Fluorescence spectroscopy monitoring of the conformational restraint of formaldehyde- and glutaraldehyde-treated infectious bursal disease virus proteins.

abstract：:The level of protection conferred by foot-and-mouth disease (FMD) vaccines in primovaccinated animals primarily depends on the potency of the vaccine and the relatedness of the vaccine strain and circulating field isolate. The "Gold Standard" FMD vaccine potency test is the in vivo test performed in the target species...

journal_title：Vaccine

authors： Goris N,Maradei E,D'Aloia R,Fondevila N,Mattion N,Perez A,Smitsaart E,Nauwynck HJ,La Torre J,Palma E,De Clercq K

更新日期：2008-06-25 00:00:00

abstract：:The worldwide HIV-1 vaccine research endeavor is focused increasingly on subtype C, which is now the predominant strain of the present HIV/AIDS epidemic. Expression cassettes of HIV-1 subtype C gag, pol and versions of gagpol fusion cassettes were constructed and evaluated for their relative abilities to induce cellul...

journal_title：Vaccine

authors： Megede JZ,Otten GR,Doe B,Liu H,Srivastava R,Greer C,Legg H,Tang T,Polo JM,Donnelly JJ,Ulmer JB,Barnett SW

更新日期：2006-04-05 00:00:00

abstract：:We report on 30 in-depth mental models interviews with parents discussing vaccination for their children, both in general terms and in response to communications drawn from sources supporting and opposing vaccines. We found that even parents favourable to vaccination can be confused by the ongoing debate, leading them...

journal_title：Vaccine

authors： Downs JS,de Bruin WB,Fischhoff B

更新日期：2008-03-17 00:00:00

abstract：:In the face of an almost unprecedented threat of a global pandemic of influenza it is imperative that stockpiling of appropriate drugs and devices begin now. One vital device is an appropriate syringe for delivering vaccine. With the potential for millions to be infected and the vaccine supply severely stretched it is...

journal_title：Vaccine

authors： Strauss K,van Zundert A,Frid A,Costigliola V

更新日期：2006-05-29 00:00:00

abstract：:In this study we have investigated the immunogenicity and antigenicity of synthetic immunocontraceptive vaccine candidates containing T- and B-cell epitopes arranged in different geometries. Two epitopes were selected, a B-cell epitope from fox sperm lactate dehydrogenase C(4) and a B-cell epitope from murine zona pel...

journal_title：Vaccine

authors： Sadler K,Bird PH,Brown LE,Jackson DC

更新日期：1999-10-14 00:00:00

abstract：:To circumvent limitations of poor antigen presentation and immunogenicity of DNA vaccines that target induction of CD8(+) T cell immunity, we have generated single chain MHC I trimers (MHC I SCTs) composed of a single polypeptide chain with a linear composition of antigenic peptide, β2-microglobulin, and heavy chain o...

journal_title：Vaccine

authors： Kim S,Zuiani A,Carrero JA,Hansen TH

更新日期：2012-03-09 00:00:00

abstract：BACKGROUND:This phase I trial evaluated the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime-MVA85A boost, previously demonstrated to be protective in animal studies, in healthy UK adults. METHODS:We enrolled 42 healthy, BCG-vaccinated adults into 4 groups: low dose Starter ...

journal_title：Vaccine

authors： Wilkie M,Satti I,Minhinnick A,Harris S,Riste M,Ramon RL,Sheehan S,Thomas ZM,Wright D,Stockdale L,Hamidi A,O'Shea MK,Dwivedi K,Behrens HM,Davenne T,Morton J,Vermaak S,Lawrie A,Moss P,McShane H

更新日期：2020-01-22 00:00:00

abstract：:Neisseria meningitidis can cause severe and fulminant diseases such as meningitis. Meningococcal capsular polysaccharide (PS) is a key virulence determinant that is not able to induce immunological memory. Conjugation of PS to a carrier protein can significantly increase the immunogenicity of PS and induce immunologic...

journal_title：Vaccine

authors： Zhang T,Yu W,Wang Y,Hu T

更新日期：2015-06-22 00:00:00

abstract：:Due to viral strains, influenza season, and consultations and admission rates varying from country to country, the continued economic evaluation of influenza vaccination for the elderly people aged 65 years and above is paramount, particularly in areas with dense population. Efficacy and cost-effective analysis of inf...

journal_title：Vaccine

authors： Wang ST,Lee LT,Chen LS,Chen TH

更新日期：2005-03-14 00:00:00

abstract：:To inform World Health Organization recommendations regarding use of Haemophilus influenzae type b (Hib) vaccines in national immunization programs, a multi-country evaluation of trends in Hib meningitis incidence and prevalence of nasopharyngeal Hib carriage was conducted in four South American countries using either...

