Abstract:
:To evaluate the immunogenicity of 23-valent pneumococcal polysaccharide vaccine in 52 nursing homes residents aged > or = 60 years, IgG antibodies to serotypes 1, 5, 6B, and 8 were measured by ELISA and compared before, and 1 and 12 months following vaccination. A significant immunological response for all serotypes was observed at 1 month after vaccination. The mean increase in antibody concentration was highly variable and ranged from 1.6 to 2.7. After 1 year, the mean concentrations remained significantly higher than prior to vaccination for serotypes 1, 6B, and 8, although there was a decrease in all mean IgG concentrations. Antibody levels were higher in men than in women, before and after immunisation. Post-vaccination values tended to be lower among subjects aged >75 years. Reduction in IgG concentrations by 33% 1 year after vaccination suggests that revaccination of institutionalised elderly people may be needed.
journal_name
Vaccinejournal_title
Vaccineauthors
Brandão AP,de Oliveira TC,de Cunto Brandileone MC,Gonçalves JE,Yara TI,Simonsen Vdoi
10.1016/j.vaccine.2004.07.024subject
Has Abstractpub_date
2004-12-21 00:00:00pages
762-8issue
6eissn
0264-410Xissn
1873-2518pii
S0264-410X(04)00548-1journal_volume
23pub_type
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