Evaluation of 12 stabilizers in a developed attenuated Salmonella Enteritidis vaccine.

abstract：:The immunological enhancement characteristics of the immunopotentiator CVC1302 were evaluated for foot-and-mouth disease virus (FMDV) inactivated vaccine in pigs. Eight-week-old piglets were vaccinated with the foot-and-mouth disease (FMD) vaccine alone (FMD-vaccine group) or with the addition of CVC1302 (FMD-CVC1302 ...

journal_title：Vaccine

authors： Chen J,Yu X,Zheng Q,Hou L,Du L,Zhang Y,Qiao X,Hou J,Huang K

更新日期：2018-12-18 00:00:00

abstract：:Reductive amination coupling an aldehyde-containing polysaccharide, generated by periodate oxidation, with the amino groups in protein has been widely used in the synthesis of glycoconjugate vaccines. The conjugation is often achieved under slightly basic conditions via a Schiff's base intermediate followed by its red...

journal_title：Vaccine

authors： Zou W,Williams D,Cox A

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:PCV13 (conjugated polysaccharide) and PPSV23 (polysaccharide only) are two licensed vaccines targeting S. pneumoniae. The role of CD4 T-cell responses in pneumococcal vaccines among healthy participants and their impact on antibodies is not yet known. METHODS:Ten adults (5 old and 5 young) received PCV13 (p...

journal_title：Vaccine

authors： Sterrett S,Peng BJ,Burton RL,LaFon DC,Westfall AO,Singh S,Pride M,Anderson AS,Ippolito GC,Schroeder HW Jr,Nahm MH,Krishna Prasad A,Goepfert P,Bansal A

更新日期：2020-02-11 00:00:00

abstract：:The recombinant vaccinia viruses expressing the surface protein of Neospora caninum tachyzoite, NcSAG1 or NcSRS2, were constructed. The vaccination with these recombinant viruses could protect effectively the parasite invasion in a mouse model system. The vaccine efficacy of NcSRS2 was higher than that of NcSAG1. The ...

journal_title：Vaccine

authors： Nishikawa Y,Inoue N,Xuan X,Nagasawa H,Igarashi I,Fujisaki K,Otsuka H,Mikami T

更新日期：2001-01-08 00:00:00

abstract：:In presence of low or high levels of rotavirus-specific maternal antibodies, the ability of newborn mice to respond to immunization with rotavirus RF 8*-2/6/7 VLPs, was evaluated. After parenteral vaccination, 100% of offspring born to low-antibody-titer dams developed rotavirus-specific IgG antibodies (n=7). In contr...

journal_title：Vaccine

authors： Johansson E,Istrate C,Charpilienne A,Cohen J,Hinkula J,Poncet D,Svensson L,Johansen K

更新日期：2008-02-06 00:00:00

abstract：BACKGROUND:Shigellae cause severe disease in endemic countries, especially in children. Several efficacy trials have been conducted with candidate vaccines against Shigellae, but the lack of protection, the safety concerns, or manufacturing challenges hindered successful market approval. Conjugated vaccines have been s...

journal_title：Vaccine

authors： Hatz CF,Bally B,Rohrer S,Steffen R,Kramme S,Siegrist CA,Wacker M,Alaimo C,Fonck VG

更新日期：2015-08-26 00:00:00

abstract：:The objective of this study was to investigate the prevalence of hepatitis B markers in a representative sample of 2142 subjects in Catalonia, Spain, and to compare it with previous studies. Multiple logistical regression analysis was carried out to determine variables associated with the markers studied. The prevalen...

journal_title：Vaccine

authors： Domínguez A,Bruguera M,Vidal J,Plans P,Salleras L

更新日期：2000-05-08 00:00:00

abstract：:An ELISA-immunocapture assay was developed for quantification of influenza neuraminidases (N2 and B), with a sensitivity about 10 ng neuramidase(NA)/ml. This sensitive and specific assay was applied to several trivalent vaccine preparations (1997/1998 and 1998/1999). It was shown capable to detect 3.5-6.9 microg NA/ml...

journal_title：Vaccine

authors： Aymard M

更新日期：2002-05-15 00:00:00

abstract：:The principle of deliberately infecting humans with infectious agents in a controlled setting, so-called controlled human infections (CHI), is not novel. Many CHI models have a long history and were established decades ago such as the intentional exposure to yellow fever and dengue performed in the 1900's (Reed, 1902)...

journal_title：Vaccine

authors： Roestenberg M,Mo A,Kremsner PG,Yazdanbakhsh M

更新日期：2017-12-18 00:00:00

abstract：:The ability to readily elicit broadly neutralizing antibodies to HIV-1 remains elusive. We and others have hypothesized that interaction of the viral envelope glycoprotein (Env, gp120-gp41) with its receptor molecules could enhance the exposure of conserved epitopes that may facilitate the elicitation of broadly neutr...