journal_title：Vaccine

authors： Garcia S,Lagos R,Muñoz A,Picón T,Rosa R,Alfonso A,Abriata G,Gentile A,Romanin V,Regueira M,Chiavetta L,Agudelo CI,Castañeda E,De la Hoz F,Higuera AB,Arce P,Cohen AL,Verani J,Zuber P,Gabastou JM,Pastor D,Flannery

更新日期：2012-01-05 00:00:00

abstract：:We tested the hypothesis that removal of viral lipids using diisopropylether can enhance antigenicity of SIVmac251. DIPE delipidation removed cholesterol from SIVmac251 without significant loss of viral protein or RNA. Mice immunized with the same SIV preparation but boosted with delipidated SIVmac251 exhibited signif...

journal_title：Vaccine

authors： Kitabwalla M,Villinger F,Akeefe H,Liao Z,Mayne AE,Gargano L,Conner AP,Maltais JA,Kunas G,Hildreth JE,Ansari AA,Bellotti M

更新日期：2005-09-07 00:00:00

abstract：:An ELISA-immunocapture assay was developed for quantification of influenza neuraminidases (N2 and B), with a sensitivity about 10 ng neuramidase(NA)/ml. This sensitive and specific assay was applied to several trivalent vaccine preparations (1997/1998 and 1998/1999). It was shown capable to detect 3.5-6.9 microg NA/ml...

journal_title：Vaccine

authors： Aymard M

更新日期：2002-05-15 00:00:00

abstract：:Vaccines have drastically reduced the mortality and morbidity of many diseases. However, vaccines have historically been developed empirically, and recent development of vaccines against current pandemics such as HIV and malaria has been met with difficulty. The advent of high-throughput technologies, coupled with sys...

journal_title：Vaccine

authors： Hagan T,Nakaya HI,Subramaniam S,Pulendran B

更新日期：2015-09-29 00:00:00

abstract：:Flagellin of Pseudomonas aeruginosa is an important vaccine candidate. N-terminal domains are highly conserved in both type a and type b flagellins. The efficacy of gold nanoparticles (AuNPs) conjugated to N-terminal domains of P. aeruginosa flagellin (flagellin(1-161)), as an immunogen in mice, has been assessed. The...

journal_title：Vaccine

authors： Dakterzada F,Mohabati Mobarez A,Habibi Roudkenar M,Mohsenifar A

更新日期：2016-03-14 00:00:00

abstract：:Langmuir adsorption isotherms of endotoxin and aluminum-containing adjuvants at pH 7.4 and 25 degrees C revealed that aluminum hydroxide adjuvant has a greater adsorption capacity (283 microg/mg Al) and adsorption coefficient (1.3x10(4) ml/miccrog) than aluminum phosphate adjuvant (3.0 microg/mg Al, 0.20 ml/microg). T...

journal_title：Vaccine

authors： Shi Y,HogenEsch H,Regnier FE,Hem SL

更新日期：2001-02-08 00:00:00

abstract：BACKGROUND:Invasive meningococcal disease (IMD) is a major cause of bacterial meningitis and septicaemia although infection by some serogroups may be prevented through vaccination. We aimed to describe the epidemiology of IMD in EU/EEA countries during 2004-2014 to monitor serogroup- and age-specific trends, and compar...

journal_title：Vaccine

authors： Whittaker R,Dias JG,Ramliden M,Ködmön C,Economopoulou A,Beer N,Pastore Celentano L,ECDC network members for invasive meningococcal disease.

更新日期：2017-04-11 00:00:00

abstract：:Coli surface antigen 6, CS6, is one of the most prevalent colonization factors (CFs) associated with Enterotoxigenic Escherichia coli (ETEC) bacteria, the most common cause of diarrhea among infants and children in developing countries. The CS6 operon encodes two structural subunit proteins, CssA and CssB, a chaperon,...

journal_title：Vaccine

authors： Tobias J,Lebens M,Källgård S,Nicklasson M,Svennerholm AM

更新日期：2008-10-03 00:00:00

abstract：OBJECTIVES:To assess immunogenicity and safety of the 23-valent polysaccharide pneumococcal vaccine (PPV23) in juvenile idiopathic arthritis (JIA) patients under conventional DMARDs with or without anti-TNF therapy. The influences of demographic data, disease activity and treatment on immune response and the potential ...

journal_title：Vaccine

authors： Aikawa NE,França IL,Ribeiro AC,Sallum AM,Bonfa E,Silva CA

更新日期：2015-01-29 00:00:00

abstract：:It is generally accepted that the introduction of hepatitis B vaccine to national programmes of immunization in developing countries is desirable, but it has so far been constrained by the high cost of the vaccine. To determine the potential minimal costs of the vaccine, a study has been carried out of the production ...

journal_title：Vaccine

authors： Mahoney RT

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Germany introduced routine varicella (V) vaccination in 2004. Due to a slightly increased risk of febrile convulsions after first-dose application of combined measles-mumps-rubella-varicella (MMRV) vaccine separate first-dose vaccinations with MMR and monovalent V vaccine were recommended in September 2011. ...

