Abstract：
:This randomized, double-blind trial conducted in the US and Canada was conducted to compare the safety and immunogenicity of two dosages of live attenuated oral monovalent G1 human rotavirus (HRV) vaccine administered orally at a 2-month interval concomitantly with routine childhood vaccines to healthy infants 5-15 weeks of age. No SAEs considered related to vaccine were reported. The incidence of solicited symptoms was similar among treatment groups during the 15-day post-vaccination surveillance periods. No significant difference in vaccine take after 2 doses (88.0% in high dose group and 81.5% in low dose group) was seen between vaccine groups. Two doses of either dosage level of HRV vaccine administered concurrently with routine childhood vaccines to healthy infants were well tolerated and elicited excellent vaccine takes.
journal_name
Vaccinejournal_title
Vaccineauthors
Dennehy PH,North American Human Rotavirus Vaccine Study Group.doi
10.1016/j.vaccine.2005.07.030subject
Has Abstractpub_date
2006-05-01 00:00:00pages
3780-1issue
18eissn
0264-410Xissn
1873-2518pii
S0264-410X(05)00672-9journal_volume
24pub_type
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