Poly(propyleneimine) dendrimer and dendrosome mediated genetic immunization against hepatitis B.

abstract：INTRODUCTION:Immunization education for physicians-in-training is crucial to address vaccine concerns in clinical practice. Vaccine education is not standardized across residency programs. The Collaboration for Vaccination Education and Research (CoVER) team developed an online curriculum for pediatric (Peds) and famil...

journal_title：Vaccine

authors： Pahud B,Elizabeth Williams S,Lee BR,Lewis KO,Middleton DB,Clark S,Humiston SG

更新日期：2020-10-27 00:00:00

abstract：:Millions of people worldwide are currently infected with human papillomaviruses (HPVs). A therapeutic HPV vaccine would have widespread applicability because HPV-associated lesions are difficult to treat and may progress to carcinoma. We developed three attenuated VSV recombinants expressing the cottontail rabbit papi...

journal_title：Vaccine

authors： Brandsma JL,Shlyankevich M,Buonocore L,Roberts A,Becker SM,Rose JK

更新日期：2007-01-08 00:00:00

abstract：:Outer membrane protein (OMP) vaccines are being developed against Neisseria meningitidis serogroup B which may provide protection against common circulating serotypes and serosubtypes in some countries. However, limited data is available in Europe from genosubtyping meningococci. We therefore undertook a retrospective...

journal_title：Vaccine

authors： Clarke SC,Diggle MA,Mölling P,Unemo M,Olcén P

更新日期：2003-06-02 00:00:00

abstract：:A formulation of recombinant hepatitis B surface antigen (HBsAg) combined with a novel adjuvant system, SBAS4--a combination of aluminium salt and monophosphoryl lipid A (MPL), was assessed in 27 healthy adult volunteers with a commercial vaccine (Engerix-B) as control. After three doses (0, 1, 6 months schedule), rea...

journal_title：Vaccine

authors： Thoelen S,Van Damme P,Mathei C,Leroux-Roels G,Desombere I,Safary A,Vandepapeliere P,Slaoui M,Meheus A

更新日期：1998-04-01 00:00:00

abstract：INTRODUCTION:The World Health Organization recommends that as part of the polio end-game strategy a dose of inactivated poliovirus vaccine (IPV) be introduced by the end of 2015 in all countries currently using only oral poliovirus vaccine (OPV). Administration of fractional dose (1/5 of full dose) IPV (fIPV) by intrad...

journal_title：Vaccine

authors： Resik S,Tejeda A,Mach O,Sein C,Molodecky N,Jarrahian C,Saganic L,Zehrung D,Fonseca M,Diaz M,Alemany N,Garcia G,Hung LH,Martinez Y,Sutter RW

更新日期：2015-10-26 00:00:00

abstract：:The gene encoding for a major surface glycoprotein, gp63, of Leishmania major was cloned into the eukaryotic expression plasmid pCDNAI with CMV or RSV promoters. The highly susceptible Balb/c mice were injected intramuscularly with 100 micrograms/mouse of the purified plasmid. The plasmids were found to be stable in v...

journal_title：Vaccine

authors： Xu D,Liew FY

更新日期：1994-12-01 00:00:00

abstract：:Immune responses to human rotaviruses were investigated in sheep with a view to obtaining antibodies for passive immunotherapy of humans. Eighteen adult sheep with previous natural exposure to rotavirus serotypes G3 and G6 were immunized parenterally with purified preparations of either individual rotavirus serotypes ...

journal_title：Vaccine

authors： Beards GM,King JA,Mazhar S,Landon J,Desselberger U

更新日期：1993-01-01 00:00:00

abstract：:A highly efficacious vaccine is required to counteract a threat of an avian influenza pandemic. Increasing the potency of vaccines by adjuvation is essential not only to overcome generally low immunogenicity of pandemic strains, but also to allow dose sparing and as such to make it feasible to satisfy huge global prod...

journal_title：Vaccine

authors： Radosević K,Rodriguez A,Mintardjo R,Tax D,Bengtsson KL,Thompson C,Zambon M,Weverling GJ,Uytdehaag F,Goudsmit J

更新日期：2008-07-04 00:00:00

abstract：:T-lymphocyte responses to influenza vaccination were measured in healthy young and older adult volunteers. All participants were vaccinated with the 1995-96 trivalent influenza vaccine. Cytokine and granzyme B levels were measured in peripheral blood mononuclear cells (PBMC) cultures after virus stimulation, prior to ...

journal_title：Vaccine

authors： McElhaney JE,Upshaw CM,Hooton JW,Lechelt KE,Meneilly GS

更新日期：1998-11-01 00:00:00

abstract：:Oligoclonal combinations of several monoclonal antibodies (MAbs) are being considered for the treatment of various infectious pathologies. These combinations are less sensitive to antigen structural changes than individual MAbs; at the same time, their characteristics can be more efficiently controlled than those of p...

journal_title：Vaccine

authors： Lukic I,Filipovic A,Inic-Kanada A,Marinkovic E,Miljkovic R,Stojanovic M

更新日期：2018-06-18 00:00:00

abstract：INTRODUCTION:This multi-center, hospital-based observational study determined the seroprevalence of pertussis antibodies amongst healthcare professionals from three different hospitals in Spain to ascertain the health status of professionals attending to susceptible groups who are at risk of contracting and transmittin...

