A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity.

abstract：:Since the development of the first vaccine over 200 years ago, vaccines have saved millions of lives and have become the most cost-effective modern medical intervention. However, over 70 years ago, Freund recognized that the effectiveness of the vaccine-induced immune responses could be vastly improved via the co-deli...

journal_title：Vaccine

authors： Alter G,Sekaly RP

更新日期：2015-06-08 00:00:00

abstract：:We assessed whether measles virus-specific antibody levels in the Dutch population as estimated by an enzyme-linked immunosorbent assay (ELISA) were comparable with estimates by virus neutralisation assay (NT), prompted by a relatively low ELISA seroprevalence in the 10-21-year-old group. We tested 791 sera from indiv...

journal_title：Vaccine

authors： van den Hof S,van Gageldonk-Lafeber AB,van Binnendijk RS,van Gageldonk PG,Berbers GA

更新日期：2003-10-01 00:00:00

abstract：:In 2003 Italy adopted the National Plan for Measles and Congenital Rubella Elimination, but some outbreaks of measles are still occurring, as the target coverage rate (≥ 95%) for new-borns has currently not been achieved. In order to support the monitoring of the measles elimination programme, the authors carried out ...

journal_title：Vaccine

authors： Tafuri S,Gallone MS,Gallone MF,Pappagallo MT,Larocca A,Germinario C

更新日期：2016-04-19 00:00:00

abstract：:We performed a randomized, controlled clinical trial to characterize the evolution of the adverse events associated with the fifth consecutive dose of an acellular pertussis vaccine, and to assess the level of discomfort associated with the injection and the attitude of parents concerning these events. A total of 505 ...

journal_title：Vaccine

authors： Halperin SA,Scheifele D,Mills E,Guasparini R,Humphreys G,Barreto L,Smith B

更新日期：2003-06-02 00:00:00

abstract：:Sulfated chitin derivatives, selected for their low toxicity and high inhibitory activity of melanoma metastasis, were examined for anti-viral activity against Friend murine leukaemia, herpes simplex type-1 (HSV) and Sendai viruses. Carboxymethyl chitin with a 7.66% degree of sulfation (SCM-chitin III) showed a signif...

journal_title：Vaccine

authors： Ishihara C,Yoshimatsu K,Tsuji M,Arikawa J,Saiki I,Tokura S,Azuma I

更新日期：1993-01-01 00:00:00

abstract：:Malignant catarrhal fever (MCF) is a fatal lymphoproliferative disease of cattle that, in East Africa, results from transmission of the causative virus, alcelaphine herpesvirus 1 (AlHV-1), from wildebeest. A vaccine field trial involving an attenuated AlHV-1 virus vaccine was performed over two wildebeest calving seas...

journal_title：Vaccine

authors： Lankester F,Russell GC,Lugelo A,Ndabigaye A,Mnyambwa N,Keyyu J,Kazwala R,Grant D,Percival A,Deane D,Haig DM,Cleaveland S

更新日期：2016-02-03 00:00:00

abstract：:Intranasal (i.n.) vaccination of mice with three doses of 40 microg of rRV stimulated low anti-ricin ELISA and neutralizing antibody responses, which were only marginally protective against aerosol-delivered 5-10 LD(50) of ricin toxin. To enhance the protection, and to reduce the lung injury of vaccinated mice that su...

journal_title：Vaccine

authors： Kende M,Tan X,Wlazlowski C,Williams R,Lindsey C,Del Giudice G

更新日期：2007-04-20 00:00:00

abstract：:Immunization protocols based on priming with plasmid DNA and boosting with recombinants of vaccinia virus (rVV) encoding the same antigen offer great promise for the prevention and treatment of many parasitic and viral infections for which conventional vaccination has little or no effect. To overcome some of the poten...

journal_title：Vaccine

authors： López-Fuertes L,Pérez-Jiménez E,Vila-Coro AJ,Sack F,Moreno S,Konig SA,Junghans C,Wittig B,Timón M,Esteban M

更新日期：2002-12-13 00:00:00

abstract：OBJECTIVE:Using qualitative methods, we explored the implementation of California's 2007 influenza immunization requirements of hospital-based health care personnel (HCP). METHODS:We conducted nine case studies of California hospitals with different HCP vaccination rates and policies. Case studies consisted of intervi...

journal_title：Vaccine

authors： Khodyakov D,Uscher-Pines L,Lorick SA,Lindley MC,Shier V,Harris K

更新日期：2014-05-23 00:00:00

abstract：:Here we demonstrated that bis-(3',5')-cyclic dimeric inosine monophosphate (c-di-IMP) exhibits potent adjuvant properties. BALB/c or C57BL/6 mice were immunized with the model antigens beta-galactosidase (beta-Gal) or Ovalbumin (OVA) alone or co-administered with c-di-IMP by the intranasal route. Animals receiving c-d...

journal_title：Vaccine

authors： Libanova R,Ebensen T,Schulze K,Bruhn D,Nörder M,Yevsa T,Morr M,Guzmán CA

