Montanide ISA 720 vaccines: quality control of emulsions, stability of formulated antigens, and comparative immunogenicity of vaccine formulations.

abstract：:Potent liposomal PorA formulations containing various lipopolysaccharide (LPS) derivatives were developed. The following adjuvants were compared: the commonly used aluminum phosphate (AlPO(4)), and three LPS like adjuvants: monophosphoryl lipid A (MPL), lipopolysaccharide (galE LPS) and the less toxic LPS mutant lpxL1...

journal_title：Vaccine

authors： Arigita C,Luijkx T,Jiskoot W,Poelen M,Hennink WE,Crommelin DJ,Ley Pv,Els Cv,Kersten GF

更新日期：2005-10-17 00:00:00

abstract：:One hundred and fourteen children, born to HBsAg-positive mothers received in the first year of life passive active prophylaxis for hepatitis B virus (HBV). They have been followed up to 10 years. A booster dose given in a cohort at the 5th year does not seem to increase protection against HBV. No difference in immuno...

journal_title：Vaccine

authors： Resti M,Azzari C,Mannelli F,Rossi ME,Lionetti P,Vierucci A

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:We tested the hypotheses that consistency and strength of clinician recommendation of the human papillomavirus (HPV) vaccination would be associated with vaccine delivery rates. METHODS:From October 2015 through January 2016, we conducted a survey of primary care clinicians (n=227) in Southeastern Minnesota to...

journal_title：Vaccine

authors： Finney Rutten LJ,St Sauver JL,Beebe TJ,Wilson PM,Jacobson DJ,Fan C,Breitkopf CR,Vadaparampil ST,MacLaughlin KL,Jacobson RM

更新日期：2017-10-27 00:00:00

abstract：:An ELISA-immunocapture assay was developed for quantification of influenza neuraminidases (N2 and B), with a sensitivity about 10 ng neuramidase(NA)/ml. This sensitive and specific assay was applied to several trivalent vaccine preparations (1997/1998 and 1998/1999). It was shown capable to detect 3.5-6.9 microg NA/ml...

journal_title：Vaccine

authors： Aymard M

更新日期：2002-05-15 00:00:00

abstract：:The immunogenicity and protective efficacy of a nucleic acid vaccine encoding the herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) gene under the control of the CMV immediate early gene promoter was examined. Mice immunized three times by intramuscular injection with the vaccine developed an HSV specific IgG bu...

journal_title：Vaccine

authors： Bourne N,Milligan GN,Schleiss MR,Bernstein DI,Stanberry LR

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Zika virus vaccine development is underway. We examined interest in receiving a Zika virus vaccine (after one becomes commercially available) among students at a large public university in Northern Virginia. METHODS:An online survey of Zika virus-related knowledge, attitudes, and interest in receiving a Zik...

journal_title：Vaccine

authors： Painter JE,Plaster AN,Tjersland DH,Jacobsen KH

更新日期：2017-02-07 00:00:00

abstract：:Two clinical studies were undertaken to evaluate the immunogenicity of an adult-type dTpa booster vaccine (Boostrix by GlaxoSmithKline Biologicals). Blood samples taken prior to vaccination showed that 24.4 and 13.0% of subjects were seronegative for diphtheria and tetanus antibodies, respectively. Moreover, about one...

journal_title：Vaccine

authors： Van Damme P,Burgess M

更新日期：2004-01-02 00:00:00

abstract：:In this study, we compare four different adjuvants, LT(R192G), CpG ODN, MPL((R))TDM, and alum, for their ability to affect the magnitude, distribution, and duration of antibody responses against F1-V, the lead-candidate antigen for the next generation vaccine against plague, in a murine model. In addition, three diffe...

journal_title：Vaccine

authors： Uddowla S,Freytag LC,Clements JD

更新日期：2007-11-19 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) is still one of the most serious pathogens in cattle, meriting the development of improved vaccines. Recently, we developed a new adjuvant consisting of poly[di(sodium carboxylatoethylphenoxy)]-phosphazene (PCEP), either CpG ODN or poly(I:C), and an immune defense regulator (IDR) pep...

journal_title：Vaccine

authors： Snider M,Garg R,Brownlie R,van den Hurk JV,van Drunen Littel-van den Hurk S

更新日期：2014-11-28 00:00:00

abstract：:A small number of serotypes are responsible for most invasive pneumococcal disease in children worldwide. Serotypes 1 and 5 were among the first pneumococcal serotypes to be identified, reflecting their great prominence as causes of disease in the early part of the 20th century. In the antibiotic era, these serotypes ...

