Leprosy vaccine: influence of dissolved oxygen levels on growth of a candidate strain (Mycobacterium w), and storage stability of the vaccine.

abstract：:Lassa virus (LASV) causes a severe hemorrhagic fever endemic throughout western Africa. Because of the ability to cause lethal disease in humans, limited treatment options, and potential as a bioweapon, the need for vaccines to prevent LASV epidemic is urgent. However, LASV vaccine development has been hindered by the...

journal_title：Vaccine

authors： Li Q,Liu Q,Huang W,Wu J,Nie J,Wang M,Zhao C,Zhang L,Wang Y

更新日期：2017-09-12 00:00:00

abstract：:In order to evaluate the long-term immunity 2 and 3 years after booster vaccination against tick-borne encephalitis (TBE) following time intervals 3 years and longer since last TBE immunization, 195 (mean age 50.5+/-15.1 years) and 240 subjects (mean age 47.0+/-15.4 years), respectively, who had received a single boos...

journal_title：Vaccine

authors： Rendi-Wagner P,Paulke-Korinek M,Kundi M,Wiedermann U,Laaber B,Kollaritsch H

更新日期：2007-06-28 00:00:00

abstract：:A carcinoembryonic antigen (CEA)-based DNA vaccine, adsorbed onto cationic microparticles of poly(DL-lactide-co-glycolide) (PLG) induced tumor-protective immunity against a lethal challenge of MC38-CEA colon carcinoma cells in CEA-transgenic mice that was more potent than that of the corresponding naked DNA vaccine. B...

journal_title：Vaccine

authors： Luo Y,O'Hagan D,Zhou H,Singh M,Ulmer J,Reisfeld RA,James Primus F,Xiang R

更新日期：2003-05-16 00:00:00

abstract：:Two modified live attenuated vaccines against the disease Rift Valley fever (RVF) have been tested for safety and efficacy in young calves. The RVF Smithburn vaccine produced in South Africa and used successfully to prevent and control the disease in endemic sub-Saharan countries was compared to the candidate vaccine ...

journal_title：Vaccine

authors： von Teichman B,Engelbrecht A,Zulu G,Dungu B,Pardini A,Bouloy M

更新日期：2011-08-05 00:00:00

abstract：:The availability of an inactivated hepatitis A virus (HAV) vaccine, and the development of live attenuated virus vaccines against hepatitis represent great advances in the effort to control an important cause of viral hepatitis. There are a number of ways hepatitis A vaccines could be used, depending on the epidemiolo...

journal_title：Vaccine

authors： Kane MA

更新日期：1992-01-01 00:00:00

abstract：:Group A meningococcal disease is epidemic in Sudan, less common in Uganda, a country bordering the "meningitis belt," and rare in North America. The basis of naturally-acquired group A immunity is unknown but in North America protection has been attributed to a high prevalence of serum anticapsular antibodies elicited...

journal_title：Vaccine

authors： Amir J,Louie L,Granoff DM

更新日期：2005-01-11 00:00:00

abstract：:Smallpox eradication, coordinated by the WHO and certified 40 years ago, led to the cessation of routine smallpox vaccination in most countries. It is estimated that over 70% of the world's population is no longer protected against smallpox, and through cross-immunity, to closely related orthopox viruses such as monke...

journal_title：Vaccine

authors： Simpson K,Heymann D,Brown CS,Edmunds WJ,Elsgaard J,Fine P,Hochrein H,Hoff NA,Green A,Ihekweazu C,Jones TC,Lule S,Maclennan J,McCollum A,Mühlemann B,Nightingale E,Ogoina D,Ogunleye A,Petersen B,Powell J,Quantick O

更新日期：2020-07-14 00:00:00

abstract：OBJECTIVE:Using qualitative methods, we explored the implementation of California's 2007 influenza immunization requirements of hospital-based health care personnel (HCP). METHODS:We conducted nine case studies of California hospitals with different HCP vaccination rates and policies. Case studies consisted of intervi...

journal_title：Vaccine

authors： Khodyakov D,Uscher-Pines L,Lorick SA,Lindley MC,Shier V,Harris K

更新日期：2014-05-23 00:00:00

abstract：:To assess the reactogenicity and immunogenicity of the Biken acellular pertussis vaccine (Pa) following administration of a single vaccine dose to young adults with or without a history of prior pertussis immunization, 104 healthy, male and female adults without primary pertussis immunization were enrolled in Mainz (f...

journal_title：Vaccine

authors： Schmitt HJ,Mohnike K,Zepp F,Herden P,Hosbach P

更新日期：2000-10-15 00:00:00

abstract：:Two rotavirus vaccines have been available since 2006. This study evaluates the effectiveness of these vaccines using a test-negative case-control design in Navarre, Spain. We included children 3-59 months of age who sought medical care for gastroenteritis and for whom stool samples were taken between January 2008 and...

