当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Efficacy study of a new albumin-free human diploid cell rabies vaccine (Lyssavac-HDC, Berna) in 100 severely rabies-exposed Thai patients.

Efficacy study of a new albumin-free human diploid cell rabies vaccine (Lyssavac-HDC, Berna) in 100 severely rabies-exposed Thai patients.

Abstract：

:A newly developed human diploid cell rabies vaccine (Lyssavac-HDC), produced without added serum albumin and with an effort to remove the virus-inactivating beta-propriolactone prior to addition of the gelatin, L-cysteine and potassium phosphate stabilizer, was tested for safety immunogenicity, adverse reactions and efficacy in 100 severely rabies-exposed Thais. All patients also received human rabies immune globulin and vaccine was administered using the conventional 5-dose intramuscular schedule of one dose on days 0, 3, 7, 14 and 28. One hundred percent of a subgroup of 40 subjects, where blood had been collected, had neutralizing antibodies greater than 0.5 IU ml-1 on days 28 and 90 and all had detectable titers on days 7, 14, 28, 90, 180 and 360. All patients could be followed for at least 1 year and remained well. No significant side-effects from this vaccine were noted.

journal_name

Vaccine

journal_title

Vaccine

authors

Wilde H,Glueck R,Khawplod P,Cryz SJ,Tantawichien T,Thipkong P,Chomchey P,Prakongsri S,Benjavongkulchai M,Sumboonanondha A

doi

10.1016/0264-410x(94)00049-s

subject

Has Abstract,Author List Incomplete

pub_date

1995-04-01 00:00:00

pages

593-6

issue

6

eissn

0264-410X

issn

1873-2518

pii

0264410X9400049S

journal_volume

13

pub_type

临床试验,杂志文章

相关文献

VACCINE文献大全
  • Seroprevalence of poliovirus antibodies amongst children in Zaria, Northern Nigeria.

    abstract：BACKGROUND:Poliomyelitis is endemic in Northern Nigeria where there is continuous transmission of wild poliovirus 1 and 3 (WPV1 and 3) and circulating vaccine derived poliovirus 2 (cVDPV2) resulting in a high number of cases of children with acute flaccid paralysis. The seroprevalence of antibodies to polio serotypes w...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.09.023

    authors： Giwa FJ,Olayinka AT,Ogunshola FT

    更新日期：2012-11-06 00:00:00

  • Formalin-inactivated bovine RSV vaccine enhances a Th2 mediated immune response in infected cattle.

    abstract：:Safe RSV vaccine development has challenged the medical community since a formalin-killed RSV vaccine caused disease exacerbation in the 1960s. Disease was replicated using the bovine RSV system in one of two studies. The studies differed in viral protein dose and length of time between vaccination and infection. Dise...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.10.024

    authors： Kalina WV,Woolums AR,Berghaus RD,Gershwin LJ

    更新日期：2004-03-29 00:00:00

  • A phase I evaluation of inactivated influenza A/H5N1 vaccine administered by the intradermal or the intramuscular route.

    abstract：:In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28 days apart of an inactivated, subvirion vaccine containing 15 or 45microg of influenza A/H5N1 hemagglutinin (HA) by the intramuscular (IM) route, or 3 or 9microg of H5 HA by the intradermal(ID) route. Seventy-seven su...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2009.10.152

    authors： Patel SM,Atmar RL,El Sahly HM,Cate TR,Keitel WA

    更新日期：2010-04-09 00:00:00

  • Comparison of in vitro and in vivo methods to study stability of PLGA microencapsulated tetanus toxoid vaccines.

    abstract：:The purpose of this study was to investigate the utility of various in vitro and in vivo methods to assess the stability of experimental vaccines containing tetanus toxoid (TT) within PLGA microspheres. In vitro, the breakdown of the encapsulating polymers into their acid components led to changes in the structure of ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00266-8

    authors： Sasiak AB,Bolgiano B,Crane DT,Hockley DJ,Corbel MJ,Sesardic D

    更新日期：2000-11-22 00:00:00

  • Threshold cost-effectiveness analysis for a therapeutic vaccine against HPV-16/18-positive cervical intraepithelial neoplasia in the Netherlands.

