Abstract:
:Gag-CD8+ T cell responses are associated with immune control of HIV infection. Since during HIV infection Nef impairs T cell responses, we evaluated whether deletion of nef from a non-infectious HIV DNA vaccine (Delta4 Nef+), creating Delta5 Nef(-), would affect its immunogenicity. When compared with Delta4, mice injected with Delta5 developed significantly lower CD8+ T cell responses to Gag, but no significant change in the responses to Env was observed. In vitro, deletion of Nef abrogated the induced cell death, production of virus-like particles and release of Gag from transfected cells. Thus, the effect of Nef in causing extrusion of Gag might adjuvant the CD8+ T cell responses to Gag in DNA vaccine.
journal_name
Vaccinejournal_title
Vaccineauthors
Arrode G,Hegde R,Jin Y,Singh DK,Narayan O,Chebloune Ydoi
10.1016/j.vaccine.2008.05.057subject
Has Abstractpub_date
2008-07-23 00:00:00pages
3795-804issue
31eissn
0264-410Xissn
1873-2518pii
S0264-410X(08)00608-7journal_volume
26pub_type
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