当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Immunogenicity of a fusion protein linking the beta subunit carboxyl terminal peptide (CTP) of human chorionic gonadotropin to the B subunit of Escherichia coli heat-labile enterotoxin (LTB).

Immunogenicity of a fusion protein linking the beta subunit carboxyl terminal peptide (CTP) of human chorionic gonadotropin to the B subunit of Escherichia coli heat-labile enterotoxin (LTB).

Abstract：

:Human chorionic gonadotropin (hCG) is currently under investigation as an antigenic target in both anti-cancer and anti-fertility vaccines. Formulations studied to date show promise in clinical trials for both applications yet are expensive to produce and require frequented administration in order to maintain an effective antibody titer. We have engineered a fusion protein consisting of Escherichia coli heat-labile enterotoxin subunit B (LTB) genetically linked at its C terminus via a nine amino acid linker to the 37 amino acid carboxyl terminal peptide (CTP) of the hCG beta chain. This LTB-CTP fusion protein is stably expressed in bacteria and forms pentamers of full-length protein subunits. Purified LTB-CTP protein hCG-specific antibodies in mice without additional adjuvants.

journal_name

Vaccine

journal_title

Vaccine

authors

Rock EP,Reich KA,Lyu DM,Hovi M,Hardy J,Schoolnik GK,Stocker BA,Stevens V

doi

10.1016/s0264-410x(96)00046-1

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

1560-8

issue

16

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(96)00046-1

journal_volume

14

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Financing children's vaccines.

    abstract：:A 2006 Commonwealth Association of Paediatric Gastroenterology and Nutrition workshop on financing children's vaccines highlighted the potential for vaccines to control diarrhoea and other diseases as well as spur economic development through better health. Clear communication of vaccination value to decision-makers i...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.08.072

    authors： Nelson EA,Sack D,Wolfson L,Walker DG,Seng LF,Steele D

    更新日期：2009-11-20 00:00:00

  • An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine.

    abstract：:To test whether inactivated influenza vaccines distributed during the 2003-2004 influenza season in the northern hemisphere were able to confer protection against the mismatched variant A/Fujian/411/2002 virus strain, we measured haemagglutination inhibiting (HI) antibodies in elderly subjects vaccinated with three in...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.01.015

    authors： Del Giudice G,Hilbert AK,Bugarini R,Minutello A,Popova O,Toneatto D,Schoendorf I,Borkowski A,Rappuoli R,Podda A

    更新日期：2006-04-12 00:00:00

  • Measurement of antibody responses to Modified Vaccinia virus Ankara (MVA) and Dryvax(®) using proteome microarrays and development of recombinant protein ELISAs.

    abstract：:Modified Vaccinia virus Ankara (MVA) is an attenuated strain of vaccinia virus that is being considered as a safer alternative to replicating vaccinia vaccine strains such as Dryvax(®) and ACAM2000. Its excellent safety profile and large genome also make it an attractive vector for the delivery of heterologous genes f...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.11.021

    authors： Hermanson G,Chun S,Felgner J,Tan X,Pablo J,Nakajima-Sasaki R,Molina DM,Felgner PL,Liang X,Davies DH

    更新日期：2012-01-11 00:00:00

  • Effective adjuvants for the induction of antigen-specific delayed-type hypersensitivity.

    abstract：:Vaccines utilizing poorly immunogenic subunit antigens are dependent upon adjuvants to drive the appropriate T cell responses. In an effort to determine the ability of several adjuvants to promote cell-mediated immunity (CMI), we assessed delayed-type hypersensitivity (DTH) in mice inoculated with heat-killed Listeria...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(96)00199-5

    authors： Baldridge JR,Ward JR

    更新日期：1997-03-01 00:00:00

  • Interventions to reduce the burden of vaccine-preventable diseases among migrants and refugees worldwide: A scoping review of published literature, 2006-2018.

    abstract：BACKGROUND:Disparities in vaccine-preventable disease (VPD) burden and immunisation coverage between migrants and refugees and their host populations have been described in numerous countries worldwide. Effective strategies are required to reduce the health disparities and immunisation inequities experienced by migrant...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2020.09.054

    authors： Charania NA,Gaze N,Kung JY,Brooks S

    更新日期：2020-10-27 00:00:00

  • In vivo CTL induction with point-substituted ovalbumin peptides: immunogenicity correlates with peptide-induced MHC class I stability.

    abstract：:Class I molecules are conformationally sensitive to peptide binding, prolonging the complex's half-life on the surface of the cell. By making a series of H2-Kb anchor motif amino acid point substitutions in the ovalbumin 257-264 octamer, we were able to analyse subtle changes in peptide binding, Kb stabilization and i...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(95)93320-9

    authors： Lipford GB,Bauer S,Wagner H,Heeg K

    更新日期：1995-02-01 00:00:00

  • Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice.

