Abstract：
:Cationic antimicrobial peptides (CAMPs) are active defence components of the innate immune system. Several artificial CAMPs have been designed as antibiotic peptide therapeutics, but none have been reported to exert adjuvant activity in animal models. Here we show for the first time that an artificial CAMP, KLKLLLLLKLK (KLKL5KLK), is a potent inducer of adaptive immunity to co-injected antigens in vivo. High levels of antigen-specific antibodies were obtained after co-injection of KLKL5KLK with the model antigen ovalbumin (OVA) or a commercially available influenza vaccine. We show that KLKL5KLK induces a sustained immune response with a prevalent TH2 profile when co-injected with proteinaceous and peptide-based antigens. Furthermore, the immuno-enhancing activity of peptide KLKL5KLK was retained when C-terminally amidated or synthesised as retro-all-D-peptide. We provide evidence that KLKL5KLK enhances the association of antigen to antigen-presenting cells and forms a depot of antigen at the site of injection, making it an interesting adjuvant for novel vaccine design.
journal_name
Vaccinejournal_title
Vaccineauthors
Fritz JH,Brunner S,Birnstiel ML,Buschle M,Gabain Av,Mattner F,Zauner Wdoi
10.1016/j.vaccine.2004.03.007subject
Has Abstractpub_date
2004-09-03 00:00:00pages
3274-84issue
25-26eissn
0264-410Xissn
1873-2518pii
S0264410X0400218Xjournal_volume
22pub_type
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