    abstract：:In this study, the potential price for a therapeutic vaccine against Human Papilloma Virus (HPV)-16 & 18 (pre)-malignant cervical lesions is examined. A decision tree model was built in the context of the new Dutch cervical cancer-screening program and includes a primary test for the presence of HPV. Based on data of ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.10.019

    authors： Luttjeboer J,Setiawan D,Cao Q,Cahh Daemen T,Postma MJ

    更新日期：2016-12-07 00:00:00

  • Antibodies against Haemophilus influenzae type b in The Gambia: investigating the extent of protection across age groups.

    abstract：:Following a landmark clinical trial, the vaccine against Haemophilus influenzae type b (Hib) was introduced in The Gambia in 1997. Whilst the immunogenicity of this vaccine is well established subsequent to the doses administered under the EPI schedule, little data exists assessing longevity of protection, using serol...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.06.078

    authors： Idoko OT,Roberts E,Cox M,Jafali J,Njie-Jobe J,Mackenzie G,Ota MO,Kampmann B

    更新日期：2014-08-06 00:00:00

  • Mucosal immunization with a replication-deficient adenovirus vector expressing murine cytomegalovirus glycoprotein B induces mucosal and systemic immunity.

    abstract：:The murine cytomegalovirus (MCMV) glycoprotein B (gB) gene was expressed in an adenovirus replication-deficient vector. This virus, designated Ad-gB, was used to immunize BALB/c and B6 mice by the intranasal (i.n.) route to induce an immune response. Following primary immunization, antibody was detected in serum of 10...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(03)00037-9

    authors： Shanley JD,Wu CA

    更新日期：2003-06-02 00:00:00

  • Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction.

    abstract：:Nitric oxide (NO) mediated mechanisms have been implicated in killing of some life-stages of Brugia malayi/Wuchereria bancrofti and protect the host through type 1 responses and IFN-γ stimulated toxic mediators' release. However, the identity of NO stimulating molecules of the parasites is not known. Three predominant...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.11.041

    authors： Verma SK,Joseph SK,Verma R,Kushwaha V,Parmar N,Yadav PK,Thota JR,Kar S,Murthy PK

    更新日期：2015-01-15 00:00:00

  • Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study.

    abstract：INTRODUCTION:We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season. METHODS:We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were co...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.vaccine.2012.07.006

    authors： Puig-Barberà J,Díez-Domingo J,Arnedo-Pena A,Ruiz-García M,Pérez-Vilar S,Micó-Esparza JL,Belenguer-Varea A,Carratalá-Munuera C,Gil-Guillén V,Schwarz-Chavarri H

    更新日期：2012-08-24 00:00:00

  • National surveillance of invasive pneumococcal diseases in Taiwan, 2008-2012: differential temporal emergence of serotype 19A.

    abstract：INTRODUCTION:Serotype replacement after the introduction of seven-valent pneumococcal conjugate vaccine (PCV7) and the future availability of multivalent PCVs prompted the listing of invasive pneumococcal disease (IPD) as a notifiable disease in Taiwan in October 2007. Here, we report the national surveillance results....

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.04.061

    authors： Chiang CS,Chen YY,Jiang SF,Liu DP,Kao PH,Teng HJ,Kuo TL,Yao SM,Tseng LR,Wang YL,Wu HS,Chang FY,Lin TY

    更新日期：2014-06-05 00:00:00

  • Beneficiary characteristics and vaccinations in the end-stage renal disease Medicare beneficiary population, an analysis of claims data 2006-2015.

    abstract：BACKGROUND:The Advisory Committee on Immunization Practices (ACIP) routinely recommends three vaccines - influenza, hepatitis B, and pneumococcal vaccines - for End-Stage Renal Disease (ESRD) dialysis patients. METHODS:We sought to assess vaccination coverage among fee-for-service (FFS) Medicare beneficiaries with ESR...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.10.105

    authors： Shen AK,Kelman JA,Warnock R,Zhang W,Brereton S,McKean S,Wernecke M,Chu S,Gellin BG