journal_title：Vaccine

authors： Streng A,Liese JG

更新日期：2014-02-12 00:00:00

abstract：BACKGROUND:Immunization programs currently measure coverage by assessing the proportion of children 12-24 months who have been immunized but this does not address the important question of when the scheduled vaccines were administered. Data capturing the timing of vaccination in first 6 months, when severe disease is m...

journal_title：Vaccine

authors： Hughes MM,Katz J,Englund JA,Khatry SK,Shrestha L,LeClerq SC,Steinhoff M,Tielsch JM

更新日期：2016-02-10 00:00:00

abstract：:A total of 105 hybridomas secreting anti-Japanese encephalitis (JE) virus monoclonal antibodies (mAbs) were generated from six fusions against four strains of JE virus: wild-type strains SA14 and G8924 and live attenuated vaccines SA14-5-3 and SA14-14-2 (PDK-9). Most of the mAbs (87%) elicited haemagglutination inhibi...

journal_title：Vaccine

authors： Sil BK,Wills MR,Cao JX,Sharda R,Islam MA,Stagg DJ,Jennings AD,Gibson CA,Barrett AD

更新日期：1992-01-01 00:00:00

abstract：:We reviewed studies of rotavirus in MEDLINE and the Chinese literature to get a preliminary estimate of the burden of rotavirus gastroenteritis in China and the epidemiology of the disease. Studies were selected if they were conducted for a period 1 year or more, had more than 100 patients enrolled, and used an accept...

journal_title：Vaccine

authors： Orenstein EW,Fang ZY,Xu J,Liu C,Shen K,Qian Y,Jiang B,Kilgore PE,Glass RI

更新日期：2007-01-05 00:00:00

abstract：:The replication of simian immunodeficiency virus (SIV) in acutely infected CD4+ cells can be inhibited in vitro by CD8-suppressor factors (SF) and beta-chemokines induced by immunization of macaques with SIV gp120 and p27 in Alum. A comparison between intradermal, naso-rectal-i.m. and targeted iliac lymph node (TILN) ...

journal_title：Vaccine

authors： Wang Y,Tao L,Mitchell E,Bergmeier L,Doyle C,Lehner T

更新日期：1999-04-09 00:00:00

abstract：:The frequent outbreak of respiratory infectious diseases such as influenza and pulmonary tuberculosis calls for new immunization strategies with high effectiveness. Nasal immunization is one of the most potential methods to prevent the diseases infected through the respiratory tract. In this study, we designed a water...

journal_title：Vaccine

authors： Liu Q,Zhang C,Zheng X,Shao X,Zhang X,Zhang Q,Jiang X

更新日期：2014-05-07 00:00:00

abstract：:The prospective studies available today confirm the experience gained from several retrospective studies that TBE is a disease with a severe acute clinical course and considerable long-term morbidity. A defined post-encephalitic TBE syndrome exists, causing long-lasting morbidity that often affects the quality of life...

journal_title：Vaccine

authors： Haglund M,Günther G

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:In early 2011, following an increased number of reports of severe vaccine-related injection site reactions, Australian authorities recommended against administering repeat doses of the 23-valent pneumococcal polysaccharide vaccine (23vPPV) in otherwise healthy adults. The aim of this study was to assess a so...

journal_title：Vaccine

authors： Trinh L,Macartney K,McIntyre P,Chiu C,Dey A,Menzies R

更新日期：2017-03-13 00:00:00

abstract：:There is an urgent need for an effective vaccine against human disease caused by Burkholderia pseudomallei, and although a wide range of candidates have been tested in mice none provide high level protection. We considered this might reflect the inability of these vaccine candidates to protect against chronic disease....

journal_title：Vaccine

authors： Champion OL,Gourlay LJ,Scott AE,Lassaux P,Conejero L,Perletti L,Hemsley C,Prior J,Bancroft G,Bolognesi M,Titball RW

更新日期：2016-03-29 00:00:00

abstract：:Bacterial infectious diseases remain the single most important threat to health worldwide. Although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed to provide efficacious solutions against many others. The advent of whole-genome sequencing changed the ...

journal_title：Vaccine

authors： Serruto D,Serino L,Masignani V,Pizza M

更新日期：2009-05-26 00:00:00

abstract：:Long-term protection of rabbits that had been vaccinated with two doses of a recombinant protective antigen (rPA) vaccine was examined against an aerosol spore challenge with the Ames isolate of Bacillus anthracis at 6 and 12 months. At 6 months after the primary injection, survival was 74.1% (20/27) with quantitative...

journal_title：Vaccine

authors： Little SF,Ivins BE,Webster WM,Fellows PF,Pitt ML,Norris SL,Andrews GP

更新日期：2006-03-24 00:00:00