Abstract:
:How should public health authorities confront the threat of pandemic influenza? Is massive stockpiling the answer? If so, the costs could be overwhelming. Or is vaccination of pre-selected segments of the population the best approach? If so, then what about the tough ethical question that must be addressed: for whom--and by whose decision? Are local and national health authorities operating on the same wavelength? Just how all-encompassing should a national preparedness plan be? Finally, can we count on one national government to shuttle vaccines across Europe's internal borders where they are needed to deal with an outbreak--or will hoarding and panic ensue? These issues and more were the focus of debate during the conference's session on preparedness plans, chaired by Dr. D. Fedson, former professor of medicine at the University of Virginia. As participants observed, Europe faces an alarming diversity of approaches and states of readiness from one country to the next, which cries out for a coherent European policy.
journal_name
Vaccinejournal_title
Vaccineauthors
doi
10.1016/j.vaccine.2006.06.074subject
Has Abstractpub_date
2006-11-10 00:00:00pages
6766-9issue
44-46eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)00804-8journal_volume
24pub_type
杂志文章相关文献
VACCINE文献大全abstract::According to the multiple criteria used, the consensus sequences of HIV-1 gp120 and immunoglobulin heavy chain variable segment, which is more than 40 amino acids long, show structural similarities. We assume that this gp120 sequence might encode idiotopes. If this is the case then the particular idiotope-bearing gp12...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(95)98256-a
更新日期:1995-03-01 00:00:00
abstract::CD1d-binding glycolipids exert potent adjuvant effects on T-dependent Ab responses. The mechanisms include cognate interaction between CD1d-expressing B cells and TCR-expressing Type I CD1d-restricted natural killer T cells (NKTs). However, the critical NKT-derived factors that stimulate B cells are poorly understood....
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.09.060
更新日期:2011-11-15 00:00:00
abstract::The modular binding sites on the influenza A(H3N2) hemagglutinin protein are under significant pressure to acquire mutations in order to evade human antibody recognition. Analysis of these hemagglutinin epitopes in the strains circulating during 2017/18 and early 2018/19 identified the emergence of a new antigenic clu...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.03.068
更新日期:2019-05-27 00:00:00
abstract::Actinobacillus pleuropneumoniae is an important respiratory pathogen of swine, for which there is no highly effective vaccine. A phage expression library of the A. pleuropneumoniae genome was constructed and screened to identify potential vaccine components. Open reading frames within immuno-reactive phage were analyz...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.02.022
更新日期:2008-04-07 00:00:00
abstract:OBJECTIVE:To examine current vaccine sentiment on social media by constructing and analyzing semantic networks of vaccine information from highly shared websites of Twitter users in the United States; and to assist public health communication of vaccines. BACKGROUND:Vaccine hesitancy continues to contribute to subopti...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.05.052
更新日期:2017-06-22 00:00:00
abstract:INTRODUCTION:Immunization education for physicians-in-training is crucial to address vaccine concerns in clinical practice. Vaccine education is not standardized across residency programs. The Collaboration for Vaccination Education and Research (CoVER) team developed an online curriculum for pediatric (Peds) and famil...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.09.043
更新日期:2020-10-27 00:00:00
abstract:OBJECTIVES:To determine the proportion of children whose parents prefer them to receive live, attenuated influenza vaccine (LAIV) or inactivated influenza vaccine (IIV), examine reasons for preferences, and determine what percentage of vaccinated children receive other than the preferred type of vaccine and why. METHO...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.10.042
更新日期:2018-11-19 00:00:00
abstract::Vaccine adjuvants are essential for enhancing immune responses during vaccination. However, only a limited number of safe and effective adjuvants, especially mucosal adjuvants, are available for use in vaccines. The development of a practically applicable mucosal adjuvant is therefore urgently needed. Here, we showed ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.05.075