    更新日期：2017-12-19 00:00:00

  • Cost-effectiveness of childhood rotavirus vaccination in Taiwan.

    abstract：OBJECTIVE:Rotavirus is the most common cause of severe diarrhea in children. Two rotavirus vaccines (RotaTeq and Rotarix) have been licensed in Taiwan. We have investigated whether routine infant immunization with either vaccine could be cost-effective in Taiwan. METHODS:We modeled specific disease outcomes including ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.01.023

    authors： Wu CL,Yang YC,Huang LM,Chen KT

    更新日期：2009-03-04 00:00:00

  • The use of sequence analysis of a feline calicivirus (FCV) hypervariable region in the epidemiological investigation of FCV related disease and vaccine failures.

    abstract：:A reverse transcriptase polymerase chain reaction (PCR) was used to amplify a 235 bp hypervariable region of the feline calicivirus (FCV) genome which encodes part of the capsid protein. Sequence from this region was used to compare viruses used in three attenuated vaccines to viruses isolated from vaccinated cats wit...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00059-5

    authors： Radford AD,Bennett M,McArdle F,Dawson S,Turner PC,Glenn MA,Gaskell RM

    更新日期：1997-08-01 00:00:00

  • Vaccine coverage and adherence to EPI schedules in eight resource poor settings in the MAL-ED cohort study.

    abstract：BACKGROUND:Launched in 1974, the Expanded Program on Immunization (EPI) is estimated to prevent two-three million deaths annually from polio, diphtheria, tuberculosis, pertussis, measles, and tetanus. Additional lives could be saved through better understanding what influences adherence to the EPI schedule in specific ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.11.075

    authors： Hoest C,Seidman JC,Lee G,Platts-Mills JA,Ali A,Olortegui MP,Bessong P,Chandyo R,Babji S,Mohan VR,Mondal D,Mahfuz M,Mduma ER,Nyathi E,Abreu C,Miller MA,Pan W,Mason CJ,Knobler SL,MAL-ED Network Investigators.

    更新日期：2017-01-11 00:00:00

  • Evaluation of immune response to recombinant potential protective antigens of Mycoplasma hyopneumoniae delivered as cocktail DNA and/or recombinant protein vaccines in mice.

    abstract：:Intramuscular immunization of mice with DNA cocktail vaccines, comprising potential protective antigens P36, P46, NrdF, and P97or P97R1 of Mycoplasma hyopneumoniae, induced strong Th1-polarized immune responses against each antigen, with only P46 eliciting a serum IgG response. Subcutaneous immunization with protein c...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.06.005

    authors： Chen AY,Fry SR,Daggard GE,Mukkur TK

    更新日期：2008-08-12 00:00:00

  • Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization.

    abstract：:Antibodies to the epitope EFRH, representing residues 3-6 within the beta-amyloid (Abeta) sequence, were previously shown to affect the solubility and disaggregation of Abeta fibrils in vitro. Here, we describe a novel method of immunization, using as antigen the EFRH peptide displayed on the surface of the filamentou...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00609-6

    authors： Frenkel D,Dewachter I,Van Leuven F,Solomon B

    更新日期：2003-03-07 00:00:00

  • HIV subtypes and recombination strains--strategies for induction of immune responses in man.

    abstract：:Clinical and experimental studies of HIV-1 subcomponents were made in order to increase their immunogenicity. HIV subtype envelopes A, B and C have been compared and a detailed analysis made by peptides of the coreceptor-ligand interactions. We identified a direct interaction between HIV-1 envelope and a cellular rece...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(02)00084-1

    authors： Wahren B,Ljungberg K,Rollman E,Levi M,Zuber B,Kjerrström Zuber A,Hinkula J,Leandersson AC,Calarota S,Hejdeman B,Bratt G,Sandström E

