Abstract：
:A transplantable hepatocarcinoma of strain 2 guinea pigs was used as an experimental model for immunotherapy of cancer. 6,6'-Dideoxy-6,6'-bis-mycoloylamino-alpha,alpha- trehalose (TDNM) was found to be more effective in producing regression of transplantable line-10 tumours than 6,6'-di-O-mycoloyl-alpha,alpha-trehalose (TDM) when combined with 6-O-stearoyl muramyldipeptide (L18-MDP). TDNM showed potent antitumour activity in combination with synthetic lipid A of Escherichia coli (compound 506), but not with the lipid A analogues (GLA-59 and 60). As with the combination of MDP derivative and lipid A analogue, MDP derivatives conjugated with GLA-60 (GMD compounds) showed no tumour regression activity of line-10 cells in guinea-pigs.
journal_name
Vaccinejournal_title
Vaccineauthors
Ishida H,Saiki I,Saito S,Hasegawa A,Kiso M,Azuma Idoi
10.1016/0264-410x(88)90146-6subject
Has Abstractpub_date
1988-10-01 00:00:00pages
440-4issue
5eissn
0264-410Xissn
1873-2518pii
0264-410X(88)90146-6journal_volume
6pub_type
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