journal_title：Vaccine

authors： Castilla J,Beristain X,Martínez-Artola V,Navascués A,García Cenoz M,Alvarez N,Polo I,Mazón A,Gil-Setas A,Barricarte A

更新日期：2012-01-11 00:00:00

abstract：:We assessed whether measles virus-specific antibody levels in the Dutch population as estimated by an enzyme-linked immunosorbent assay (ELISA) were comparable with estimates by virus neutralisation assay (NT), prompted by a relatively low ELISA seroprevalence in the 10-21-year-old group. We tested 791 sera from indiv...

journal_title：Vaccine

authors： van den Hof S,van Gageldonk-Lafeber AB,van Binnendijk RS,van Gageldonk PG,Berbers GA

更新日期：2003-10-01 00:00:00

abstract：:This study investigated predictors of influenza vaccination uptake since the introduction of the policy to target over 65s. Four hundred and forty-four participants completed a cross-sectional structured interview. The predictors of vaccination uptake were: having a doctor or nurse who explained why the vaccination is...

journal_title：Vaccine

authors： Burns VE,Ring C,Carroll D

更新日期：2005-05-20 00:00:00

abstract：:Immunization with Mycobacterium bovis Bacille Calmette-Guerin (BCG) did not induce adequate Th1 responses to the latency antigen, HspX of M. tuberculosis. To increase the immunogenicity and protective efficacy of BCG, a recombinant BCG strain over-expressing antigen HspX (rBCG::X) was constructed. The recombinant stra...

journal_title：Vaccine

authors： Shi C,Chen L,Chen Z,Zhang Y,Zhou Z,Lu J,Fu R,Wang C,Fang Z,Fan X

更新日期：2010-07-19 00:00:00

abstract：:New and improved vaccines and delivery systems are increasingly being developed for prevention, treatment and diagnosis of human diseases. Prior to their use in humans, all new biological products must undergo pre-clinical evaluation. These pre-clinical studies are important not only to establish the biological proper...

journal_title：Vaccine

authors： Sesardic D

更新日期：2006-04-12 00:00:00

abstract：:The incidence of Lyme disease has continued to rise despite attempts to control its spread. Vaccination of zoonotic reservoirs of human pathogens has been successfully used to decrease the incidence of rabies in raccoons and foxes. We have previously reported on the efficacy of a vaccinia virus vectored vaccine to red...

journal_title：Vaccine

authors： Kern A,Zhou CW,Jia F,Xu Q,Hu LT

更新日期：2016-08-31 00:00:00

abstract：:Mutations arising in neutralizing epitopes of hepatitis C virus may play a role in the ability of the virus to escape control by neutralizing antibodies and in the establishment of chronic infections. An amino-acid substitution, Q412H, within a major conserved neutralization epitope EP I (aa 412-426) in the E2 glycopr...

journal_title：Vaccine

authors： Duan H,Struble E,Zhong L,Mihalik K,Major M,Zhang P,Feinstone S,Feigelstock D

更新日期：2010-06-07 00:00:00

abstract：:The protective effect of purified human immunoglobulin against human T-cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infection was examined in cynomolgus monkeys (Macaca fascicularis) as a preclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV...

journal_title：Vaccine

authors： Akari H,Suzuki T,Ikeda K,Hoshino H,Tomono T,Murotsuka T,Terao K,Ito H,Yoshikawa Y

更新日期：1997-08-01 00:00:00

abstract：:Native porcine zona pellucida (PZP) has been shown to be highly effective as an immunocontraceptive in white-tailed deer. However, the immunogenicity of PZP extracted from pig ovaries may vary from lot to lot and the extract has the potential of containing either viral or pathogenic material. Determination of the immu...

journal_title：Vaccine

authors： Miller LA,Killian GJ

更新日期：2002-06-21 00:00:00

abstract：:DNA vectors can be used to deliver vaccine antigens that stimulate effective protective immunity in mice, but in larger, outbred animal species, the protective efficacy is lower or large doses of DNA are required. These data demonstrate that porcine interleukin-3 (IL-3) when delivered to pigs by DNA vector or in low d...

journal_title：Vaccine

authors： Andrew M,Morris K,Coupar B,Sproat K,Oke P,Bruce M,Broadway M,Morrissy C,Strom D

更新日期：2006-04-12 00:00:00

abstract：:To evaluate the immunogenicity of 23-valent pneumococcal polysaccharide vaccine in 52 nursing homes residents aged > or = 60 years, IgG antibodies to serotypes 1, 5, 6B, and 8 were measured by ELISA and compared before, and 1 and 12 months following vaccination. A significant immunological response for all serotypes w...

journal_title：Vaccine

authors： Brandão AP,de Oliveira TC,de Cunto Brandileone MC,Gonçalves JE,Yara TI,Simonsen V

