Abstract：
:In clinical trials recombinant-modified vaccinia virus Ankara expressing the Mycobacterium tuberculosis antigen 85A (MVA85A) induces approximately 10 times more effector T cells than any other recombinant MVA vaccine. We have found that in BCG primed subjects MVA85A vaccination reduces transforming growth factor beta 1 (TGF-beta1) mRNA in peripheral blood lymphocytes and reduces TGF-beta1 protein in the serum, but increases IFN-gamma ELISPOT responses to the recall antigen SK/SD. TGF-beta1 is essential for the generation of regulatory T cells and we see a correlation across vaccinees between CD4+CD25hiFoxP3+ cells and TGF-beta1 serum levels. This apparent ability to counteract regulatory T cell effects suggests a potential use of MVA85A as an adjuvant for less immunogenic vaccines.
journal_name
Vaccinejournal_title
Vaccineauthors
Fletcher HA,Pathan AA,Berthoud TK,Dunachie SJ,Whelan KT,Alder NC,Sander CR,Hill AV,McShane Hdoi
10.1016/j.vaccine.2008.07.040subject
Has Abstractpub_date
2008-09-26 00:00:00pages
5269-75issue
41eissn
0264-410Xissn
1873-2518pii
S0264-410X(08)00984-5journal_volume
26pub_type
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