Algammulin, a new vaccine adjuvant comprising gamma inulin particles containing alum: preparation and in vitro properties.

abstract：:Alternative DNA vaccine constructs such as fully synthetic linear expressing cassettes (LECs) offer the advantage of accelerated manufacturing techniques as well as the lack of both antibiotic resistance genes and bacterial contaminants. The speed of manufacture makes LEC technology a possible future vaccination strat...

journal_title：Vaccine

authors： Shen X,Söderholm J,Lin F,Kobinger G,Bello A,Gregg DA,Broderick KE,Sardesai NY

更新日期：2012-11-06 00:00:00

abstract：:Gamma inulin and Algammulin, two new adjuvants, were examined and compared with alum and Freund's Complete/Incomplete Adjuvant (FCA/FIA), for potentiation of cell-mediated immunity (CMI) and humoral immunity in sheep to a recombinant Taenia ovis antigen. The ability to protect sheep when challenged with live T. ovis e...

journal_title：Vaccine

authors： Deol HS,Palmer DG,Dunsmore T,Carnegie PR

更新日期：1995-04-01 00:00:00

abstract：:Live cold-adapted recombinant bivalent vaccine of influenza type A was studied in a controlled field trial in 1982-1983 among nearly 30,000 children 3-15 years old. The bivalent vaccine consisted of recombinants 47/25/1 (H1N1) and 47/7/2 (H3N2) of wild-type viruses A/Brazil/11/78 (H1N1) and A/Bangkok/1/79 (H3N2) with ...

journal_title：Vaccine

authors： Alexandrova GI,Budilovsky GN,Koval TA,Polezhaev FI,Garmashova LM,Ghendon YuZ,Romanova YR,Smorodintsev AA

更新日期：1986-06-01 00:00:00

abstract：:Dengue is a major infectious disease that affects people living in tropical and subtropical regions around the world. The causative agents are dengue virus serotype 1, 2, 3, and 4 (DENV1, 2, 3, and 4). Developing a vaccine for dengue is a high priority for public health, but traditional methods have faced numerous obs...

journal_title：Vaccine

authors： Pang X,Guo Y,Zhou Y,Fu W,Gu X

更新日期：2014-06-24 00:00:00

abstract：:The aim of the present study was to investigate the immune response to native outer membrane vesicles (NOMVs) of Neisseria lactamica with and without Bordetella pertussis (BP) as adjuvant in intranasal (i.n./i.m) immunization. N. lactamica NOMVs delivered intranasally (i.n) to BALB/c mice in a final volume of 5microl ...

journal_title：Vaccine

authors： Ito AY,Néri S,Machado MS,Tunes CF,De Gaspari EN

更新日期：2009-05-26 00:00:00

abstract：:Yellow fever vaccine (YFV) is recommended in endemic areas but represents a risk for egg-allergic patients, as it is cultivated in embryonated eggs. This study aims to describe the outcomes of yellow fever vaccination in patients with confirmed egg allergy (EA). Methods:A prospective study was conducted from January 2...

journal_title：Vaccine

authors： Gerhardt CMB,Castro APBM,Pastorino AC,Dorna MB,Nunes-Santos CJ,Aquilante BP,Miyaji KT,Lopes MH

更新日期：2020-09-29 00:00:00

abstract：:An attenuated chikungunya (CHIK) virus clone was developed for production of a live vaccine for human use. CHIK strain 15561 was subjected to 18 plaque-to-plaque passages in MRC-5 cultures before CHIK 181/clone 25 was selected as vaccine seed based on homogeneous small plaque size, suckling mouse avirulence, reduced m...

journal_title：Vaccine

authors： Levitt NH,Ramsburg HH,Hasty SE,Repik PM,Cole FE Jr,Lupton HW

更新日期：1986-09-01 00:00:00

abstract：:An Madin-Darby canine kidney (MDCK) cell line, 9B9-1E4, was cloned by limit dilution from a heterologous cell population and chosen as a potential production cell substrate for cell culture-based influenza vaccine manufacture. Since MDCK cells are transformed cells of canine origin, extensive characterization, includi...

journal_title：Vaccine

authors： Liu J,Mani S,Schwartz R,Richman L,Tabor DE

更新日期：2010-02-03 00:00:00

abstract：:The immunogenicity and safety of an HPV-16/18 AS04-adjuvanted vaccine were assessed in women aged 26-55 years and compared with women aged 15-25 years in a Phase III, non-randomised, open-label, age-stratified study. Overall the vaccine was well tolerated and 100% seropositivity was achieved 1 month after the third do...

journal_title：Vaccine

authors： Schwarz TF,Spaczynski M,Schneider A,Wysocki J,Galaj A,Perona P,Poncelet S,Zahaf T,Hardt K,Descamps D,Dubin G,HPV Study Group for Adult Women.

