Abstract：
:Group A Streptococcus (GAS) infections represent a major public health burden in both developing and developed countries. In Australia and New Zealand GAS associated diseases are serious problems in Indigenous populations and a major cause of health inequality. Political recognition of these inequalities is providing impetus for strategies that reduce GAS disease and the development of a GAS vaccine now has governmental support in both Australia and New Zealand. Accordingly, an expert workshop was convened in March 2013 to consider available data on GAS vaccines. M-protein based vaccines constructed from the hyper-variable N-terminal region (30-valent vaccine) or the conserved C-repeat domain (J8 vaccine) were reviewed together with vaccine candidates identified using multi high-throughput approaches. Performing a comprehensive assessment of regional GAS strain epidemiology, defining the immune correlates of protection, and the establishment of clinical trial sites were identified as critical activities for a Trans-Tasman vaccine development programme.
journal_name
Vaccinejournal_title
Vaccineauthors
Moreland NJ,Waddington CS,Williamson DA,Sriskandan S,Smeesters PR,Proft T,Steer AC,Walker MJ,Baker EN,Baker MG,Lennon D,Dunbar R,Carapetis J,Fraser JDdoi
10.1016/j.vaccine.2014.05.017subject
Has Abstractpub_date
2014-06-24 00:00:00pages
3713-20issue
30eissn
0264-410Xissn
1873-2518pii
S0264-410X(14)00673-2journal_volume
32pub_type
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