    abstract：:Safety of individuals at risk of immune suppression is an important concern for live vaccines. The new-generation tuberculosis vaccine candidate MTBVAC, a genetically engineered doubly attenuated Mycobacterium tuberculosis mutant with deletions in phoP and fadD26 virulence genes has demonstrated comparable safety in d...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.07.047

    authors： Solans L,Uranga S,Aguilo N,Arnal C,Gomez AB,Monzon M,Badiola JJ,Gicquel B,Martin C

    更新日期：2014-09-08 00:00:00

  • Measles vaccination in Africa: by how much could routine coverage be improved?

    abstract：:Assuming that the level of Bacille Calmette Guerin (BCG) coverage gives a measure of access to immunisation services, it is possible to derive what fraction of infants are not immunised against measles due to under-utilisation of existing services (rather than unavailability of services). According to the most recent ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(01)00264-x

    authors： Edmunds WJ,Gay NJ,Henao Restrepo AM,Olivé JM,Bele O

    更新日期：2001-10-12 00:00:00

  • New vaccine introductions in Africa before and during the decade of vaccines - Are we making progress?

    abstract：:Vaccines are excellent investments with far-reaching rewards beyond individual and population health, but their introduction into national programs has been historically slow in Africa. We provide an overview of the introduction of new and underutilized vaccines in countries of the WHO African Region by 2017, using da...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.05.002

    authors： Sambala EZ,Wiyeh AB,Ngcobo N,Machingaidze S,Wiysonge CS

    更新日期：2019-05-31 00:00:00

  • Effectiveness of childhood vaccination against rotavirus in sub-Saharan Africa: the case of Nigeria.

    abstract：:Rotavirus diarrhoea is associated with high childhood mortality in developing countries. A new vaccine was recently licensed in Mexico. The objective of this study was to assess the effectiveness of routine childhood vaccination by this new vaccine in a developing country. We constructed a decision tree to compare two...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.07.038

    authors： Melliez H,Boelle PY,Baron S,Mouton Y,Yazdanpanah Y

    更新日期：2007-01-04 00:00:00

  • Internationally adopted children: what vaccines should they receive?

    abstract：:It is of paramount importance to know the vaccination status in internationally adopted children, so that they can be correctly immunized. This study ascertains the seroprotection rate for vaccine-preventable diseases and the validity of the immunization cards in 637 adopted children. The absence of the immunization c...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.08.029

    authors： Cilleruelo MJ,de Ory F,Ruiz-Contreras J,González-González R,Mellado MJ,García-Hortelano M,Villota J,García-Ascaso M,Piñeiro R,Martín-Fontelos P,Herruzo R

    更新日期：2008-10-29 00:00:00

  • Economic analysis for evidence-based policy-making on a national immunization program: a case of rotavirus vaccine in Thailand.

    abstract：:Severe diarrhea caused by rotavirus is a health problem worldwide, including Thailand. The World Health Organization has recommended incorporating rotavirus vaccination into national immunization programs. This policy has been implemented in several countries, but not in Thailand where the mortality rate is not high. ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.02.047

    authors： Muangchana C,Riewpaiboon A,Jiamsiri S,Thamapornpilas P,Warinsatian P

    更新日期：2012-04-16 00:00:00

  • Structural analysis and immunogenicity of recombinant major envelope protein (rA27L) of buffalopox virus, a zoonotic Indian vaccinia-like virus.

    abstract：:Buffalopox virus (BPXV), an Indian variant of vaccinia virus (VACV), is a zoonotic agent and affects buffaloes, cattle and humans. A27L is one of the conserved major immuno-dominant envelope proteins of orthopox viruses (OPVs) involved in viral entry/maturation and elicits neutralizing antibodies. In this study, the A...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.08.058

    authors： Kumar A,Yogisharadhya R,Bhanuprakash V,Venkatesan G,Shivachandra SB

    更新日期：2015-10-05 00:00:00

  • Schistosoma japonicum calcium-binding tegumental protein SjTP22.4 immunization confers praziquantel schistosomulumicide and antifecundity effect in mice.

    abstract：:A family of platyhelminth tegument-specific proteins comprising of one or two calcium ion binding EF-hand and a dynein light chain-like domain, termed tegumental proteins, are considered as candidates of vaccine. In this study, we cloned and characterized SjTP22.4, a novel membrane-anchored tegumental protein in Schis...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.05.056

    authors： Zhang Z,Xu H,Gan W,Zeng S,Hu X

    更新日期：2012-07-20 00:00:00

  • Definition of MHC-restricted CTL epitopes from non-variable number of tandem repeat sequence of MUC1.

