Nef modulates the immunogenicity of Gag encoded in a non-infectious HIV DNA vaccine.

Abstract:

:Gag-CD8+ T cell responses are associated with immune control of HIV infection. Since during HIV infection Nef impairs T cell responses, we evaluated whether deletion of nef from a non-infectious HIV DNA vaccine (Delta4 Nef+), creating Delta5 Nef(-), would affect its immunogenicity. When compared with Delta4, mice injected with Delta5 developed significantly lower CD8+ T cell responses to Gag, but no significant change in the responses to Env was observed. In vitro, deletion of Nef abrogated the induced cell death, production of virus-like particles and release of Gag from transfected cells. Thus, the effect of Nef in causing extrusion of Gag might adjuvant the CD8+ T cell responses to Gag in DNA vaccine.

journal_name

Vaccine

journal_title

Vaccine

authors

Arrode G,Hegde R,Jin Y,Singh DK,Narayan O,Chebloune Y

doi

10.1016/j.vaccine.2008.05.057

subject

Has Abstract

pub_date

2008-07-23 00:00:00

pages

3795-804

issue

31

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)00608-7

journal_volume

26

pub_type

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