更新日期:2018-07-05 00:00:00
abstract::Pneumococcal type 1 pilus proteins have been proposed as potential vaccine candidates. Following conjugate pneumococcal vaccination, the prevalence of the pneumococcal type 1 pilus declined dramatically, a decline associated with the elimination of vaccine-type (VT) strains. Here we show that between 2004 and 2007, th...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.04.042
更新日期:2010-07-05 00:00:00
abstract::Cholera toxin B subunit (CTB) and Escherichia coli heat-labile toxin (LTB) (2 micrograms), each supplemented with a trace amount of cholera toxin (CT) (0.02-20 ng), were examined for the adjuvant effect on antibody (Ab) response against influenza inactivated HA (haemagglutinin) vaccine in Balb/c mice. Each mouse recei...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(94)90118-x
更新日期:1994-04-01 00:00:00
abstract::Chikungunya virus, transmitted by mosquitoes to man, causes an acute illness characterized by fever, rash and striking joint symptoms. US Military investigators developed, manufactured at The Salk Institute-Government Services Division (TSI-GSD), and tested the live, attenuated Chikungunya Vaccine TSI-GSD-218. The man...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.08.025
更新日期:2012-10-19 00:00:00
abstract:BACKGROUND:We have developed a new oral vaccine against enterotoxigenic Escherichia coli (ETEC), which is the most common cause of bacterial diarrhea in children in developing countries and in travelers. METHODS:The vaccine was tested for safety and immunogenicity alone and together with double-mutant heat-labile toxi...
journal_title:Vaccine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.vaccine.2014.10.069
更新日期:2014-12-12 00:00:00
abstract::Viral hepatitis B is an enigmatic disease in which the host's own immune response to persistent viral infection may bring about host destruction through antiviral inflammatory responses which might otherwise present as a benign or inapparent disease. The simple solution to the hepatitis B problem is by immunoprophylax...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/s0264-410x(03)00529-2
更新日期:2003-12-01 00:00:00
abstract::The efficacy of a licensed human anthrax vaccine (Anthrax Vaccine Adsorbed (AVA)) was tested in guinea pigs, rabbits, and rhesus macaques against spore challenge by Bacillus anthracis isolates of diverse geographical origin. Initially, groups of Hartley guinea pigs were vaccinated at 0 and 4 weeks with AVA, then chall...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(01)00021-4
更新日期:2001-04-30 00:00:00
abstract:BACKGROUND:Although the mortality from diarrheal diseases has been decreasing dramatically in Iran, it still represents an important proportion of disease burden in children <5 years old. Rotavirus vaccines are among the most effective strategies against diarrheal diseases in specific epidemiological conditions. This s...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.12.035
更新日期:2015-05-07 00:00:00
abstract::Since the prognosis of patients with Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL) still remains poor, new relapse prevention strategies are needed. We evaluated the pre-immunization of mice with DNA-based vaccines subsequently challenged by the syngeneic Ph+ ALL cell line BM185. Ballistic t...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.06.094
更新日期:2008-08-26 00:00:00
abstract::Effective immunoprophylaxis directed against the pre-erythrocytic stages of the malaria parasite requires a vaccine that can elicit humoral and cell mediated immunity in individuals of diverse genetic background. In order for a synthetic peptide malaria vaccine to meet these requirements, problems associated with gene...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(97)00238-7
更新日期:1998-04-01 00:00:00
abstract::An effective virus-like particle (VLP) based prophylactic vaccine designed to protect against persistent infection with human papillomavirus (HPV) types 16 and 18 and subsequent lesion development will need to induce a strong humoral and cellular immune response capable of providing long-term protection. Our objective...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2006.06.005
更新日期:2006-08-14 00:00:00
abstract::Protection against diseases caused by the avian viruses, Marek's disease, Infectious laryngotracheitis, chicken anemia and turkey meningoencephalitis is achieved by live vaccines. The application quality is important to assure proper uptake in commercial flocks. We describe a novel evaluation method for the vaccinatio...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.12.052
