Abstract：
:Safety and efficacy of adjuvanted vaccines in autoimmune individuals raises growing clinical and scientific interest. Protection from influenza would bring particular benefits in these patients with common cardiac and respiratory impairment. This study evaluates efficacy, clinical safety and immune effects of the administration of a single dose of a virosomal flu vaccine in 46 scleroderma patients. The following parameters were evaluated before and after administration of Inflexal: clinical conditions, inflammation and autoimmunity parameters, humoral response, lymphocyte proliferation and cytokine production upon flu antigen stimulation by specific and non-specific cells. Inflexal was found effective in scleroderma patients. In no subject was worsening of clinical conditions, inflammation and immunological parameters observed.
journal_name
Vaccinejournal_title
Vaccineauthors
Setti M,Fenoglio D,Ansaldi F,Filaci G,Bacilieri S,Sticchi L,Ferrera A,Indiveri F,Ghio Mdoi
10.1016/j.vaccine.2009.01.078subject
Has Abstractpub_date
2009-05-26 00:00:00pages
3367-72issue
25-26eissn
0264-410Xissn
1873-2518pii
S0264-410X(09)00104-2journal_volume
27pub_type
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