    abstract：:Mucin1 (MUC1) is expressed ubiquitously on breast cancer cells and is a potential target for the generation of cytotoxic T cells for vaccination against breast cancer. Thus far studies of the immunogenicity of MUC1 have used peptides from the variable number of tandem repeat (VNTR); mice so immunised can generate stro...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00515-0

    authors： Pietersz GA,Li W,Osinski C,Apostolopoulos V,McKenzie IF

    更新日期：2000-04-03 00:00:00

  • Cost-effectiveness of three different vaccination strategies against measles in Zambian children.

    abstract：:The vaccination program in Zambia includes one dose of measles vaccine at 9 months of age. The objective of this study was to compare the cost-effectiveness of the current one-dose measles vaccination program with an immunization schedule in which a second dose is provided either through routine health services or thr...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.07.007

    authors： Dayan GH,Cairns L,Sangrujee N,Mtonga A,Nguyen V,Strebel P

    更新日期：2004-01-02 00:00:00

  • Determinants of susceptibility to challenge and the antibody response of adult volunteers given experimental respiratory syncytial virus vaccines.

    abstract：:The virulence and immunogenicity of a wild-type respiratory syncytial (RS) virus together with four temperature sensitive (ts) mutants derived from this isolate were tested by intranasal inoculation into adult volunteers. Resistance to challenge correlated with neutralizing antibody titres in nasal secretions and to a...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/0264-410x(90)90051-m

    authors： Watt PJ,Robinson BS,Pringle CR,Tyrrell DA

    更新日期：1990-06-01 00:00:00

  • Pandemic whole-virion, Vero-cell-derived, adjuvant-free influenza A H1N1 vaccine in patients with solid tumors and hematologic malignancies receiving concurrent anticancer treatment: Immunogenicity, tolerability, and acceptability during the pandemic situ

    abstract：:Patients with malignancies are considered to be at increased risk of acquiring influenza. Because of higher complication and case fatality rates, preventive measures such as vaccination are of great interest. The objective of this study was to assess the acceptability, tolerability and immunogenicity of an adjuvant-fr...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.09.005

    authors： Lagler H,Tobudic S,Ramharter M,Elandt K,Sperr WR,Redlberger-Fritz M,Popow-Kraupp T,Jäger U,Zielinski CC,Burgmann H

    更新日期：2012-11-06 00:00:00

  • Inclusion of the value of herd immunity in economic evaluations of vaccines. A systematic review of methods used.

    abstract：OBJECTIVE:The objectives of this review were to identify vaccine economic evaluations that include herd immunity and describe the methodological approaches used. METHODS:We used Kim and Goldie's search strategy from a systematic review (1976-2007) of modelling approaches used in vaccine economic evaluations and additi...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2017.10.024

    authors： Nymark LS,Sharma T,Miller A,Enemark U,Griffiths UK

    更新日期：2017-12-14 00:00:00

  • Experimental infection by Chlamydia pneumoniae in the hamster.

    abstract：:We report that intraperitoneal injection of Chlamydia pneumoniae purified elementary bodies (EBs) in the hamster causes a systemic infection allowing the isolation of viable chlamydiae from several organs for several days post-infection (p.i.). In particular, spleen infection occurred up to Day 7 p.i. in 100% of anima...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.09.035

    authors： Sambri V,Donati M,Storni E,Di Leo K,Agnusdei M,Petracca R,Finco O,Grandi G,Ratti G,Cevenini R

    更新日期：2004-03-12 00:00:00

  • Characterization of a multi-lipopeptides mixture used as an HIV-1 vaccine candidate.

    abstract：:A multi-component vaccine has been defined, which contains six different synthetic 24- to 32-amino acid lipopeptides derived from the sequence of HIV-1 proteins. The physicochemical properties of the lipopeptide components were compatible with multi-dimensional analysis, using RP-HPLC, Edman sequencing, electrospray m...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00196-6

    authors： Klinguer C,David D,Kouach M,Wieruszeski JM,Tartar A,Marzin D,Levy JP,Gras-Masse H

    更新日期：1999-09-01 00:00:00

  • Pediatric hospitalizations attributable to rotavirus gastroenteritis among Cambodian children: Seven years of active surveillance, 2010-2016.

    abstract：BACKGROUND:Each year, approximately 1,066 Cambodian children under five years old die of diarrhea, and 51% of these deaths are due to rotavirus gastroenteritis. Quantifying childhood hospitalizations caused by severe rotavirus infections is also important in demonstrating disease burden caused by this virus. The object...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.03.032

    authors： Angkeabos N,Rin E,Vichit O,Chea C,Tech N,Payne DC,Fox K,Heffelfinger JD,Grabovac V,Nyambat B,Diorditsa S,Samnang C,Hossain MS