更新日期：2009-01-22 00:00:00

abstract：INTRODUCTION:Online media may influence women's decision to undergo vaccination during pregnancy. The aims of this mixed-methods study were to: (1) examine the portrayal of maternal vaccination in online media and (2) establish the perceived target of vaccine protection as viewed by pregnant women and maternity healthc...

journal_title：Vaccine

authors： Wilcox CR,Bottrell K,Paterson P,Schulz WS,Vandrevala T,Larson HJ,Jones CE

更新日期：2018-11-29 00:00:00

abstract：:Development of active targeted immunotherapeutics is a rapid developing field in the arena of chronic infectious diseases. The question of repeated, closely spaced administration of immunotherapeutics to achieve a rapid impact on the replicating agent is an important one. We analyzed here, using a prototype adenovirus...

journal_title：Vaccine

authors： Boukhebza H,Dubois C,Koerper V,Evlachev A,Schlesinger Y,Menguy T,Silvestre N,Riedl P,Inchauspé G,Martin P

更新日期：2014-05-30 00:00:00

abstract：:CRM(197) is a carrier protein in certain conjugate vaccines. When multiple conjugate vaccines with the same carrier protein are administered simultaneously, reduced response to vaccines and/or antigens related to the carrier protein may occur. This study examined responses of infants who, in addition to diphtheria tox...

journal_title：Vaccine

authors： Usonis V,Bakasenas V,Lockhart S,Baker S,Gruber W,Laudat F

更新日期：2008-08-18 00:00:00

abstract：:Bovine mastitis is responsible of major economic losses on dairy farms worldwide. In Argentine dairy herds, Staphylococcus aureus is the main causative agent of the disease. The ineffectiveness of some current practices to control S. aureus infections, often leads to a chronic and recurrent infection with persistent b...

journal_title：Vaccine

authors： Pellegrino M,Giraudo J,Raspanti C,Odierno L,Bogni C

更新日期：2010-06-17 00:00:00

abstract：:In order to evaluate the long-term immunity 2 and 3 years after booster vaccination against tick-borne encephalitis (TBE) following time intervals 3 years and longer since last TBE immunization, 195 (mean age 50.5+/-15.1 years) and 240 subjects (mean age 47.0+/-15.4 years), respectively, who had received a single boos...

journal_title：Vaccine

authors： Rendi-Wagner P,Paulke-Korinek M,Kundi M,Wiedermann U,Laaber B,Kollaritsch H

更新日期：2007-06-28 00:00:00

abstract：:In order to meet the global demand for rapid production of pandemic influenza vaccines, we have developed a recombinant fusion vaccine platform in which the globular head of hemagglutinin (HA) antigen is genetically fused to bacterial flagellin (a TLR5 ligand). These flagellin-HA fusion vaccine candidates elicit highl...

journal_title：Vaccine

authors： Liu G,Song L,Reiserova L,Trivedi U,Li H,Liu X,Noah D,Hou F,Weaver B,Tussey L

更新日期：2012-11-06 00:00:00

abstract：:Although vaccination against Streptococcus pneumoniae (S. pneumoniae) and Haemophilus influenzae type b (Hib) is recommended for immunocompromised patients, such as patients with B-cell chronic lymphocytic leukaemia (B-CLL), its protective effect is questionable. We studied antibody responses to pneumococcal polysacch...

journal_title：Vaccine

authors： Hartkamp A,Mulder AH,Rijkers GT,van Velzen-Blad H,Biesma DH

更新日期：2001-02-08 00:00:00

abstract：BACKGROUND:The relative importance of different attitudes in predicting vaccination among healthcare personnel (HCP) is unclear. We hypothesized that HCP who feel at risk without vaccination or say they would regret not getting vaccinated would be more likely to get vaccinated than HCP who do not expect these emotional...

journal_title：Vaccine

authors： Thompson MG,Gaglani MJ,Naleway A,Ball S,Henkle EM,Sokolow LZ,Brennan B,Zhou H,Foster L,Black C,Kennedy ED,Bozeman S,Grohskopf LA,Shay DK

更新日期：2012-05-21 00:00:00

abstract：:The relevance of CD4+T-cells, viral load and age in the immunological response to influenza infection and vaccination in HIV-1 infected individuals has previously been pointed out. Our study aimed at assessing, in the setting of 2009 A(H1N1)pdm09 influenza vaccination, whether quantification of activation-induced deam...

journal_title：Vaccine

authors： Cagigi A,Pensieroso S,Ruffin N,Sammicheli S,Thorstensson R,Pan-Hammarström Q,Hejdeman B,Nilsson A,Chiodi F

更新日期：2013-04-26 00:00:00

abstract：:Intranasal (i.n.) immunization is an effective regimen for the prophylaxis of respiratory diseases in early life. The aim of this study was to assess the need for nasal-associated lymphoid tissue (NALT) and cervical lymph nodes (CLN) in induction of protective immunity following mucosal vaccination of infant mice. We ...

journal_title：Vaccine

authors： Sabirov A,Metzger DW

更新日期：2008-03-17 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) often fail to produce protective antibodies to hepatitis B virus (HBV) surface antigen after vaccination. Diabetes mellitus (DM) is the most common cause of CKD; however it is not clear whether it affects immunological response to HBV vaccine in these patients. AIM...

