Abstract:
:Hepatitis B surface antigen (HBsAg) was detected in 3.3% of 7162 pregnant Tunisian women tested and HBeAg in 9.6% of the HBsAg-positive mothers. Family members of 46 of these HBsAg-positive mothers (33 husbands and 61 children aged 1-6 years) were investigated for the presence of HBV markers. HBsAg was detected in 21% of the children and 18% of the husbands. Fifty children born to HBsAg-positive mothers received hepatitis B vaccine at birth, at the age of 2-3 months and at the age of 9 months. After immunization, anti-HBs were detected in 92% of them with an anti-HBs geometric mean titre of 415 mIU ml-1. Compared with the HBsAg carrier state in older siblings, the protective efficacy was estimated to be 60%. It was 100% for infants born to HBeAg-negative mothers, but only 31% for those born to HBeAg-positive mothers. For a better efficacy, the schedule of the EPI needs to be modified to include an immunization session at 1 month of age.
journal_name
Vaccinejournal_title
Vaccineauthors
Coursaget P,Gharbi Y,Khrouf N,Depril N,Boukhris N,Fritzell B,Kastally Rdoi
10.1016/0264-410x(94)90205-4subject
Has Abstractpub_date
1994-01-01 00:00:00pages
275-8issue
3eissn
0264-410Xissn
1873-2518pii
0264-410X(94)90205-4journal_volume
12pub_type
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