Controlled organization of multimolecular complexes of enveloped virus glycoproteins: study of immunogenicity.

abstract：:We recently reported that administration of low doses of myotoxins at vaccination sites potentiated antigen-specific T-cell immunity induced by genetic cancer vaccines in mice, an effect which was superior to TLR agonists. In the current study, we found unexpectedly that the mechanism of this potent adjuvant effect wa...

journal_title：Vaccine

authors： Qin H,Cha SC,Neelapu SS,Liu C,Wang YH,Wei J,Qin XF,Liu YJ,Kwak LW

更新日期：2010-11-23 00:00:00

abstract：:Leptospirosis is an important zoonotic disease worldwide. Subunit vaccines are an attractive intervention strategy against this disease, but potent, non-toxic adjuvants are necessary components to any effective vaccine. Among various adjuvant candidates, liposomes have garnered recent attention for their capacity as c...

journal_title：Vaccine

authors： Faisal SM,Yan W,McDonough SP,Mohammed HO,Divers TJ,Chang YF

更新日期：2009-10-19 00:00:00

abstract：:Vaccine safety fears following media reports of adverse events led to low (50.3%) coverage in a supplementary measles-rubella immunization campaign in Georgia in 2008. Review of adverse events associated with the campaign identified 432 reports (<0.1% of ∼ 493,000 vaccinees) including 338 (78.2%) cases of syncope. The...

journal_title：Vaccine

authors： Khetsuriani N,Imnadze P,Baidoshvili L,Jabidze L,Tatishili N,Kurtsikashvili G,Lezhava T,Laurent E,Martin R

更新日期：2010-09-07 00:00:00

abstract：:Defining correlates of T cell mediated protection is important in order to accelerate the development of efficient T cell based vaccines conferring long-term immunity. Extensive studies have provided important insight regarding the characteristics and functional properties of the effector and memory CD8 T cells induce...

journal_title：Vaccine

authors： Jahn ML,Steffensen MA,Christensen JP,Thomsen AR

更新日期：2018-05-11 00:00:00

abstract：:Cationic antimicrobial peptides (CAMPs) are active defence components of the innate immune system. Several artificial CAMPs have been designed as antibiotic peptide therapeutics, but none have been reported to exert adjuvant activity in animal models. Here we show for the first time that an artificial CAMP, KLKLLLLLKL...

journal_title：Vaccine

authors： Fritz JH,Brunner S,Birnstiel ML,Buschle M,Gabain Av,Mattner F,Zauner W

更新日期：2004-09-03 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating epizootic of porcine species. Current vaccines are inadequate to control the disease burden and outbreaks in the field. We report a novel baculovirus vaccine vector with White spot syndrome virus immediate early 1 shuttle promoter, wit...

journal_title：Vaccine

authors： Karuppannan AK,Qiang J,Chang CC,Kwang J

更新日期：2013-11-04 00:00:00

abstract：:The conventional treatment for paracoccidioidomycosis, the most prevalent mycosis in Latin America, involves long periods of therapy resulting in sequels and high frequency of relapses. The search for new alternatives of treatment is necessary. Previously, we have demonstrated that the hsp65 gene from Mycobacterium le...

journal_title：Vaccine

authors： Ribeiro AM,Bocca AL,Amaral AC,Souza AC,Faccioli LH,Coelho-Castelo AA,Figueiredo F,Silva CL,Felipe MS

更新日期：2010-02-10 00:00:00

abstract：:Antibodies have the potential to be therapeutic reagents for malaria. Here we describe the production of a novel phage antibody display library against the C-terminal 19kDa region of the Plasmodium yoelii YM merozoite surface protein-1 (MSP1(19)). In vivo studies against homologous lethal malaria challenge show an ant...

journal_title：Vaccine

authors： Vukovic P,Chen K,Qin Liu X,Foley M,Boyd A,Kaslow D,Good MF

更新日期：2002-06-21 00:00:00

abstract：:Enteroviruses elicit protective mucosal immune responses that could be harnessed as part of a strategy to prevent sexual transmission of the human immunodeficiency virus-1 (HIV-1). We report the construction of replication-competent recombinant vectors of coxsackievirus B3 (CVB3) that express one or more portions of t...

journal_title：Vaccine

authors： Miller JP,Geng Y,Ng HL,Yang OO,Krogstad P

更新日期：2009-06-19 00:00:00

abstract：:Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with chil...

journal_title：Vaccine

authors： Boelsen LK,Dunne EM,Lamb KE,Bright K,Cheung YB,Tikoduadua L,Russell FM,Mulholland EK,Licciardi PV,Satzke C

更新日期：2015-10-13 00:00:00

abstract：:A hybrid protein [Met-Ala-(His)(6) OprF(190-342)-OprI(21-83)] consisting of the mature outer membrane protein I (OprI) and amino acids 190-342 of OprF of Pseudomonas aeruginosa was expressed in Escherichia coli and purified by Ni(2+) chelate-affinity chromatography. After several studies in healthy volunteers, as well...

