetti R,Romanò L,Ausiello CM

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:Long-term immunosuppressive medications are being used more commonly for a variety of medical conditions, including immune-mediated diseases and organ transplantation. While these medications are often necessary, they are associated with an increased risk of serious infections. Vaccination may be a way to pr...

journal_title：Vaccine

authors： Agarwal N,Ollington K,Kaneshiro M,Frenck R,Melmed GY

更新日期：2012-02-14 00:00:00

abstract：:Fertile turkey eggs after 24 days of incubation were vaccinated in ovo with a commercial live attenuated subtype A avian pneumovirus (APV) vaccine. Hatchability was not adversely affected. When a high dose (10 times maximum commercial dose) of vaccine was tested in maternal antibody negative (MA-) eggs, mild clinical ...

journal_title：Vaccine

authors： Worthington KJ,Sargent BA,Davelaar FG,Jones RC

更新日期：2003-03-28 00:00:00

abstract：:Estimation of the full disease burden caused by Streptococcus pneumoniae is challenging due to the difficulties in assigning the aetiology especially in lower and upper respiratory infections. We estimated the pneumococcal disease burden by using the vaccine-preventable disease incidence (VPDI) of PHiD-CV10 vaccine (G...

journal_title：Vaccine

authors： Palmu AA,Jokinen J,Nieminen H,Rinta-Kokko H,Ruokokoski E,Puumalainen T,Moreira M,Schuerman L,Borys D,Kilpi TM

更新日期：2018-03-27 00:00:00

abstract：:Rabies is one of the most lethal infectious diseases in the world, with a mortality approaching 100%. There are between 60,000 and 70,000 reported annual deaths, but this is probably an underestimation. Despite the fact that there are vaccines available for rabies, there is a real need of developing more efficacious a...

journal_title：Vaccine

authors： Fontana D,Kratje R,Etcheverrigaray M,Prieto C

更新日期：2015-08-20 00:00:00

abstract：:Whole killed meningococci (Nm) and pertussis bacteria (Bp) were tested for mucosal immunogenicity and as mucosal adjuvants for an inactivated influenza virus vaccine given intranasally to unanaesthetized mice. Virus was given alone, or simply mixed with one of the bacterial preparations, in four doses at weekly interv...

journal_title：Vaccine

authors： Berstad AK,Andersen SR,Dalseg R,Dromtorp S,Holst J,Namork E,Wedege E,Haneberg B

更新日期：2000-03-17 00:00:00

abstract：:Technology transfer is a promising approach to increase vaccine production at an affordable price in developing countries. In the case of influenza, it is imperative that developing countries acquire the technology to produce pandemic vaccines through the transfer of know-how, as this will be the only way for the majo...

journal_title：Vaccine

authors： Miyaki C,Meros M,Precioso AR,Raw I

更新日期：2011-07-01 00:00:00

abstract：:The effectiveness of the influenza vaccine used in the 2001-2002 influenza season in Japan was investigated in a large-scale, geographically widely distributed, Internet-based study. Data were collected from 8841 of 9902 subjects registered by 38 clinics prior to the start of influenza season. Subjects were categorize...

journal_title：Vaccine

authors： Kawai N,Ikematsu H,Iwaki N,Satoh I,Kawashima T,Tsuchimoto T,Kashiwagi S

更新日期：2003-11-07 00:00:00

abstract：:Human chorionic gonadotropin (hCG) is currently under investigation as an antigenic target in both anti-cancer and anti-fertility vaccines. Formulations studied to date show promise in clinical trials for both applications yet are expensive to produce and require frequented administration in order to maintain an effec...

journal_title：Vaccine

authors： Rock EP,Reich KA,Lyu DM,Hovi M,Hardy J,Schoolnik GK,Stocker BA,Stevens V

更新日期：1996-11-01 00:00:00

abstract：:The immunoscreening of Brugia malayi adult cDNA library with pooled endemic normal sera identified several seroreactive clones including, EC-SOD which contained a 612 bp insert and showed significant nucleotide and deduced amino acid sequence homologies with superoxide dismutase (SOD) of other nematode parasites. The ...

journal_title：Vaccine

authors： Dabir S,Dabir P,Goswami K,Reddy MV

更新日期：2008-07-04 00:00:00

abstract：:We recently reported that administration of low doses of myotoxins at vaccination sites potentiated antigen-specific T-cell immunity induced by genetic cancer vaccines in mice, an effect which was superior to TLR agonists. In the current study, we found unexpectedly that the mechanism of this potent adjuvant effect wa...

journal_title：Vaccine

authors： Qin H,Cha SC,Neelapu SS,Liu C,Wang YH,Wei J,Qin XF,Liu YJ,Kwak LW

更新日期：2010-11-23 00:00:00

abstract：:Viral hepatitis remains a major contributor to the global disease burden. Mass immunisation strategies against hepatitis B have been adopted by more than 90 developing and industrialised countries. Countries with low hepatitis A endemicity are experiencing cyclical outbreaks and an epidemiological shift, with larger n...

