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Expression of enterotoxigenic Escherichia coli colonization factors in Vibrio cholerae.

Abstract：

:As a first step towards a vaccine against diarrhoeal disease caused by enterotoxigenic Escherichia coli (ETEC), we have studied the expression of several ETEC antigens in the live attenuated Vibrio cholerae vaccine strain CVD 103-HgR. Colonization factors (CF) CFA/I, CS3, and CS6 were expressed at the surface of V. cholerae CVD 103-HgR. Both CFA/I and CS3 required the co-expression of a positive regulator for expression, while CS6 was expressed without regulation. Up-regulation of CF expression in V. cholerae was very efficient, so that high amounts of CFA/I and CS3 similar to those in wild-type ETEC were synthesized from chromosomally integrated CF and positive regulator loci. Increasing either the operon and/or the positive regulator gene dosage resulted in only a small increase in CFA/I and CS3 expression. In contrast, the level of expression of the non-regulated CS6 fimbriae appeared to be more dependent on gene dosage. While CF expression in wild-type ETEC is known to be tightly thermoregulated and medium dependent, it seems to be less stringent in V. cholerae. Finally, co-expression of two or three CFs in the same strain was efficient even under the control of one single regulator gene.

journal_name

Vaccine

journal_title

Vaccine

authors

Favre D,Lüdi S,Stoffel M,Frey J,Horn MP,Dietrich G,Spreng S,Viret JF

doi

10.1016/j.vaccine.2006.02.052

subject

Has Abstract

pub_date

2006-05-15 00:00:00

pages

4354-68

issue

20

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)00248-9

journal_volume

24

pub_type

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