Abstract：
:A pilot study compared the immune response of regular (0, 3, 6, 32 weeks) and extended (0, 10, 13, 32 weeks) schedules of the UK anthrax vaccine (anthrax vaccine precipitated, AVP). Concentrations of antibodies to protective antigen (PA) were higher (p<0.05) among recipients of the extended (n=7) versus regular schedule (n=6) at week 32, and 2 weeks after the second and third vaccinations. Toxin neutralisation assay levels and anti-lethal factor antibodies followed patterns similar to anti-PA antibodies. Extending the interval between the first two AVP vaccinations may produce a stronger immune response, but persistence of this effect needs further study.
journal_name
Vaccinejournal_title
Vaccineauthors
Hepburn MJ,Hugh Dyson E,Simpson AJ,Brenneman KE,Bailey N,Wilkinson L,Hornby R,Mateczun AJ,Bell MG,Baillie LWdoi
10.1016/j.vaccine.2007.05.018subject
Has Abstractpub_date
2007-08-10 00:00:00pages
6089-97issue
32eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)00583-Xjournal_volume
25pub_type
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