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Vaccination against hepatitis A during outbreaks starting in schools: what can we learn from experiences in central Italy?

Abstract：

:Two outbreaks of hepatitis A started almost simultaneously in a maternal school and in a day care centre located at opposite sides of Florence, Italy, at the end of 2002. Both of them originated from immigrant children, and in both cases, hepatitis A was initially not recognised due to aspecific symptoms. While vaccination of contacts started with delay in the first outbreak, the same intervention was organised and performed in 3 days in the other. The outbreak starting in the maternal school caused 30 notified cases, plus 7 cases diagnosed retrospectively. Nine of them were in a secondary school, where vaccination (in accordance with the Italian national guidelines on hepatitis A (HA) vaccination) had been started only after a secondary case occurred. Only three cases occurred overall in the other outbreak starting in the day care centre, where >80% of infants, children and personnel were immunised. Although few asymptomatic infections probably occurred, no source of contagion existed any longer 2 months after immunisation. A rapid vaccination of school and family contacts of hepatitis A cases after the first case (irrespective of school grade) seems to play an important role to shorten outbreak duration.

journal_name

Vaccine

journal_title

Vaccine

authors

Bonanni P,Franzin A,Staderini C,Pitta M,Garofalo G,Cecconi R,Santini MG,Lai P,Innocenti B

doi

10.1016/j.vaccine.2005.01.044

subject

Has Abstract

pub_date

2005-03-18 00:00:00

pages

2176-80

issue

17-18

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(05)00047-2

journal_volume

23

pub_type

杂志文章

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