DNA immunisation against the CFA/I fimbriae of enterotoxigenic Escherichia coli (ETEC).

abstract：:Cholera is a potentially lethal diarrhea disease caused by the gram-negative bacterium Vibrio cholerae. The need for an effective cholera vaccine is clearly indicated but the challenges of eliciting both systemic and mucosal immune responses remains a significant challenge. In the current report, we discovered that a ...

journal_title：Vaccine

authors： Xu G,Wang S,Zhuang L,Hackett A,Gu L,Zhang L,Zhang C,Wang H,Huang Z,Lu S

更新日期：2009-06-12 00:00:00

abstract：:Small fusions to the N-terminal end of the host-protective antigen (VP2) of infectious bursal disease virus lead to stable expression of VP2 in Escherichia coli and yeast, and reduce the levels of inclusion body formation in E. coli in comparison to VP2 constructs with larger N-terminal fusions. VP2 produced with smal...

journal_title：Vaccine

authors： Azad AA,McKern NM,Macreadie IG,Failla P,Heine HG,Chapman A,Ward CW,Fahey KJ

更新日期：1991-10-01 00:00:00

abstract：:A new rabies vaccine was developed from Vero cells adhered to microcarriers, cultivated in a bioreactor in serum-free medium and infected with the PV/VERO-Paris rabies virus strain. The viral suspensions were concentrated by tangential filtration, purified by chromatography and inactivated with beta-propiolactone. In ...

journal_title：Vaccine

authors： Frazatti-Gallina NM,Mourão-Fuches RM,Paoli RL,Silva ML,Miyaki C,Valentini EJ,Raw I,Higashi HG

更新日期：2004-12-09 00:00:00

abstract：:Human papillomavirus type 16 (HPV16)-transformed mouse TC-1 cells are extensively used in the evaluation of efficacy of experimental vaccines against tumours induced by HPVs. As these cells strongly express MHC class I molecules and downregulation of MHC class I surface expression is one of the important mechanisms th...

journal_title：Vaccine

authors： Smahel M,Síma P,Ludvíková V,Marinov I,Pokorná D,Vonka V

更新日期：2003-03-07 00:00:00

abstract：:Financial sustainability plans (FSPs) were developed by over 50 of the world's poorest countries receiving funding support from the Global Alliance for Vaccines and Immunization (GAVI) to introduce new and underused vaccines, injection safety and immunization service support between 2000 and 2006. These plans were ana...

journal_title：Vaccine

authors： Kamara L,Milstien JB,Patyna M,Lydon P,Levin A,Brenzel L

更新日期：2008-12-02 00:00:00

abstract：:Because of demonstrable cross-reactivity of cellular antigens contained in B subunit-killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines with antigens of various non-cholera species of the family Vibrionaceae (NCV), the protection conferred by the vaccines against diarrhoea associated with ...

journal_title：Vaccine

authors： Clemens JD,Harris JR,Kay BA,Chakraborty J,Sack DA,Ansaruzzaman M,Rahman R,Stanton BF,Khan MU,Khan MR

更新日期：1989-04-01 00:00:00

abstract：:The immunogenicity of 23-valent pneumococcal polysaccharide vaccine was assessed in 57 HIV-1 infected former intravenous drug users and in 20 HIV-1 negative controls. The effect of vaccination on HIV-1 infection was studied in a subgroup of 38 patients, 60% of whom under highly active antiretroviral therapy (HAART). A...

journal_title：Vaccine

authors： Amendola A,Tanzi E,Zappa A,Colzani D,Boschini A,Musher DM,Zanetti AR

更新日期：2002-11-01 00:00:00

abstract：:Cimetidine (CIM) is an H2-receptor antagonist with a long history of clinical use in peptic ulcer disease. In addition to its inhibitory effect upon gastric acid secretion, CIM can also block histamine-mediated immunosuppression by inhibiting H2 receptors on suppressor T cells. CIM results in immunoaugmentation of bot...

journal_title：Vaccine

authors： Drabick JJ,Tang DB,Moran EE,Trofa AF,Foster JS,Zollinger WD

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:A recent mumps outbreak in Israel despite an ongoing national program of a 2-dose universal childhood vaccination policy since 1988, raised questions regarding population immunity among young adults. OBJECTIVE:To assess the seroprevalence of mumps antibodies among young Israeli adults born after 1987 in ord...

journal_title：Vaccine

authors： Levine H,Ankol OE,Rozhavski V,Davidovitch N,Aboudy Y,Zarka S,Balicer RD

更新日期：2011-03-24 00:00:00

abstract：:The rectum as an effective site for induction of systemic and local immunity has received little attention. Rectal immunization with microspheres-containing ovalbumin (MS-OVA) was tested for its ability to elicit systemic and mucosal immune responses. Rectal immunization with MS-OVA enhanced both Th2 dominant OVA-spec...