更新日期：2004-12-21 00:00:00

abstract：:The purpose of the NIAID/FDA joint workshop, "correlates of immunity for pneumococcal conjugate vaccines (PCVs)," was to discuss the present understanding of protective immunity against invasive pneumococcal disease and identify in vitro measures that may represent immunologic correlates in future clinical trials. Ani...

journal_title：Vaccine

authors： Lee LH,Frasch CE,Falk LA,Klein DL,Deal CD

更新日期：2003-05-16 00:00:00

abstract：:On 16-17 November 2011, the Initiative for Vaccine Research of the World Health Organization convened jointly with the Wellcome Trust the fifth meeting on 'Influenza vaccines that induce broad spectrum and long-lasting immune responses'. The goals of the meeting were to examine new influenza vaccine research developme...

journal_title：Vaccine

authors： Hughes B,Hayden F,Perikov Y,Hombach J,Tam JS

更新日期：2012-10-19 00:00:00

abstract：:The immunopotentiating activities of colloidal iron hydroxide, a novel, experimental mineral adjuvant, and of aluminium hydroxide. the licensed adjuvant for human vaccines, were compared. Our studies revealed that colloidal iron hydroxide and aluminium hydroxide behaved comparably with respect to supporting induction ...

journal_title：Vaccine

authors： Leibl H,Tomasits R,Brühl P,Kerschbaum A,Eibl MM,Mannhalter JW

更新日期：1999-03-05 00:00:00

abstract：:The 9th African rotavirus symposium was held in Maputo, Mozambique from the 8th to 10th of December 2015, including a total of 101 delegates from 17 countries, 15 of which were African countries. This forum brought together participants with various expertise including scientists, clinicians, immunization program mana...

journal_title：Vaccine

authors： Mandomando I,Weldegebriel G,de Deus N,Mwenda JM

更新日期：2017-03-23 00:00:00

abstract：:Plasmid DNA vaccines encoding full-length antigen often induce both potent antibody and cytotoxic T lymphocyte (CTL) responses. Here, we examine strategies to exclusively elicit epitope-specific CTL responses using DNA constructs expressing a minimal class I MHC-restricted epitope of the nucleoprotein (NP) of influenz...

journal_title：Vaccine

authors： Iwasaki A,Dela Cruz CS,Young AR,Barber BH

更新日期：1999-04-09 00:00:00

abstract：INTRODUCTION:Replication-competent vaccinia viruses (VACVs) show prolonged antigen expression time and greater stimulation of immune responses than their replication-incompetent counterparts. However, there is the potential risk of serious post-vaccination complications, especially for children and immunocompromised in...

journal_title：Vaccine

authors： Zhang Q,Liu Z,Hou J,Wang S,Liu C,Wei M,Liu Y,Shao Y

更新日期：2016-06-24 00:00:00

abstract：BACKGROUND:Since 2006, two rotavirus vaccines have been licensed in Taiwan, either as a 2- (RV1) or 3-dose (RV5) schedule administered at ages 2, 4, and 6 months. This study assessed the risk of intussusception and Kawasaki disease (KD) associated with rotavirus vaccines among infants. METHODS:Cases of intussusception...

journal_title：Vaccine

authors： Huang WT,Juan YC,Liu CH,Yang YY,Chan KA

更新日期：2020-09-11 00:00:00

abstract：:Accidental freezing of vaccines is a growing threat and a real risk for national immunization programs when the potency of many vaccines can be compromised if these are exposed to sub-zero temperatures in the cold chain. In Tunisia, this issue is compounded by using sub-standard domestic cold chain equipment instead o...

journal_title：Vaccine

authors： Lloyd J,Lydon P,Ouhichi R,Zaffran M

更新日期：2015-02-11 00:00:00

abstract：:Epidemic influenza occurs annually throughout the world and is accompanied by excess morbidity and mortality. Increasing the antigen content and topical administration of vaccine are two strategies being explored to improve the immune responses to trivalent inactivated influenza vaccine (TIV). We conducted a randomize...

journal_title：Vaccine

authors： Atmar RL,Keitel WA,Cate TR,Munoz FM,Ruben F,Couch RB

更新日期：2007-07-20 00:00:00

abstract：INTRODUCTION:Widespread introduction of pneumococcal conjugated vaccines (PCVs) impacted on invasive pneumococcal disease (IPD). However, IPD reduction may not be similar in all outcomes within IPD. We assessed PCV7/PCV13 impact on pneumococcal meningitis, bacteremic pneumonia (BP) and other (non-meningitis, non-pneumo...

journal_title：Vaccine

authors： Ben-Shimol S,Givon-Lavi N,Grisaru-Soen G,Megged O,Greenberg D,Dagan R,Israel Bacteremia and Meningitis Active Surveillance Group.

更新日期：2018-08-28 00:00:00