journal_title：Vaccine

authors： Alavian SM,Tabatabaei SV

更新日期：2010-05-14 00:00:00

abstract：INTRODUCTION:Information on the costs of routine immunization programs is needed for budgeting, planning, and domestic resource mobilization. This information is particularly important for countries such as Tanzania that are preparing to transition out of support from Gavi, the Vaccine Alliance. This study aimed to est...

journal_title：Vaccine

authors： Vaughan K,Clarke-Deelder E,Tani K,Lyimo D,Mphuru A,Manzi F,Schütte C,Ozaltin A

更新日期：2020-11-10 00:00:00

abstract：:A conjugate vaccine against meningococcus A and C was prepared using the non-toxic mutant of diphtheria toxin CRM 197 as a carrier protein. Capsular polysaccharides of Neisseria meningitidis group A and C were hydrolysed and the resulting oligosaccharides were then coupled to CRM 197 in order to obtain conjugates with...

journal_title：Vaccine

authors： Costantino P,Viti S,Podda A,Velmonte MA,Nencioni L,Rappuoli R

更新日期：1992-01-01 00:00:00

abstract：:This study sought to explore how parents respond to competing media messages about vaccine safety. Six focus groups with mothers of infants were shown television vignettes of typical pro- and anti-vaccination claims. Thematic analysis of transcripts was undertaken. Mothers expressed surprise and concern about alleged ...

journal_title：Vaccine

authors： Leask J,Chapman S,Hawe P,Burgess M

更新日期：2006-11-30 00:00:00

abstract：BACKGROUND:The primary prevention measure for influenza infection has been the use of influenza vaccines. However, even when the vaccine and circulating strains are well-matched, some healthy children do not respond to the vaccine, likely due to a genetic basis for immune hyporesponsiveness. The primary objective of th...

journal_title：Vaccine

authors： Narwaney KJ,Glanz JM,Norris JM,Fingerlin TE,Hokanson JE,Rewers M,Hambidge SJ

更新日期：2013-02-04 00:00:00

abstract：:Since 1998, there have been multiple separate outbreaks of Bluetongue disease (BT) in Europe with the largest outbreak ever recorded in Northern Europe caused by Bluetongue virus serotype 8 (BTV-8). Coinciding with the BTV-8 outbreak, a virulent strain of BTV-1 emerged and co-infections of these two serotypes were rep...

journal_title：Vaccine

authors： Stewart M,Dubois E,Sailleau C,Bréard E,Viarouge C,Desprat A,Thiéry R,Zientara S,Roy P

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:Each year a substantial number of Dutch elderly suffers from herpes zoster (HZ), caused by the reactivation of the varicella zoster virus (VZV). A potential complication of HZ is postherpetic neuralgia (PHN) which results in a prolonged loss of quality of life. A large randomized clinical trial, labelled the...

journal_title：Vaccine

authors： de Boer PT,Pouwels KB,Cox JM,Hak E,Wilschut JC,Postma MJ

更新日期：2013-02-18 00:00:00

abstract：:Human pythiosis is an emerging disease in the tropical, subtropical and temperate regions of the world. It is caused by the straminipilan, fungus-like, aquatic organism Pythium insidiosum. Pythiosis occurs in localized as well as systemic or vascular forms. Most patients with arterial pythiosis usually have underlying...

journal_title：Vaccine

authors： Wanachiwanawin W,Mendoza L,Visuthisakchai S,Mutsikapan P,Sathapatayavongs B,Chaiprasert A,Suwanagool P,Manuskiatti W,Ruangsetakit C,Ajello L

更新日期：2004-09-09 00:00:00

abstract：BACKGROUND:As with many high-income countries, vaccination coverage against human papilloma virus (HPV) infection is not high in New Zealand (NZ) at 47% in school-aged girls for three doses. We estimate the health gains, net-cost and cost-effectiveness of the currently implemented HPV national vaccination programme of ...

journal_title：Vaccine

authors： Blakely T,Kvizhinadze G,Karvonen T,Pearson AL,Smith M,Wilson N

更新日期：2014-05-07 00:00:00

abstract：:Enterovirus type 71 (EV71) and coxsackievirus A 16 (CA16) are recognized as the major pathogens responsible for human hand-foot-mouth disease. To develop a bivalent EV71-CA16 vaccine, rhesus macaques immunized with two doses of this vaccine via the intradermal route were challenged with EV71 or CA16, and their clinica...

journal_title：Vaccine

authors： Fan S,Liao Y,Jiang G,Jiang L,Wang L,Xu X,Feng M,Yang E,Zhang Y,Cui W,Li Q

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:We aim to determine the vaccination coverage of social and healthcare workers in International sites of Samusocial, providing emergency care to homeless people, and to assess factors associated with having received necessary doses at adulthood. METHODS:Data on immunization coverage of social and healthcare ...

journal_title：Vaccine

authors： Marshall E,Salmon D,Bousfiha N,Togola Y,Ouedraogo F,Santantonio M,Dieng CK,Tartière S,Emmanuelli X

更新日期：2017-09-18 00:00:00