更新日期：2010-03-02 00:00:00

abstract：:Gamma inulin and Algammulin, two new adjuvants, were examined and compared with alum and Freund's Complete/Incomplete Adjuvant (FCA/FIA), for potentiation of cell-mediated immunity (CMI) and humoral immunity in sheep to a recombinant Taenia ovis antigen. The ability to protect sheep when challenged with live T. ovis e...

journal_title：Vaccine

authors： Deol HS,Palmer DG,Dunsmore T,Carnegie PR

更新日期：1995-04-01 00:00:00

abstract：:The ELISA method was used to titrate the humoral immune response in vaccinated mice. When mice were given two doses of a heat-killed salmonella vaccine 6 days apart, there was a steady but low-level increase of antibody synthesis. In contrast, if a booster vaccination was administered 21 days after the primary inocula...

journal_title：Vaccine

authors： Xu HR,Hsu HS,Moncure CW,King RA

更新日期：1993-01-01 00:00:00

abstract：:Since the mid-1970s, the widespread establishment and implementation of the Expanded Programme on Immunization (EPI) has led to remarkable achievements in controlling vaccine preventable diseases worldwide. Today, more children than ever are being reached with immunization; interruption of poliomyelitis transmission h...

journal_title：Vaccine

authors： Okwo-Bele JM,Cherian T

更新日期：2011-12-30 00:00:00

abstract：:Delivery of antigens to antigen presenting cell surface receptors represents a promising strategy to improve immune response to weak immunogenic antigens. We have analyzed the potential of porcine sialoadhesin (Sn) and CD163 as antigen targeting receptors using mouse Igs as surrogate antigens. Sn and CD163 are two end...

journal_title：Vaccine

authors： Poderoso T,Martínez P,Álvarez B,Handler A,Moreno S,Alonso F,Ezquerra Á,Domínguez J,Revilla C

更新日期：2011-06-24 00:00:00

abstract：:A conjugate vaccine against meningococcus A and C was prepared using the non-toxic mutant of diphtheria toxin CRM 197 as a carrier protein. Capsular polysaccharides of Neisseria meningitidis group A and C were hydrolysed and the resulting oligosaccharides were then coupled to CRM 197 in order to obtain conjugates with...

journal_title：Vaccine

authors： Costantino P,Viti S,Podda A,Velmonte MA,Nencioni L,Rappuoli R

更新日期：1992-01-01 00:00:00

abstract：:The aim of current study was to evaluate the prospects of somatostatin DNA vaccine. Two copies of somatostatin (SS) genes were fused with the hepatitis B surface antigen (HBsAg) S gene using genetic engineering methods, the identified recombinant plasmid designated as pcS/2SS was transfected into HeLa cells to detect ...

journal_title：Vaccine

authors： Liang A,Cao S,Han L,Yao Y,Moaeen-Ud-Din M,Yang L

更新日期：2008-06-02 00:00:00

abstract：:Staphylococci have become the most common causes of nosocomial bacterial infections, and this fact, along with increasing problems associated with antimicrobial resistance, spurs the need for finding immunotherapeutic alternatives to prevent and possibly treat these infections. Most virulent, clinical isolates of both...

journal_title：Vaccine

authors： Maira-Litran T,Kropec A,Goldmann D,Pier GB

更新日期：2004-02-17 00:00:00

abstract：:The emergence of lineage 2 strains of WNV in Europe as a cause of clinical disease and mortality in horses raised the question whether the existing WNV vaccines, all based on lineage 1 strains, protect against circulating lineage 2 strains of WNV. In the present paper we have determined the level of cross protection p...

journal_title：Vaccine

authors： Minke JM,Siger L,Cupillard L,Powers B,Bakonyi T,Boyum S,Nowotny N,Bowen R

更新日期：2011-06-20 00:00:00

abstract：:DNA vaccination is particularly efficient for induction of cytotoxic T-lymphocyte (CTL) response. In our experiments, we used MHC(B) congenic chicken lines CB and CC (regressors and progressors of v-src-induced tumours, respectively) and a mutated, non-oncogenic v-src gene construct as the DNA vaccine. A high degree o...

journal_title：Vaccine

authors： Plachý JV,Hejnar JV,Trtková K,Trejbalová K,Svoboda J,Hála K

更新日期：2001-08-14 00:00:00

abstract：:The aim of this study was to determine the rubella seroprevalence in women of reproductive age. This cross-sectional study was conducted on women aged 15-49 years. Serologic studies were performed by using the ELISA method. The number of women enrolled in the study was 607, the mean age was 30.7+/-9.3 years and 13.2% ...

journal_title：Vaccine

authors： Sasmaz T,Kurt AO,Ozturk C,Bugdayci R,Oner S

更新日期：2007-01-15 00:00:00

abstract：:Seasonal influenza vaccines represent a positive intervention to limit the spread of the virus and protect public health. Yet continual influenza evolution and its ability to evade immunity pose a constant threat. For these reasons, vaccines with improved potency and breadth of protection remain an important need. We ...