    更新日期：2002-05-06 00:00:00

  • Biodistribution and lymph node retention of polysaccharide-based immunostimulating nanocapsules.

    abstract：:The adjuvant properties of polyglucosamine/squalene-based nanocapsules (PG-nanocapsules) associated with different subunit antigens has been previously reported. Thus, the aim of the present study was to monitor the biodistribution of PG-nanocapsules and their affinity for the draining lymph nodes after subcutaneous (...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.01.059

    authors： Vicente S,Goins BA,Sanchez A,Alonso MJ,Phillips WT

    更新日期：2014-03-26 00:00:00

  • Epitope-based sieve analysis of Plasmodium falciparum sequences from a FMP2.1/AS02A vaccine trial is consistent with differential vaccine efficacy against immunologically relevant AMA1 variants.

    abstract：:To prevent premature dismissal of promising vaccine programs, it is critical to determine if lack of efficacy in the field is due to allele specific-efficacy, rather than to the lack of immunogenicity of the candidate antigen. Here we use samples collected during a field trial of the AMA1-based FMP2.1/AS02A malaria va...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.06.035

    authors： Ouattara A,Niangaly A,Adams M,Coulibaly D,Kone AK,Traore K,Laurens MB,Tolo Y,Kouriba B,Diallo DA,Doumbo OK,Plowe CV,Djimdé A,Thera MA,Laufer MK,Takala-Harrison S,Silva JC

    更新日期：2020-07-31 00:00:00

  • Immunogenicity, safety and tolerability of MF59-adjuvanted seasonal influenza vaccine in children with juvenile idiopathic arthritis.

    abstract：:In order to evaluate the immunogenicity, safety, and tolerability of the MF-59 adjuvanted seasonal influenza vaccine in children and adolescents with juvenile idiopathic arthritis (JIA) treated with different anti-rheumatic drugs, 60 pediatric patients with JIA (30 treated with disease-modifying anti-rheumatic drugs [...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.11.083

    authors： Dell'Era L,Corona F,Daleno C,Scala A,Principi N,Esposito S

    更新日期：2012-01-20 00:00:00

  • Prevention of Coxiella burnetii shedding in infected dairy herds using a phase I C. burnetii inactivated vaccine.

    abstract：:The main objective of this study was to assess the efficacy of a monovalent inactivated vaccine containing phase I Coxiella burnetii to prevent Coxiella shedding in susceptible dairy cows within infected herds in comparison to a placebo. A total of 336 dairy cows and heifers, from six spontaneously infected herds, wer...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.vaccine.2008.06.023

    authors： Guatteo R,Seegers H,Joly A,Beaudeau F

    更新日期：2008-08-12 00:00:00

  • Tetravalent dengue DIIIC protein together with alum and ODN elicits a Th1 response and neutralizing antibodies in mice.

    abstract：:Dengue disease is a global challenge for healthcare systems particularly during outbreaks, and millions of dollars are spent every year for vector control. An efficient and safe vaccine that is cost-effective could resolve the burden that dengue virus imposes on affected countries. We describe here the immunogenicity ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.01.074

    authors： Zuest R,Valdes I,Skibinski D,Lin Y,Toh YX,Chan K,Hermida L,Connolly J,Guillen G,Fink K

    更新日期：2015-03-17 00:00:00

  • Indicators to assess National Immunization Technical Advisory Groups (NITAGs).

    abstract：:A National Immunization Technical Advisory Group (NITAG) is an expert advisory committee that provides evidence-based recommendations to the Ministry of Health (MoH) to guide immunization programs and policies. The World Health Organization (WHO), the Initiative for Supporting National Independent Immunization and Vac...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.01.047

    authors： Blau J,Sadr-Azodi N,Clementz M,Abeysinghe N,Cakmak N,Duclos P,Janusz C,Jauregui B,Mihigo R,Mosina L,Takashima Y,Senouci K

    更新日期：2013-05-28 00:00:00

  • An E2 sub-unit marker vaccine does not prevent horizontal or vertical transmission of classical swine fever virus.

