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Effectiveness of childhood vaccination against rotavirus in sub-Saharan Africa: the case of Nigeria.

Abstract：

:Rotavirus diarrhoea is associated with high childhood mortality in developing countries. A new vaccine was recently licensed in Mexico. The objective of this study was to assess the effectiveness of routine childhood vaccination by this new vaccine in a developing country. We constructed a decision tree to compare two alternatives: "no vaccination programme" and "vaccination programme". The estimates used for disease incidence, vaccine efficacy and coverage rates were derived from published data. We followed a hypothetical Nigerian cohort from birth to age five. The vaccine programme would prevent 284,000 cases of rotavirus diarrhoea annually and 6129 deaths due to the disease. In this study in a sub-Saharan country, we showed that rotavirus vaccination with a new vaccine substantially reduces the number of deaths from rotavirus diarrhoea and may be of great use in developing countries.

journal_name

Vaccine

journal_title

Vaccine

authors

Melliez H,Boelle PY,Baron S,Mouton Y,Yazdanpanah Y

doi

10.1016/j.vaccine.2006.07.038

subject

Has Abstract

pub_date

2007-01-04 00:00:00

pages

298-305

issue

2

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(06)00891-7

journal_volume

25

pub_type

杂志文章

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