journal_title：Vaccine

authors： Hausdorff WP

更新日期：2007-03-22 00:00:00

abstract：OBJECTIVE:To examine the effectiveness of pneumococcal polysaccharide vaccine (PPV) among approximately 40,000 community-dwelling men aged 45 years and older in the California Men's Health Study (CMHS) cohort. METHODS:All participants completed an extensive questionnaire at baseline (2002-2003) and were followed for t...

journal_title：Vaccine

authors： Hechter RC,Chao C,Jacobsen SJ,Slezak JM,Quinn VP,Van Den Eeden SK,Tseng HF

更新日期：2012-08-17 00:00:00

abstract：:Proteins isolated from the midgut of Glossina pallidipes were used to immunize rabbits and their efficacy as vaccine candidate(s) against the fly, and their potential to block transmission of Trypanosoma brucei rhodesiense assessed. Two fractions, detergent (DET) and aqueous (AQ) fractions were separated using a non-i...

journal_title：Vaccine

authors： Kinyua JK,Nguu EK,Mulaa F,Ndung'u JM

更新日期：2005-05-31 00:00:00

abstract：:Neuromuscular diseases (NMDs) encompass a broad spectrum of conditions. Because infections may be relevant to the final prognosis of most NMDs, vaccination appears to be the simplest and most effective solution for protecting NMD patients from vaccine-preventable infections. However, very few studies have evaluated th...

journal_title：Vaccine

authors： Esposito S,Bruno C,Berardinelli A,Filosto M,Mongini T,Morandi L,Musumeci O,Pegoraro E,Siciliano G,Tonin P,Marrosu G,Minetti C,Servida M,Fiorillo C,Conforti G,Scapolan S,Ansaldi F,Vianello A,Castaldi S,Principi N,T

更新日期：2014-10-14 00:00:00

abstract：:Japanese encephalitis (JE) is a fatal mosquito-borne disease that is vaccine-preventable. The natural infection rate is a critical factor for evaluations of the necessity for vaccination. Detection of antibodies to virus nonstructural (NS) proteins is a theoretical strategy to survey natural infections among populatio...

journal_title：Vaccine

authors： Konishi E,Kitai Y

更新日期：2009-11-23 00:00:00

abstract：:A choice-format, conjoint-analysis survey was developed and fielded to estimate how features of human papillomavirus (HPV) vaccines affect mothers' perceived benefit and stated vaccine uptake for daughters. Data were collected from a national sample of 307 U.S. mothers of girls aged 13-17 years who had not yet receive...

journal_title：Vaccine

authors： Brown DS,Johnson FR,Poulos C,Messonnier ML

更新日期：2010-02-17 00:00:00

abstract：:Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula that affects sheep, cattle, goats, camels, and humans. Effective vaccination of susceptible ruminants is important for the prevention of RVF outbreaks. Live-attenuated RVF vaccines are in general highly immunogenic...

journal_title：Vaccine

authors： Ly HJ,Nishiyama S,Lokugamage N,Smith JK,Zhang L,Perez D,Juelich TL,Freiberg AN,Ikegami T

更新日期：2017-12-04 00:00:00

abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells of the immune system that are efficient at presenting peptide-antigen for the activation of T cells and are often the cell type of choice for vaccine targeting by virtue of high expression levels of MHC and costimulatory molecules. Since the level o...

journal_title：Vaccine

authors： Neethling FA,Ramakrishna V,Keler T,Buchli R,Woodburn T,Weidanz JA

更新日期：2008-06-13 00:00:00

abstract：:The nontoxic N-terminal fragment of Bacillus anthracis edema factor (EF) was evaluated as a candidate antigen in an anthrax vaccine using a replication-incompetent adenoviral vector. An E1/E3 deleted adenovirus (Ad/EFn) encoding the N-terminal region 1-254 amino acids of the edema factor (EFn) was constructed using th...

journal_title：Vaccine

authors： Zeng M,Xu Q,Hesek ED,Pichichero ME

更新日期：2006-01-30 00:00:00

abstract：:Although the currently used live attenuated measles vaccines are safe and effective, they are dependent on cold chain maintenance and are often ineffective in young infants due to interference by maternal antibody. Therefore, besides vector-based vaccines, different new generation non-replicating candidate measles vac...

journal_title：Vaccine

authors： Stittelaar KJ,de Swart RL,Vos HW,van Amerongen G,Sixt N,Wild TF,Osterhaus AD

更新日期：2002-05-15 00:00:00

abstract：:It is well documented that adjuvants improve the immune response generated by traditional viral vaccines, but less is known about the effects of adjuvants on the immune response elicited by DNA vaccines. In this study, we have investigated the use of RN-205 (immunomodulator containing a membrane rich in lipopolysaccha...

journal_title：Vaccine

authors： Zamorano P,Taboga O,Domínguez M,Romera A,Puntel M,Tami C,Mongini C,Waldner C,Palma E,Sadir A

