Abstract：
:In this study we have investigated the immunogenicity and antigenicity of synthetic immunocontraceptive vaccine candidates containing T- and B-cell epitopes arranged in different geometries. Two epitopes were selected, a B-cell epitope from fox sperm lactate dehydrogenase C(4) and a B-cell epitope from murine zona pellucida protein 3. Both were immunogenic in BALB/c mice when coupled to defined T helper cell determinants, eliciting antibodies which bound to the corresponding B-cell epitope and also to the recombinant protein. Because each of these proteins represent important components in the fertilisation process the results encourage further investigation of synthetic immunocontraceptive vaccines.
journal_name
Vaccinejournal_title
Vaccineauthors
Sadler K,Bird PH,Brown LE,Jackson DCdoi
10.1016/s0264-410x(99)00255-8subject
Has Abstractpub_date
1999-10-14 00:00:00pages
416-25issue
5-6eissn
0264-410Xissn
1873-2518pii
S0264410X99002558journal_volume
18pub_type
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