当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice.

Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice.

Abstract：

:A carcinoembryonic antigen (CEA)-based DNA vaccine, adsorbed onto cationic microparticles of poly(DL-lactide-co-glycolide) (PLG) induced tumor-protective immunity against a lethal challenge of MC38-CEA colon carcinoma cells in CEA-transgenic mice that was more potent than that of the corresponding naked DNA vaccine. Boosting with a plasmid encoding murine GM-CSF increased the vaccine's efficacy leading to a complete rejection of tumor cells in 50% of mice. This effect was due to activation of MHC class I-restricted CD8(+) T cells coupled with an increased secretion of proinflammatory cytokines IFN-gamma, TNF-alpha and IL-2. Also, specific activation of dendritic cells was indicated by a two-three-fold upregulation of their costimulatory CD80 and MHC class II molecules. This approach may be a promising new strategy for the rational design of cancer vaccines for future clinical applications.

journal_name

Vaccine

journal_title

Vaccine

authors

Luo Y,O'Hagan D,Zhou H,Singh M,Ulmer J,Reisfeld RA,James Primus F,Xiang R

doi

10.1016/s0264-410x(02)00821-6

subject

Has Abstract

pub_date

2003-05-16 00:00:00

pages

1938-47

issue

17-18

eissn

0264-410X

issn

1873-2518

pii

S0264410X02008216

journal_volume

21

pub_type

杂志文章

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