journal_title：Vaccine

authors： Nakase H,Okazaki K,Tabata Y,Uchida K,Uose S,Ohana M,Nishi T,Watanabe T,Matsuura M,Hisatsune H,Matsumura K,Itoh T,Kawanami C,Chiba T

更新日期：2001-11-12 00:00:00

abstract：:We have designed a peptide-based immunotherapeutic vaccine for treatment of androgen-responsive prostate cancer. The vaccine targets the luteinizing hormone-releasing hormone (LHRH) decapeptide that results in an androgen-deprivation immunotherapy. The design elements of the peptide immunogens are the LHRH peptide or ...

journal_title：Vaccine

authors： Finstad CL,Wang CY,Kowalski J,Zhang M,Li ML,Li XM,Xia WG,Bosland MC,Murthy KK,Walfield AM,Koff WC,Zamb TJ

更新日期：2004-03-12 00:00:00

abstract：:Whole killed meningococci (Nm) and pertussis bacteria (Bp) were tested for mucosal immunogenicity and as mucosal adjuvants for an inactivated influenza virus vaccine given intranasally to unanaesthetized mice. Virus was given alone, or simply mixed with one of the bacterial preparations, in four doses at weekly interv...

journal_title：Vaccine

authors： Berstad AK,Andersen SR,Dalseg R,Dromtorp S,Holst J,Namork E,Wedege E,Haneberg B

更新日期：2000-03-17 00:00:00

abstract：:In a phase III, double blind, randomized, noninferiority, multi-centre clinical trial, 817 infants were included and randomly assigned to vaccination with DTaP-IPV(Vero) (N=410) or DTaP-IPV(Mkc) (N=407) vaccines (Statens Serum Institut (SSI), Denmark) in the right thigh. All infants were vaccinated with Act-HIB (Sanof...

journal_title：Vaccine

authors： Pietrzyk JJ,Wysocki J,Pejcz J,Galaj A,Majda-Stanislawska E,Käyhty H,Thierry-Carstensen B,Jensen AM

更新日期：2008-09-26 00:00:00

abstract：:By the strategy "reverse vaccinology" a number of new antigens have been identified in Neisseria meningitidis, which are potential candidates for a highly needed broad-spectrum meningococcal vaccine. In the present study we examined the prevalence, sequence constancies and variations of the genes encoding three of the...

journal_title：Vaccine

authors： Jacobsson S,Thulin S,Mölling P,Unemo M,Comanducci M,Rappuoli R,Olcén P

更新日期：2006-03-15 00:00:00

abstract：:The effectiveness of the influenza vaccine used in the 2001-2002 influenza season in Japan was investigated in a large-scale, geographically widely distributed, Internet-based study. Data were collected from 8841 of 9902 subjects registered by 38 clinics prior to the start of influenza season. Subjects were categorize...

journal_title：Vaccine

authors： Kawai N,Ikematsu H,Iwaki N,Satoh I,Kawashima T,Tsuchimoto T,Kashiwagi S

更新日期：2003-11-07 00:00:00

abstract：:The principle of deliberately infecting humans with infectious agents in a controlled setting, so-called controlled human infections (CHI), is not novel. Many CHI models have a long history and were established decades ago such as the intentional exposure to yellow fever and dengue performed in the 1900's (Reed, 1902)...

journal_title：Vaccine

authors： Roestenberg M,Mo A,Kremsner PG,Yazdanbakhsh M

更新日期：2017-12-18 00:00:00

abstract：:Recipients of renal transplants were vaccinated with 20 ng hepatitis B surface antigen aluminium-adsorbed vaccine in order to gauge their resistance to hepatitis B infection, to which these patients are at high risk. The patients were given three 40 micrograms doses of the vaccine over a period of six months and their...

journal_title：Vaccine

authors： Feuerhake A,Muller R,Lauchart W,Pichlmayr R,Schmidt FW

更新日期：1984-12-01 00:00:00

abstract：:Chlamydia trachomatis causes respiratory and sexually transmitted infections. Here, we tested a vaccine formulated with the recombinant major outer membrane protein from C. trachomatis mouse pneumonitis (CT-MoPn) for its ability to protect mice against an intranasal (i.n.) challenge. The adjuvants CpG and Montanide we...

journal_title：Vaccine

authors： Ralli-Jain P,Tifrea D,Cheng C,Pal S,de la Maza LM

更新日期：2010-11-10 00:00:00

abstract：BACKGROUND:The Post-Licensure Rapid Immunization Safety Monitoring (PRISM) program is the immunization safety monitoring component of FDA's Mini-Sentinel project, a program to actively monitor the safety of medical products using electronic health information. FDA sought to assess the surveillance capabilities of this ...

journal_title：Vaccine

authors： Baker MA,Nguyen M,Cole DV,Lee GM,Lieu TA

更新日期：2013-12-30 00:00:00

abstract：:Measles is one of the most important diseases of mankind, which is so highly contagious and evokes such persistent immunity that the virus cannot be sustained in a population of less than about 500,000 persons. The first of the licensed live virus vaccines against measles was developed empirically and was approved in ...

