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Early assessment of the efficacy of a human papillomavirus type 16 L1 virus-like particle vaccine.

Abstract：

:A post hoc analysis was performed using combined data from two Phase I tolerability/immunogenicity studies of monovalent human papillomavirus type 11 (HPV11) or HPV16 L1 virus-like particle (VLP) vaccines. The goal was to determine if the HPV16 L1 VLP vaccine protected against HPV16 infection. Vaccine or placebo was given at 0, 2 and 6 months. HPV16 infection was defined by positive polymerase chain reaction (PCR) results following vaccination. The incidence of HPV infection was observed to be 0 cases per 100 person-years at risk in the vaccine group, and 5 cases per 100 person-years at risk in the control group. These results support the institution of larger efficacy trials for HPV L1 VLP vaccines.

journal_name

Vaccine

journal_title

Vaccine

authors

Brown DR,Fife KH,Wheeler CM,Koutsky LA,Lupinacci LM,Railkar R,Suhr G,Barr E,Dicello A,Li W,Smith JF,Tadesse A,Jansen KU

doi

10.1016/j.vaccine.2003.11.059

subject

Has Abstract

pub_date

2004-07-29 00:00:00

pages

2936-42

issue

21-22

eissn

0264-410X

issn

1873-2518

pii

S0264410X04000222

journal_volume

22

pub_type

临床试验,杂志文章,随机对照试验

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