journal_title：Vaccine

authors： Larbig M,Mansouri E,Freihorst J,Tümmler B,Köhler G,Domdey H,Knapp B,Hungerer KD,Hundt E,Gabelsberger J,von Specht BU

更新日期：2001-03-21 00:00:00

abstract：:We investigated the therapeutic effects of romurtide, a synthetic muramyl dipeptide derivative, on experimental thrombocytopenia induced by carboplatin in cynomolgus monkeys. A prolonged thrombocytopenia due to a severe myelosuppression was induced by carboplatin. Romurtide given subcutaneously elevated significantly ...

journal_title：Vaccine

authors： Namba K,Nitanai H,Otani T,Azuma I

更新日期：1996-10-01 00:00:00

abstract：:A formulation of recombinant hepatitis B surface antigen (HBsAg) combined with a novel adjuvant system, SBAS4--a combination of aluminium salt and monophosphoryl lipid A (MPL), was assessed in 27 healthy adult volunteers with a commercial vaccine (Engerix-B) as control. After three doses (0, 1, 6 months schedule), rea...

journal_title：Vaccine

authors： Thoelen S,Van Damme P,Mathei C,Leroux-Roels G,Desombere I,Safary A,Vandepapeliere P,Slaoui M,Meheus A

更新日期：1998-04-01 00:00:00

abstract：:Fluid cholera vaccine was examined for its stability at 4-8 degrees C, 20-25 degrees C and 37 degrees C with regard to the number of organisms present and the total nitrogen content. Ten batches of fluid cholera vaccine manufactured at the Central Research Institute, Kasauli, India were taken for the study. The number...

journal_title：Vaccine

authors： Gupta RK,Maheshwari SC,Sharma SB,Ahuja S,Saxena SN

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:The effectiveness of inactivated influenza vaccine (IIV) immunization in preventing all cause respiratory illness (RI) in children with pre-existing medical conditions has not been fully established and varies from season to season. This study aims to quantify the overall impact of IIV immunization on primar...

journal_title：Vaccine

authors： de Hoog MLA,Venekamp RP,Meijer A,Sanders EAM,Bruijning-Verhagen PCJL

更新日期：2020-04-09 00:00:00

abstract：BACKGROUND AND PURPOSE:Varicella disease is a risk factor for pediatric Arterial Ischemic Stroke (AIS). Isolated case reports have emerged suggesting that varicella vaccination may also pose a risk for AIS. METHODS:This retrospective population-based cohort study assessed the risk of AIS in children who received a var...

journal_title：Vaccine

authors： MacDonald SE,Dover DC,Hill MD,Kirton A,Simmonds KA,Svenson LW

更新日期：2018-05-11 00:00:00

abstract：:The new intradermal DNA delivery technique, termed DNA tattooing might overcome the discrepancy between the encouraging immunogenicity results obtained with DNA vaccines in murine studies and the poor results obtained in non-human primates and humans, the so called "simian barrier". Here, we demonstrate a 10- to 100-f...

journal_title：Vaccine

authors： Verstrepen BE,Bins AD,Rollier CS,Mooij P,Koopman G,Sheppard NC,Sattentau Q,Wagner R,Wolf H,Schumacher TN,Heeney JL,Haanen JB

更新日期：2008-06-19 00:00:00

abstract：:Fertile turkey eggs after 24 days of incubation were vaccinated in ovo with a commercial live attenuated subtype A avian pneumovirus (APV) vaccine. Hatchability was not adversely affected. When a high dose (10 times maximum commercial dose) of vaccine was tested in maternal antibody negative (MA-) eggs, mild clinical ...

journal_title：Vaccine

authors： Worthington KJ,Sargent BA,Davelaar FG,Jones RC

更新日期：2003-03-28 00:00:00

abstract：:Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity a...

journal_title：Vaccine

authors： Carrion R Jr,Patterson JL,Johnson C,Gonzales M,Moreira CR,Ticer A,Brasky K,Hubbard GB,Moshkoff D,Zapata J,Salvato MS,Lukashevich IS

更新日期：2007-05-16 00:00:00

abstract：:Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute encephalitis with high mortality in humans. To understand the virus-host interactions that influence JEV virulence, we determined the lethality of a neurovirulent (RP-9) and an attenuated (RP-2ms) variant of JEV in several immunodeficie...

journal_title：Vaccine

authors： Liang JJ,Liao CL,Liao JT,Lee YL,Lin YL

更新日期：2009-05-11 00:00:00

abstract：INTRODUCTION:Two types of Japanese encephalitis (JE) vaccines, inactivated JE vaccine (JE-I) and live-attenuated JE vaccine (JE-L), are available and used in China. In particular, one JE-L, produced by a domestic manufacturer in China, was prequalified by WHO in 2013. We assessed the safety of JE vaccines in China duri...