journal_title：Vaccine

authors： Xiao X,Phogat S,Shu Y,Phogat A,Chow YH,Wei OL,Goldstein H,Broder CC,Dimitrov DS

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:Despite the enormous benefits of childhood and maternal immunisation to individual and population health, the uptake of maternal vaccines during pregnancy remains suboptimal. Midwives are a trusted information source for parents and play an important role in the provision of immunisation information. Under...

journal_title：Vaccine

authors： Frawley JE,McKenzie K,Sinclair L,Cummins A,Wardle J,Hall H

更新日期：2020-01-10 00:00:00

abstract：:Bovine papillomaviruses (BPVs) are the causative agent of bovine teat papillomatosis, which can lead to severe economic losses in dairy cattle. Among the 14 identified BPV genotypes, BPV type 6 (BPV6) is the most frequently detected in teat papilloma lesions, and is therefore thought to play a major role in teat papil...

journal_title：Vaccine

authors： Watanabe S,Iizuka T,Hatama S,Kanno T,Mase M,Shibahara T

更新日期：2017-10-13 00:00:00

abstract：:Plasmodium falciparum Pfs25 antigen, expressed on the surface of zygotes and ookinetes, is one of the leading targets for the development of a malaria transmission-blocking vaccine (TBV). Our laboratory has been evaluating DNA plasmid based Pfs25 vaccine in mice and non-human primates. Previously, we established that ...

journal_title：Vaccine

authors： Kumar R,Nyakundi R,Kariuki T,Ozwara H,Nyamongo O,Mlambo G,Ellefsen B,Hannaman D,Kumar N

更新日期：2013-06-28 00:00:00

abstract：BACKGROUND:The present study evaluated immunogenicity and tolerance of two-dose influenza A/H1N1pdm09 vaccination in allogeneic hematopoietic stem cell transplantation (HSCT) recipients, and compared the vaccine-induced humoral response to that triggered by natural infection in another group of HSCT patients. METHODS:...

journal_title：Vaccine

authors： Dhédin N,Krivine A,Le Corre N,Mallet A,Lioure B,Bay JO,Rubio MT,Agape P,Thiébaut A,Le Goff J,Autran B,Ribaud P

更新日期：2014-01-23 00:00:00

abstract：:Strains of Newcastle disease virus (NDV) can be separated into genotypes based on genome differences even though they are antigenically considered to be of a single serotype. It is widely recognized that an efficacious Newcastle disease (ND) vaccine made with any NDV does induce protection against morbidity and mortal...

journal_title：Vaccine

authors： Miller PJ,King DJ,Afonso CL,Suarez DL

更新日期：2007-10-10 00:00:00

abstract：:Hemagglutinin, the major surface protein of influenza viruses, was recombinantly expressed in eukaryotic cells as a monomer instead of its native trimer, and was only immunogenic when administered with an adjuvant [Pion et al. 2014]. In order to multimerize this antigen to increase its immunogenicity, a cysteine-rich ...

journal_title：Vaccine

authors： Peubez I,Margot S,Buffin S,Pion C,Bernard MC,Dinadayala P,Poncet D,Deloire S,Marco S,Legastelois I

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys. METHODS:The cultures of SARS coronavirus (SARS-CoV) BJ-01 strain infected Vero cells we...

journal_title：Vaccine

authors： Qin E,Shi H,Tang L,Wang C,Chang G,Ding Z,Zhao K,Wang J,Chen Z,Yu M,Si B,Liu J,Wu D,Cheng X,Yang B,Peng W,Meng Q,Liu B,Han W,Yin X,Duan H,Zhan D,Tian L,Li S,Wu J,Tan G,Li Y,Li Y,Liu Y,Liu H,Lv F

更新日期：2006-02-13 00:00:00

abstract：:Strict age limits for receipt of rotavirus vaccines and simultaneous use of vaccines requiring two (Rotarix(®)) and three (RotaTeq(®)) doses in Australia may impact on coverage and timeliness of other vaccines in the infant schedule. Using data from the Australian Childhood Immunisation Register (ACIR), coverage and t...

journal_title：Vaccine

authors： Hull BP,Menzies R,Macartney K,McIntyre PB

更新日期：2013-04-08 00:00:00

abstract：:The apical membrane antigen 1 (AMA1) of malaria parasites is a leading vaccine candidate. Its expression in merozoites and sporozoites and its importance for erythrocyte and hepatocyte invasion underline the significance of both humoral and cellular immunities against this antigen in malaria protection. We have genera...

journal_title：Vaccine

authors： Miao J,Li X,Liu Z,Xue C,Bujard H,Cui L

更新日期：2006-09-11 00:00:00

abstract：:The use of pneumococcal polysaccharide vaccine (PPV) is low in some countries, maybe because of doubts regarding its efficacy. This meta-analysis aims at combining evidence from randomized trials of PPV assessing its efficacy in preventing Streptococcus pneumoniae related diseases in immunocompetent adults. In the fou...

