Abstract:
:Although RTS,S remains the most advanced malaria vaccine, the factors influencing differences in vaccine immunogenicity or efficacy between individuals or populations are still poorly characterised. The analyses of genetic determinants of immunogenicity have previously been restricted by relatively small sample sizes from individual trials. Here we combine data from six Phase II RTS,S trials and evaluate the relationship between HLA allele groups and RTS,S-mediated protection in controlled human malaria infections (CHMI), using multivariate logistic or linear regression. We observed significant associations between three allele groups (HLA-A∗01, HLA-B∗08, and HLA-DRB1∗15/∗16) and protection, while another three allele groups (HLA-A∗03, HLA-B∗53, and HLA-DRB1∗07) were significantly associated with lack of protection. It is noteworthy that these 'protective' allele groups are thought to be at a lower prevalence in sub-Saharan African populations than in the UK or USA where these Phase II trials occurred. Taken together, the analyses presented here give an indication that HLA genotype may influence RTS,S-mediated protective efficacy against malaria infection.
journal_name
Vaccinejournal_title
Vaccineauthors
Nielsen CM,Vekemans J,Lievens M,Kester KE,Regules JA,Ockenhouse CFdoi
10.1016/j.vaccine.2018.01.069subject
Has Abstractpub_date
2018-03-14 00:00:00pages
1637-1642issue
12eissn
0264-410Xissn
1873-2518pii
S0264-410X(18)30142-7journal_volume
36pub_type
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