journal_title：Vaccine

authors： Rudicell RS,Garinot M,Kanekiyo M,Kamp HD,Swanson K,Chou TH,Dai S,Bedel O,Simard D,Gillespie RA,Yang K,Reardon M,Avila LZ,Besev M,Dhal PK,Dharanipragada R,Zheng L,Duan X,Dinapoli J,Vogel TU,Kleanthous H,Mascola J

更新日期：2019-09-30 00:00:00

abstract：BACKGROUND:In 2017, measles elimination was verified in Bhutan, and the country appears to have sufficiently high vaccination coverage to achieve rubella elimination. However, a measles and rubella serosurvey was conducted to find if any hidden immunity gaps existed that could threaten Bhutan's elimination status. MET...

journal_title：Vaccine

authors： Wangchuk S,Nogareda F,Tshering N,Khandu L,Pelden S,Wannemuehler K,Wangdi S,Wangchuk U,Mulders M,Tamang T,Patel MK

更新日期：2019-10-08 00:00:00

abstract：:Targeting immune checkpoint receptors has emerged as an effective strategy to induce immune-mediated cancer regression in the subset of patients who have significant pre-existing anti-tumor immunity. For the remainder, effective anti tumor responses may require vaccination. Radiotherapy, traditionally used to achieve ...

journal_title：Vaccine

authors： Vanpouille-Box C,Pilones KA,Wennerberg E,Formenti SC,Demaria S

更新日期：2015-12-16 00:00:00

abstract：:The human immune defense system is composed of two distinct elements: innate immunity located primarily at body surfaces restricted by species-specific CD1 molecules and acquired immunity found mainly in internal compartments associated with individually restricted MHC molecules. Historically, effective vaccines have ...

journal_title：Vaccine

authors： Takahashi H

更新日期：2010-05-26 00:00:00

abstract：:Measles incidence has decreased dramatically in China due to the implement of measles-containing vaccine (MCV). However, a measles epidemic caused resurgence recently, even among vaccinated individuals. To evaluate the effectiveness of current immunization programs and discuss initiatives for the next step in measles ...

journal_title：Vaccine

authors： Cui A,Zhang Y,Zhu Z,Wang H,Mao N,Song J,Xu W

更新日期：2020-05-08 00:00:00

abstract：:In clinical trials recombinant-modified vaccinia virus Ankara expressing the Mycobacterium tuberculosis antigen 85A (MVA85A) induces approximately 10 times more effector T cells than any other recombinant MVA vaccine. We have found that in BCG primed subjects MVA85A vaccination reduces transforming growth factor beta ...

journal_title：Vaccine

authors： Fletcher HA,Pathan AA,Berthoud TK,Dunachie SJ,Whelan KT,Alder NC,Sander CR,Hill AV,McShane H

更新日期：2008-09-26 00:00:00

abstract：:Applicability of the endotoxin test to diphtheria-tetanus-acellular pertussis combined (DTaP) vaccines was examined. We found some DTaP vaccines that strongly interfered with Limulus amoebocyte lysate (LAL) activity of endotoxin without affecting lethal activity of endotoxin in D-galactosamine-treated mice. LAL activi...

journal_title：Vaccine

authors： Ochiai M,Kataoka M,Toyoizumi H,Kamachi K,Yamamoto A,Horiuchi Y

更新日期：2003-05-16 00:00:00

abstract：:The identification of new vaccine candidates for leptospirosis is of great interest. This paper describes the identification of two homologous immunogenic proteins, LigA-m and LigB-m, of Leptospira interrogans serovar manilae strain UP-MMC-NIID, which show strong similarity with LigA found recently in L. interrogans s...

journal_title：Vaccine

authors： Koizumi N,Watanabe H

更新日期：2004-03-29 00:00:00

abstract：:Herpes simplex virus (HSV) infections are common but there is no vaccine available. We evaluated cationic liposome-DNA complexes (CLDC) as an adjuvant for an HSV gD2 vaccine and compared it to an MPL/Alum adjuvant in a guinea pig model of genital herpes. The addition of CLDC to the gD2 vaccine significantly decreased ...

journal_title：Vaccine

authors： Bernstein DI,Farley N,Bravo FJ,Earwood J,McNeal M,Fairman J,Cardin R

更新日期：2010-05-07 00:00:00

abstract：:One of the greatest challenges to HCV vaccine development is the induction of effective immune responses using recombinant proteins or vectors. In order to better understand which vaccine-induced antibodies contribute to neutralization of HCV the quality of polyclonal anti-E1E2 antibody responses in immunized mice and...

journal_title：Vaccine

authors： Kachko A,Kochneva G,Sivolobova G,Grazhdantseva A,Lupan T,Zubkova I,Wells F,Merchlinsky M,Williams O,Watanabe H,Ivanova A,Shvalov A,Loktev V,Netesov S,Major ME

更新日期：2011-12-09 00:00:00