journal_title：Vaccine

authors： Cornu C,Yzèbe D,Léophonte P,Gaillat J,Boissel JP,Cucherat M

更新日期：2001-09-14 00:00:00

abstract：:The current human whole-cell vaccine is ineffective against pneumonic plague caused by typical F1 capsule positive (F1+) strains of Yersinia pestis. The authors found this vaccine to also be ineffective against F1-negative (F1-) Y. pestis strains, which have been isolated from a human case and from rodents. For these ...

journal_title：Vaccine

authors： Heath DG,Anderson GW Jr,Mauro JM,Welkos SL,Andrews GP,Adamovicz J,Friedlander AM

更新日期：1998-07-01 00:00:00

abstract：:In order to establish a firm preventive measure for tick-borne encephalitis (TBE) in Japan, we evaluated the immune response of European vaccine against Japanese TBE virus strain (Oshima 5-10) for man and mouse. Furthermore, the efficacy of pre- and post-exposure protection by a polyclonal rabbit anti-TBE virus serum ...

journal_title：Vaccine

authors： Chiba N,Osada M,Komoro K,Mizutani T,Kariwa H,Takashima I

更新日期：1999-03-17 00:00:00

abstract：:The modular binding sites on the influenza A(H3N2) hemagglutinin protein are under significant pressure to acquire mutations in order to evade human antibody recognition. Analysis of these hemagglutinin epitopes in the strains circulating during 2017/18 and early 2018/19 identified the emergence of a new antigenic clu...

journal_title：Vaccine

authors： Bonomo ME,Kim RY,Deem MW

更新日期：2019-05-27 00:00:00

abstract：:Plasmid DNA vaccines encoding full-length antigen often induce both potent antibody and cytotoxic T lymphocyte (CTL) responses. Here, we examine strategies to exclusively elicit epitope-specific CTL responses using DNA constructs expressing a minimal class I MHC-restricted epitope of the nucleoprotein (NP) of influenz...

journal_title：Vaccine

authors： Iwasaki A,Dela Cruz CS,Young AR,Barber BH

更新日期：1999-04-09 00:00:00

abstract：:Enterovirus type 71 (EV71) and coxsackievirus A 16 (CA16) are recognized as the major pathogens responsible for human hand-foot-mouth disease. To develop a bivalent EV71-CA16 vaccine, rhesus macaques immunized with two doses of this vaccine via the intradermal route were challenged with EV71 or CA16, and their clinica...

journal_title：Vaccine

authors： Fan S,Liao Y,Jiang G,Jiang L,Wang L,Xu X,Feng M,Yang E,Zhang Y,Cui W,Li Q

更新日期：2020-02-18 00:00:00

abstract：:Using HIV-1 envelope protein (Env)-based immunogens that closely mimic the conformation of functional HIV-1 Envs and represent the isolates prevalent in relevant geographical region is considered a rational approach towards developing HIV vaccine. We recently reported that like clade B Env, JRFL, membrane bound Indian...

journal_title：Vaccine

authors： Shrivastava T,Samal S,Tyagi AK,Goswami S,Kumar N,Ozorowski G,Ward AB,Chakrabarti BK

更新日期：2018-03-14 00:00:00

abstract：BACKGROUND:Bacillus Calmette-Guérin (BCG) vaccination is a widely-used public health intervention for tuberculosis (TB) control. In Taiwan, like other intermediate TB burden settings, steadily declining TB incidence raises important questions on whether universal BCG vaccination should be discontinued. Recent surveys o...

journal_title：Vaccine

authors： Fu H,Lin HH,Hallett TB,Arinaminpathy N

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Current national immunisation schedules differ between countries in terms of vaccine formulation, timing of vaccinations and immunisation programme funding and co-ordination. As a result, some HIV infected paediatric population may be left susceptible to vaccine preventable infections. Vaccines used in healt...

journal_title：Vaccine

authors： Bamford A,Manno EC,Mellado MJ,Spoulou V,Marques L,Scherpbier HJ,Niehues T,Oldakowska A,Rossi P,Palma P,PENTA-vac Group.

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:Due in part to declining vaccination rates, in 2018 over 20 states reported at least one case of measles, and over 40,000 cases were confirmed in Europe. Anti-vaccine posts on social media may be facilitating anti-vaccination behaviour. This study aimed to systematically characterize (1) individuals known to...

journal_title：Vaccine

authors： Hoffman BL,Felter EM,Chu KH,Shensa A,Hermann C,Wolynn T,Williams D,Primack BA

更新日期：2019-04-10 00:00:00

abstract：:Mucosal adjuvants are important to overcome the state of immune tolerance normally associated with mucosal delivery and to enhance adaptive immunity to often-weakly immunogenic subunit vaccine antigens. Unfortunately, adverse side effects of many experimental adjuvants limit the number of adjuvants approved for vaccin...

journal_title：Vaccine

authors： Hickey DK,Aldwell FE,Beagley KW

更新日期：2009-10-19 00:00:00