journal_title：Vaccine

authors： Wu W,Liu D,Li K,Nuorti JP,Nohynek HM,Xu D,Ye J,Zheng J,Wang H

更新日期：2017-06-22 00:00:00

abstract：:The growth of Mycobacterium w, a candidate strain for leprosy vaccine in submerged culture, was inhibited by the presence of over 40% oxygen saturation in the medium. Intracellular levels of superoxide dismutase and catalase were very low in the beginning. However, under controlled oxygenation, these levels increased ...

journal_title：Vaccine

authors： Mukhopadhyay A,Panda AK,Pandey AK

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:Meningococcal C conjugate vaccine was included in December 2000 in the Spanish childhood vaccination at 2, 4 and 6 months of age. In 2006, routine vaccination was modified to two doses at 2 and 4-6 months and a booster dose during the second year of age. Additionally, successive catch-up campaigns were launched...

journal_title：Vaccine

authors： Garrido-Estepa M,León-Gómez I,Herruzo R,Cano R

更新日期：2014-05-07 00:00:00

abstract：:We described here the characterization of Schistosoma mansoni egg antigens recognized by human monoclonal antibodies B10 (HmAb-B10) and D5 (HmAb-D5). SDS-PAGE and Western blot analysis revealed that these monoclonals recognized two antigens of M W 44.7/56.8 kDa, with pI of 7.0 and 7.8, respectively. The passive transf...

journal_title：Vaccine

authors： Hirsch C,Almeida CA,Doughty BL,Goes AM

更新日期：1997-06-01 00:00:00

abstract：:Group A Streptococcus (GAS) infections represent a major public health burden in both developing and developed countries. In Australia and New Zealand GAS associated diseases are serious problems in Indigenous populations and a major cause of health inequality. Political recognition of these inequalities is providing ...

journal_title：Vaccine

authors： Moreland NJ,Waddington CS,Williamson DA,Sriskandan S,Smeesters PR,Proft T,Steer AC,Walker MJ,Baker EN,Baker MG,Lennon D,Dunbar R,Carapetis J,Fraser JD

更新日期：2014-06-24 00:00:00

abstract：:This phase 1 clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from a lpxL2(-) synX(-) mutant of strain 44/76 with opcA expression stabilized. Thirty-four volunteers were assigned to one of the three dose groups (25 mcg, 25 mcg with aluminum hydroxide adju...

journal_title：Vaccine

authors： Keiser PB,Gibbs BT,Coster TS,Moran EE,Stoddard MB,Labrie JE 3rd,Schmiel DH,Pinto V,Chen P,Zollinger WD

更新日期：2010-10-08 00:00:00

abstract：:A gene encoding the mature Escherichia coli heat-labile enterotoxin B subunit (LTB) was introduced in a vector pNU212 and expressed at high levels in Bacillus brevis HPD31. The maximum amount of recombinant LTB (rLTB) secreted into the modified 5PY medium containing erythromycin was about 350 mg l(-1) when cultivated ...

journal_title：Vaccine

authors： Kozuka S,Yasuda Y,Isaka M,Masaki N,Taniguchi T,Matano K,Moriyama A,Ohkuma K,Goto N,Udaka S,Tochikubo K

更新日期：2000-03-06 00:00:00

abstract：:Human pythiosis is an emerging disease in the tropical, subtropical and temperate regions of the world. It is caused by the straminipilan, fungus-like, aquatic organism Pythium insidiosum. Pythiosis occurs in localized as well as systemic or vascular forms. Most patients with arterial pythiosis usually have underlying...

journal_title：Vaccine

authors： Wanachiwanawin W,Mendoza L,Visuthisakchai S,Mutsikapan P,Sathapatayavongs B,Chaiprasert A,Suwanagool P,Manuskiatti W,Ruangsetakit C,Ajello L

更新日期：2004-09-09 00:00:00

abstract：:T lymphocytes play a central role in the generation of a protective immune response in many microbial infections. After immunization, dendritic cells take up microbial antigens and traffic to draining lymph nodes where they present processed antigens to naïve T cells. These naïve T cells are stimulated to proliferate ...

journal_title：Vaccine

authors： Esser MT,Marchese RD,Kierstead LS,Tussey LG,Wang F,Chirmule N,Washabaugh MW

更新日期：2003-01-17 00:00:00

abstract：:The characterization of the cross-reactive, or heterologous, neutralizing antibody (NAb) responses developed during HIV-1-infection is relevant to the development of an HIV vaccine. Here we summarize our recently published study where we characterized the cross-reactive NAb responses in two cohorts of anti-retroviral ...

journal_title：Vaccine

authors： Sather DN,Stamatatos L

更新日期：2010-05-26 00:00:00