更新日期：2002-06-21 00:00:00

abstract：:We hypothesized that the ability of BCG vaccination to protect against Mycobacterium tuberculosis is less in hosts exposed to chronic helminthes infection compared to unexposed individuals. To test this hypothesis we evaluated the efficacy of BCG vaccination in protecting against M. tuberculosis challenge in Schistoso...

journal_title：Vaccine

authors： Elias D,Akuffo H,Pawlowski A,Haile M,Schön T,Britton S

更新日期：2005-02-03 00:00:00

abstract：OBJECTIVE:Implementing national-level vaccination programs involves long-term investment, which can be a significant financial burden, particularly in resource-limited settings. Although many studies have assessed the economic impacts of providing vaccinations, evidence on the positive and negative implications of huma...

journal_title：Vaccine

authors： Chootipongchaivat S,Chantarastapornchit V,Kulpeng W,Ceria JA,Tolentino NI,Teerawattananon Y

更新日期：2016-09-14 00:00:00

abstract：:Recent findings in the interactions between pathogens and the innate immune system, particularly with dendritic cells (DC), have opened new opportunities for adjuvants designs. We have elaborated a new approach, in which gangliosides are incorporated into the outer membrane complex of Neisseria meningitidis to form ve...

journal_title：Vaccine

authors： Mesa C,de León J,Rigley K,Fernández LE

更新日期：2006-04-12 00:00:00

abstract：:We report the use of recombinant scorpion toxins in the form of fusion proteins as antigens for immunisation in rabbits and mice: the aim was to produce in these animal models protective antisera against the most lethal alpha-type toxins in the venom from the North African scorpion Androctonus australis. The cDNAs enc...

journal_title：Vaccine

authors： Legros C,Kaabi H,El Ayeb M,Céard B,Vacher H,Bougis PE,Martin-Eauclaire MF

更新日期：2001-12-12 00:00:00

abstract：:The development of strategies to augment the immunogenicity of plasmid DNA vaccines is critical for improving their clinical utility. One such strategy involves the coadministration of plasmid cytokine adjuvants with DNA vaccines. Although a large number of plasmid cytokines have shown promise as adjuvants in preclini...

journal_title：Vaccine

authors： Barouch DH,Truitt DM,Letvin NL

更新日期：2004-08-13 00:00:00

abstract：:NetB (necrotic enteritis toxin B) is a recently identified β-pore-forming toxin produced by Clostridium perfringens. This toxin has been shown to play a major role in avian necrotic enteritis. In recent years, a dramatic increase in necrotic enteritis has been observed, especially in countries where the use of antimic...

journal_title：Vaccine

authors： Fernandes da Costa SP,Mot D,Bokori-Brown M,Savva CG,Basak AK,Van Immerseel F,Titball RW

更新日期：2013-08-20 00:00:00

abstract：:Some technological and immunological problems facing the preparation of subunit viral vaccines are discussed. Solubilization of enveloped virus glycoproteins with various detergents has been studied. It has been demonstrated that a novel non-ionic detergent, MESK, can be used to prepare the glycoproteins of enveloped ...

journal_title：Vaccine

authors： Berezin VE,Zaides VM,Isaeva ES,Artamonov AF,Zhdanov VM

更新日期：1988-10-01 00:00:00

abstract：:During the 2000/2001 influenza season in Japan, children ranging in age from 6 months to 13 years with fever exceeding 37.5 degrees C were recruited. Vaccine efficacy was evaluated by comparing the rates of pre-seasonal vaccination between groups stratified by fever severity. Seven hundred and sixty one patients (33.1...

journal_title：Vaccine

authors： Kamada M,Nagai T,Kumagai T,Igarashi M,Ihara T,Okafuji T,Ochiai H,Sakiyama H,Shimomura K,Suzuki E,Torigoe S,Miyazaki C,Miyata A,Yuri K,Ito Y,Nakayama T,Kase T,Okuno Y

更新日期：2006-04-24 00:00:00

abstract：:Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with chil...

journal_title：Vaccine

authors： Boelsen LK,Dunne EM,Lamb KE,Bright K,Cheung YB,Tikoduadua L,Russell FM,Mulholland EK,Licciardi PV,Satzke C

更新日期：2015-10-13 00:00:00

abstract：BACKGROUND:The Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA) assessed vaccine-type community-acquired pneumonia (VT-CAP) and vaccine-type invasive pneumococcal disease (VT-IPD) prevention with 13-valent pneumococcal conjugate vaccine (PCV13) in adults aged ⩾65years. We report vaccine efficacy (VE) ...

journal_title：Vaccine

authors： Webber C,Patton M,Patterson S,Schmoele-Thoma B,Huijts SM,Bonten MJ,CAPiTA Study Group.

更新日期：2017-03-01 00:00:00