当前位置： SCI文献检索 > VACCINE期刊下所有文献 > An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine.

An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine.

Abstract：

:To test whether inactivated influenza vaccines distributed during the 2003-2004 influenza season in the northern hemisphere were able to confer protection against the mismatched variant A/Fujian/411/2002 virus strain, we measured haemagglutination inhibiting (HI) antibodies in elderly subjects vaccinated with three inactivated vaccines against the homologous A/H3N2 vaccine strain (A/Panama) and against the mismatched A/Fujian strain. The results showed that, while 76 to 80% of elder people vaccinated with conventional vaccines had protected levels of antibodies against the A/Fujian heterovariant strain, those vaccinated with the MF59-adjuvanted vaccine have protective levels of antibodies in >98% of the cases. We conclude that MF59-adjuvanted vaccines confer protection also against influenza virus strains which are not fully matched with those included in the vaccine.

journal_name

Vaccine

journal_title

Vaccine

authors

Del Giudice G,Hilbert AK,Bugarini R,Minutello A,Popova O,Toneatto D,Schoendorf I,Borkowski A,Rappuoli R,Podda A

doi

10.1016/j.vaccine.2006.01.015

subject

Has Abstract

pub_date

2006-04-12 00:00:00

pages

3063-5

issue

16

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)00027-2

journal_volume

24

pub_type

杂志文章

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