    更新日期：2018-12-14 00:00:00

  • Evaluation of the safety, reactogenicity and immunogenicity of FluBlok® trivalent recombinant baculovirus-expressed hemagglutinin influenza vaccine administered intramuscularly to healthy adults 50-64 years of age.

    abstract：BACKGROUND:Alternative methods for influenza vaccine production are needed to ensure adequate supplies. METHODS:Healthy adults 50-64 years were assigned randomly to receive one intramuscular injection of trivalent recombinant hemagglutinin (rHA) or U.S. licensed trivalent inactivated vaccine (TIV) containing H1, H3 an...

    journal_title：Vaccine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.vaccine.2011.01.039

    authors： Baxter R,Patriarca PA,Ensor K,Izikson R,Goldenthal KL,Cox MM

    更新日期：2011-03-09 00:00:00

  • Vaccination for control of Salmonella in poultry.

    abstract：:Salmonella spp. are facultative intracellular pathogens causing localised or systemic infections, in addition to a chronic asymptomatic carrier state. They are of worldwide economic and public health significance. In poultry, which represent important sources of cheap protein throughout the world, fowl typhoid and pul...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(99)00060-2

    authors： Zhang-Barber L,Turner AK,Barrow PA

    更新日期：1999-06-04 00:00:00

  • Algammulin, a new vaccine adjuvant comprising gamma inulin particles containing alum: preparation and in vitro properties.

    abstract：:Crystallization of inulin with alum forms a fine (1-2 micron) suspension of electron-dense ovoids; the alum is embedded in inulin particles, which are then converted to the immune stimulant polymorphic form, gamma inulin. This very stable hybrid preparation is termed Algammulin. Preferred conditions for its preparatio...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(91)90063-c

    authors： Cooper PD,Steele EJ

    更新日期：1991-05-01 00:00:00

  • Immunization of livestock with DNA vaccines: current studies and future prospects.

    abstract：:Early studies using DNA immunization suggest the potential benefits of this form of immunization including: long-lived immunity, a broad spectrum of immune responses (both cell-mediated immunity and humoral responses) and the simultaneous induction of immunity to a variety of pathogens through the use of multivalent v...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00476-x

    authors： van Drunen Littel-van den Hurk S,Loehr BI,Babiuk LA

    更新日期：2001-03-21 00:00:00

  • Levels of antibodies specific to diphtheria toxoid, tetanus toxoid, and Haemophilus influenzae type b in healthy children born to Tdap-vaccinated mothers.

    abstract：INTRODUCTION:Vaccination of pregnant women protects both women and their newborns against some infectious diseases. Thailand implemented tetanus toxoid (TT) vaccination of pregnant women in 1977, which was replaced by tetanus-diphtheria toxoid (dT) vaccination in 2005. The tetanus-diphtheria-acellular pertussis (Tdap) ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.08.058

    authors： Wanlapakorn N,Maertens K,Thongmee T,Srimuan D,Thatsanathorn T,Van Damme P,Leuridan E,Poovorawan Y

    更新日期：2020-10-14 00:00:00

  • Developing an HPV vaccine to prevent cervical cancer and genital warts.

    abstract：:The challenges of the journey from target identification through development of a prophylactic quadrivalent human papillomavirus (HPV) vaccine have been met in Gardasil. Cervical cancer is the second leading cause of cancer-related death in women worldwide. Approximately 70% of cervical cancer is caused by infection w...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2007.01.013

    authors： Bryan JT

    更新日期：2007-04-20 00:00:00

  • Priming of measles virus-specific humoral- and cellular-immune responses in macaques by DNA vaccination.

    abstract：:Although the currently used live attenuated measles vaccines are safe and effective, they are dependent on cold chain maintenance and are often ineffective in young infants due to interference by maternal antibody. Therefore, besides vector-based vaccines, different new generation non-replicating candidate measles vac...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00048-8

    authors： Stittelaar KJ,de Swart RL,Vos HW,van Amerongen G,Sixt N,Wild TF,Osterhaus AD

    更新日期：2002-05-15 00:00:00

  • An assessment of shedding with the oral rabies virus vaccine strain SPBN GASGAS in target and non-target species.

    abstract：:A safety requirement for live vaccines is investigating possible shedding in recipients since the presence of replication competent vaccine in secretions could result in direct and indirect horizontal transmission. This is especially relevant for oral rabies vaccine baits that are deliberately distributed into the env...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.12.076

    authors： Vos A,Freuling C,Ortmann S,Kretzschmar A,Mayer D,Schliephake A,Müller T

    更新日期：2018-02-01 00:00:00