更新日期:2018-01-29 00:00:00
abstract::The CFA/I fimbria promotes the attachment of enterotoxigenic Escherichia coli (ETEC) to the surface of human enterocytes. The generation of a protective immune response requires the induction of antibodies able to block the CFA/I-mediated binding of ETEC to receptors located on the small intestine epithelium or on the...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(00)00244-9
更新日期:2000-11-22 00:00:00
abstract::Sporozoite vaccination of both humans and rodents elicits potent anti-malarial immunity, but the dose of sporozoites and the number of immunizations required varies with vaccination approach. Here we examine the immunological basis for superior protection afforded from single-dose vaccination with virulent sporozoites...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.11.058
更新日期:2014-01-16 00:00:00
abstract::The role of in vivo-induced ApxIV toxin of Actinobacillus pleuropneumoniae in protective immunity was evaluated in pigs by administering it alone or added to a multicomponent recombinant subunit vaccine composed of recombinant ApxI, ApxII, ApxIII toxin, and 42-kDa outer membrane protein (OMP). The pigs were immunized ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.07.065
更新日期:2009-09-25 00:00:00
abstract::The hepatitis E virus (HEV) vaccine, Hecolin(®), was licensed in China for the prevention of HEV infection and HEV-related diseases with demonstrated safety and efficacy [1,2]. The vaccine is composed of a truncated HEV capsid protein, p239, as the sole antigen encoded by open reading frame 2 and produced using Escher...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.05.064
更新日期:2014-07-07 00:00:00
abstract::Host antiviral genes are important regulators of antiviral immunity and plausible genetic determinants of immune response heterogeneity after vaccination. We genotyped and analyzed 307 common candidate tagSNPs from 12 antiviral genes in a cohort of 745 schoolchildren immunized with two doses of measles-mumps-rubella (...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.09.043
更新日期:2011-11-08 00:00:00
abstract::We cloned six mycobacterial antigens into a mammalian expression vector as fusion proteins with the enhanced green fluorescent protein (EGFP). Plasmid DNA was injected intramuscularly, and the injection sites were examined 1 week later. Expression of each antigen-EGFP fusion protein was visualized as green fluorescenc...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(02)00253-0
更新日期:2002-08-19 00:00:00
abstract::Respiratory syncytial virus (RSV) is a leading viral cause of respiratory morbidity and mortality in infants and young children worldwide. Low and middle income countries (LMICs) account for approximately 99% of the global mortality estimates in this population, with up to 200,000 RSV deaths per year. The vaccine prod...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2017.02.068
更新日期:2019-11-28 00:00:00
abstract::Clinical and post-licensure data have demonstrated that AS03-adjuvanted inactivated split virion vaccines, many with reduced antigen content, are effective against influenza infection. The objective of this review is to provide a comprehensive assessment of the safety of trivalent seasonal, monovalent pre-pandemic and...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2019.04.048
更新日期:2019-05-21 00:00:00
abstract::Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prev...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/s0264-410x(02)00389-4
更新日期:2002-12-19 00:00:00
abstract:BACKGROUND:Combination antiretroviral therapy (cART) is the main therapeutic management tool for HIV/AIDS. Despite its success in controlling viral load and disease progression, cART is expensive, associated with a range of significant side effects and depends for its efficacy on the patient's life-long commitment to h...
journal_title:Vaccine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.vaccine.2013.09.057
更新日期:2013-11-19 00:00:00
abstract::A synthetic T cell immunogen (TCI) has been designed as a candidate DNA-based vaccine against Human immunodeficiency virus (HIV)-1 using cytotoxic T lymphocytes (CD8(+) CTL) and T-helper lymphocytes (CD4(+) Th) epitopes retrieved from the Los Alamos HIV Molecular Immunology Database. The protein 392 amino acids in len...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2003.09.048
更新日期:2004-04-16 00:00:00