    abstract：:An experimental infection with classical swine fever (CSF) virus in E2 sub-unit marker vaccine vaccinated gilts was conducted in order to evaluate the effect of vaccination on virus transmission and course of the disease. Therefore, clinical signs as well as horizontal and vertical virus transmission were monitored in...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(01)00320-6

    authors： Dewulf J,Laevens H,Koenen F,Mintiens K,de Kruif A

    更新日期：2001-10-12 00:00:00

  • Effect of passive antibody on the immune response of cotton rats to purified F and G glycoproteins of respiratory syncytial virus (RSV).

    abstract：:The effect of passively transferred RSV immune serum on the antibody response to a single dose of purified RSV fusion (F) and large (G) glycoproteins was studied in cotton rats. Passively transferred antibody that achieved serum antibody levels similar to those seen in newborn human infants resulted in a seven- to eig...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(91)90151-u

    authors： Murphy BR,Prince GA,Collins PL,Hildreth SW,Paradiso PR

    更新日期：1991-03-01 00:00:00

  • Measurement of Clostridium perfringens beta-toxin production by surface plasmon resonance immunoassay.

    abstract：:A rapid and sensitive assay using surface plasmon resonance (SPR) immunoassay has been developed for the detection of Clostridium perfringens beta-toxin. The SPR immunoassay was conducted off-line by passing fermentation broth by a sensor chip coated with a monoclonal antibody specific for C. perfringens beta-toxin. Q...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(97)00282-x

    authors： Hsieh HV,Stewart B,Hauer P,Haaland P,Campbell R

    更新日期：1998-05-01 00:00:00

  • Association of both consistency and strength of self-reported clinician recommendation for HPV vaccination and HPV vaccine uptake among 11- to 12-year-old children.

    abstract：PURPOSE:We tested the hypotheses that consistency and strength of clinician recommendation of the human papillomavirus (HPV) vaccination would be associated with vaccine delivery rates. METHODS:From October 2015 through January 2016, we conducted a survey of primary care clinicians (n=227) in Southeastern Minnesota to...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.09.056

    authors： Finney Rutten LJ,St Sauver JL,Beebe TJ,Wilson PM,Jacobson DJ,Fan C,Breitkopf CR,Vadaparampil ST,MacLaughlin KL,Jacobson RM

    更新日期：2017-10-27 00:00:00

  • Compatibility of a live infectious bovine rhinotraheitis (IBR) marker vaccine and an inactivated bovine viral diarrhoea virus (BVDV) vaccine.

    abstract：:The target animals and vaccination regimes for vaccines against the bovine rhinotracheitis (IBR) and the bovine viral diarrhoea virus (BVDV) are very similar. Therefore, we have compared different schedules for the combined use of a live IBR marker vaccine and an inactivated BVD vaccine. The neutralizing antibody resp...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.06.050

    authors： Alvarez M,Bielsa JM,Santos L,Makoschey B

    更新日期：2007-09-04 00:00:00

  • Correlates of immunity for pneumococcal conjugate vaccines.

    abstract：:The purpose of the NIAID/FDA joint workshop, "correlates of immunity for pneumococcal conjugate vaccines (PCVs)," was to discuss the present understanding of protective immunity against invasive pneumococcal disease and identify in vitro measures that may represent immunologic correlates in future clinical trials. Ani...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(03)00025-2

    authors： Lee LH,Frasch CE,Falk LA,Klein DL,Deal CD

    更新日期：2003-05-16 00:00:00

  • Feasibility of a pilot intervention to reduce pain and syncope during adolescent vaccination.

    abstract：PURPOSE:Vaccines recommended for adolescents are considered safe and effective, however administration may occasionally result in acute pain at the injection site or syncope (fainting). These adverse effects pose a risk to patient safety and are potential barriers to adherence to future vaccinations. We assessed a nove...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.05.070

    authors： Henninger ML,Kuntz JL,Firemark AJ,Varga AM,Bok K,Naleway AL

    更新日期：2018-06-22 00:00:00