journal_title：Vaccine

authors： Lopalco PL,Salleras L,Barbuti S,Germinario C,Bruguera M,Buti M,Domínguez A

更新日期：2000-10-15 00:00:00

abstract：:A systematic review was performed to assess the safety and immunogenicity of the prepandemic H5N1 influenza vaccines licensed so far. A bibliographic search according to the COSI protocol was carried out and 8 of 235 potentially relevant publications were selected. Quality assessment was defined with both CASP and Jad...

journal_title：Vaccine

authors： Prieto-Lara E,Llanos-Méndez A

更新日期：2010-06-11 00:00:00

abstract：BACKGROUND:Following a recommendation by the World Health Organization, Madagascar introduced rotavirus vaccine in 2014. Though national rotavirus vaccine coverage has remained <80%, rotavirus hospitalizations declined by 78%. Gavi, the Vaccine Alliance, has provided financial support for rotavirus vaccine, however the...

journal_title：Vaccine

authors： Burnett E,Rahajamanana VL,Raboba JL,Weldegebriel G,Vuo Masembe Y,Mwenda JM,Parashar UD,Tate JE,Robinson AL

更新日期：2020-11-03 00:00:00

abstract：:The immunopotentiating activities of colloidal iron hydroxide, a novel, experimental mineral adjuvant, and of aluminium hydroxide. the licensed adjuvant for human vaccines, were compared. Our studies revealed that colloidal iron hydroxide and aluminium hydroxide behaved comparably with respect to supporting induction ...

journal_title：Vaccine

authors： Leibl H,Tomasits R,Brühl P,Kerschbaum A,Eibl MM,Mannhalter JW

更新日期：1999-03-05 00:00:00

abstract：:This study was designed to determine the impact of maternal HIV-1 specific immunity on HIV-DNA immunization of 2-week-old pups during the breast-feeding period. Adult female mice received intranasal or intradermal HIV-DNA (gp160Env, p37Gag, Nef, Tat and Rev) prime and recombinant protein boost immunizations, which ind...

journal_title：Vaccine

authors： Bråve A,Johansen K,Palma P,Benthin R,Hinkula J

更新日期：2008-11-05 00:00:00

abstract：:The effect of passively transferred RSV immune serum on the antibody response to a single dose of purified RSV fusion (F) and large (G) glycoproteins was studied in cotton rats. Passively transferred antibody that achieved serum antibody levels similar to those seen in newborn human infants resulted in a seven- to eig...

journal_title：Vaccine

authors： Murphy BR,Prince GA,Collins PL,Hildreth SW,Paradiso PR

更新日期：1991-03-01 00:00:00

abstract：:We have compared two types of plasmids for DNA immunization against HTLV-I envelope glycoproteins. One type of plasmid contains the coding DNA of the complete envelope gene of HTLV-I under the control of the CMV promoter with (CMVenvLTR) or without (CMVenv) the tax/rex genes. The second type contains the coding DNA of...

journal_title：Vaccine

authors： Armand MA,Grange MP,Paulin D,Desgranges C

更新日期：2000-04-28 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common cause of serious acute lower respiratory illness in infants and young children and a significant cause of disease burden in the elderly and immunocompromised. There are no licensed RSV vaccines to address this significant public health need. While advances in vaccin...

journal_title：Vaccine

authors： Roberts JN,Graham BS,Karron RA,Munoz FM,Falsey AR,Anderson LJ,Marshall V,Kim S,Beeler JA

更新日期：2016-09-22 00:00:00

abstract：:Cell culture-based manufacturing of influenza vaccines is ideally based on easily scalable platforms using suspension cells that grow in chemically defined media. Consequently, different adherent cell lines selected for high virus yields were adapted to grow in suspension culture. This includes the MDCK suspension cel...

journal_title：Vaccine

authors： Peschel B,Frentzel S,Laske T,Genzel Y,Reichl U

更新日期：2013-11-19 00:00:00

abstract：:Strict age limits for receipt of rotavirus vaccines and simultaneous use of vaccines requiring two (Rotarix(®)) and three (RotaTeq(®)) doses in Australia may impact on coverage and timeliness of other vaccines in the infant schedule. Using data from the Australian Childhood Immunisation Register (ACIR), coverage and t...

journal_title：Vaccine

authors： Hull BP,Menzies R,Macartney K,McIntyre PB

更新日期：2013-04-08 00:00:00

abstract：:We report the results of the handsearch of all the issues of Vaccine from 1983 to 1994 to identify randomized and controlled clinical trials (RCTs and CCTs) with the aim of setting up a Cochrane data base of vaccine trials. We read 1119 original papers and located 231 trials of which 117 (50.6%) were RCTs and 114 (49....

journal_title：Vaccine

authors： Jefferson T,Jefferson V

更新日期：1996-04-01 00:00:00