journal_title：Vaccine

authors： Hilleman MR

更新日期：2001-12-12 00:00:00

abstract：BACKGROUND AND AIMS:Simplified vaccine preparation steps would save time and reduce potential immunisation errors. The aim of the study was to assess vaccine preparation time with fully-liquid hexavalent vaccine (DTaP-IPV-HB-PRP-T, Sanofi Pasteur MSD) versus non-fully liquid hexavalent vaccine that needs reconstitution...

journal_title：Vaccine

authors： De Coster I,Fournie X,Faure C,Ziani E,Nicolas L,Soubeyrand B,Van Damme P

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:We have developed a new oral vaccine against enterotoxigenic Escherichia coli (ETEC), which is the most common cause of bacterial diarrhea in children in developing countries and in travelers. METHODS:The vaccine was tested for safety and immunogenicity alone and together with double-mutant heat-labile toxi...

journal_title：Vaccine

authors： Lundgren A,Bourgeois L,Carlin N,Clements J,Gustafsson B,Hartford M,Holmgren J,Petzold M,Walker R,Svennerholm AM

更新日期：2014-12-12 00:00:00

abstract：BACKGROUND:A vaccine manufacturer in China and regulatory authorities have been the focus of widespread outrage due to a vaccine scandal. We conducted a rapid survey during a time of intense mainstream and social media attention to determine whether the public's confidence in vaccines was affected. METHODS:We selected...

journal_title：Vaccine

authors： Han B,Wang S,Wan Y,Liu J,Zhao T,Cui J,Zhuang H,Cui F

更新日期：2019-08-23 00:00:00

abstract：:Human metapneumovirus (HMPV) is a major cause of morbidity and mortality from acute lower respiratory tract illness, with most individuals seropositive by age five. Despite the presence of neutralizing antibodies, secondary infections are common and can be severe in young, elderly, and immunocompromised persons. Precl...

journal_title：Vaccine

authors： Hastings AK,Gilchuk P,Joyce S,Williams JV

更新日期：2016-05-23 00:00:00

abstract：:The objective of this paper is to review adaptive immunity of young animals using examples from my own experience and from the literature. Trials carried out by us with a modified live and inactivated canine parvovirus vaccine in newborn puppies provide evidence of the immune capacity of these puppies. With regard to ...

journal_title：Vaccine

authors： Chappuis G

更新日期：1998-08-01 00:00:00

abstract：:Adult patients with mucosal leishmaniasis (ML) were enrolled in a randomized, double-blind, placebo-controlled, dose-escalating clinical trial and were randomly assigned to receive three injections of either the LEISH-F1+MPL-SE vaccine (consisting of 5, 10, or 20 μg recombinant Leishmania polyprotein LEISH-F1 antigen+...

journal_title：Vaccine

authors： Llanos-Cuentas A,Calderón W,Cruz M,Ashman JA,Alves FP,Coler RN,Bogatzki LY,Bertholet S,Laughlin EM,Kahn SJ,Beckmann AM,Cowgill KD,Reed SG,Piazza FM

更新日期：2010-10-28 00:00:00

abstract：:Epidemic influenza occurs annually throughout the world and is accompanied by excess morbidity and mortality. Increasing the antigen content and topical administration of vaccine are two strategies being explored to improve the immune responses to trivalent inactivated influenza vaccine (TIV). We conducted a randomize...

journal_title：Vaccine

authors： Atmar RL,Keitel WA,Cate TR,Munoz FM,Ruben F,Couch RB

更新日期：2007-07-20 00:00:00

abstract：:We assessed HPV 16 and 18 antibody responses of female subjects enrolled in a 2- vs. 3-dose quadrivalent HPV (Q-HPV) vaccine trial (ClinicalTrials.gov NCT00501137) using the Merck competitive Luminex (cLIA) and total IgG Luminex (TIgG) immunoassays, and a pseudovirus neutralizing antibody (PsV NAb) assay. Subjects wer...

journal_title：Vaccine

authors： Krajden M,Cook D,Yu A,Chow R,Su Q,Mei W,McNeil S,Money D,Dionne M,Palefsky J,Karunakaran K,Kollmann T,Ogilvie G,Petric M,Dobson S

更新日期：2014-01-23 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating epizootic of porcine species. Current vaccines are inadequate to control the disease burden and outbreaks in the field. We report a novel baculovirus vaccine vector with White spot syndrome virus immediate early 1 shuttle promoter, wit...

journal_title：Vaccine

authors： Karuppannan AK,Qiang J,Chang CC,Kwang J

更新日期：2013-11-04 00:00:00

abstract：:Intranasal inactivated influenza vaccines have the advantage over parenteral vaccines in that they are not associated with the pain of an injection. However, they would be most useful if they were available for all age groups, including high-risk groups, and also would provide cross-protection against variant virus st...

journal_title：Vaccine

authors： Tamura S

更新日期：2010-08-31 00:00:00