当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Immunogenicity, reactogenicity and persistence of meningococcal A, C, W-135 and Y-tetanus toxoid candidate conjugate (MenACWY-TT) vaccine formulations in adolescents aged 15-25 years.

Immunogenicity, reactogenicity and persistence of meningococcal A, C, W-135 and Y-tetanus toxoid candidate conjugate (MenACWY-TT) vaccine formulations in adolescents aged 15-25 years.

Abstract：

:Development of meningococcal serogroups A, C, W-135 and Y conjugate vaccines could expand coverage against devastating meningococcal diseases. The immunogenicity of one dose of each one of five MenACWY-TT formulations versus a licensed ACWY polysaccharide vaccine was evaluated in 175 healthy subjects of 15-25 years. Serum bactericidal titers (rSBA) were evaluated before and after vaccination. The percentage of rSBA responders to each serogroup A, C, W-135 and Y did not statistically differ from the control for each of the five formulations except for serogroup A that was lower after administration of one formulation. In the 3-year follow-up of the first study where the latter formulation was assessed, bactericidal antibody persistence was similar to the licensed ACWY polysaccharide vaccine for MenA and MenC and higher for MenW-135 and MenY. Our results present five investigational MenACWY-TT conjugate vaccine formulations which are well tolerated and highly immunogenic in adolescents.

journal_name

Vaccine

journal_title

Vaccine

authors

Ostergaard L,Lebacq E,Poolman J,Maechler G,Boutriau D

doi

10.1016/j.vaccine.2008.08.075

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

161-8

issue

1

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)01191-2

journal_volume

27

pub_type

杂志文章,随机对照试验

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