journal_title：Vaccine

authors： Rodríguez de la Pinta ML,Castro Lareo MI,Ramon Torrell JM,García de Lomas J,Devadiga R,Reyes J,McCoig C,Tafalla M,García-Corbeira P

更新日期：2016-02-17 00:00:00

abstract：BACKGROUND:As part of the regulatory requirements, serological evaluation of trivalent inactivated influenza vaccines must be performed before annual re-licensure in the European Union. These studies are typically set up as uncontrolled, open label trials including 2 groups of at least 50 healthy adults and healthy eld...

journal_title：Vaccine

authors： Voordouw AC,Beyer WE,Smith DJ,Sturkenboom MC,Stricker BH

更新日期：2009-12-11 00:00:00

abstract：BACKGROUND:Reactions to DTwP vaccine are well known and are a matter of great concern, much for the development of next generation combination vaccines. To avoid such reactions which occur from foreign compounds, WHO suggested manufacture of DTwP vaccine using semi-synthetic medium. The phase III trial reported here wa...

journal_title：Vaccine

authors： Sharma H,Patil V,Sharma D,Kapre S,Jadhav S,Ravetkar S,Kumar R,Bahl S,Parekh S,Chakravarty A

更新日期：2012-09-21 00:00:00

abstract：:Recently, an outbreak of fatal infection caused by a pantropic variant (strain CB/05) of canine coronavirus (CCoV) has been reported. In this study, evidence is provided that immunity induced by natural exposure to enteric CCoV is not fully protective against strain CB/05. Twenty-two, 10-week-old beagles with a recent...

journal_title：Vaccine

authors： Decaro N,Elia G,Martella V,Campolo M,Mari V,Desario C,Lucente MS,Lorusso E,Kanellos T,Gibbons RH,Buonavoglia C

更新日期：2010-01-08 00:00:00

abstract：:Oral poliovirus vaccine (OPV) is tested for safety by evaluation of neurovirulence in rhesus and cynomolgus macaques. After intraspinal or intrathalamic injection of varying doses of vaccine, monkeys are followed for 17-21 days, killed, and a histopathological evaluation is made of the severity of poliomyelitis lesion...

journal_title：Vaccine

authors： Nathanson N,Horn SD

更新日期：1992-01-01 00:00:00

abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells of the immune system that are efficient at presenting peptide-antigen for the activation of T cells and are often the cell type of choice for vaccine targeting by virtue of high expression levels of MHC and costimulatory molecules. Since the level o...

journal_title：Vaccine

authors： Neethling FA,Ramakrishna V,Keler T,Buchli R,Woodburn T,Weidanz JA

更新日期：2008-06-13 00:00:00

abstract：:Varied doses of Taishan Pinus massoniana pollen polysaccharide (TPPPS) and Astragalus polysaccharide (APS) extracted by hot water extraction and ethanol precipitation method were added to the vaccine in order to prepare polysaccharide-rabbit haemorrhagic disease (RHD) tissue inactivated vaccine. The purpose was to stu...

journal_title：Vaccine

authors： Wei K,Sun Z,Yan Z,Tan Y,Wang H,Zhu X,Wang X,Sheng P,Zhu R

更新日期：2011-03-21 00:00:00

abstract：BACKGROUND:During the past decade, in the United States, an increasing number of hepatitis B outbreaks have been reported in assisted living facilities (ALFs) as a result of breaches in infection control practices. We evaluated the seroprotection rates conferred by hepatitis B vaccine among older adults during a respon...

journal_title：Vaccine

authors： Tohme RA,Awosika-Olumo D,Nielsen C,Khuwaja S,Scott J,Xing J,Drobeniuc J,Hu DJ,Turner C,Wafeeg T,Sharapov U,Spradling PR

更新日期：2011-11-21 00:00:00

abstract：:We have previously described the generation of HIV-1 V3-specific cytotoxic T-lymphocytes (CTL) responses in BALB/c (H-2d) mice following immunization with Ty-virus-like particles carrying the V3 loop of gp120 (V3-VLPs) without adjuvant. In this study the effects of various adjuvants on CTL induction by V3-VLPs was exa...

journal_title：Vaccine

authors： Harris SJ,Woodrow SA,Gearing AJ,Adams SE,Kingsman AJ,Layton GT

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Children are scheduled to receive 18-20 immunizations before their 18th birthday in England and Wales; this approximates to 13 million vaccines administered per annum. Each immunization represents a potential opportunity for immunization-related error and effective immunization is imperative to maintain the ...

journal_title：Vaccine

authors： Rees P,Edwards A,Powell C,Evans HP,Carter B,Hibbert P,Makeham M,Sheikh A,Donaldson L,Carson-Stevens A

更新日期：2015-07-31 00:00:00

abstract：:Based on the reactivities of monoclonal antibodies, we previously reported that 25 Japanese encephalitis (JE) virus strains fell into five antigenic groups: Nakayama, Beijing-1, Kamiyama, 691004 and Muar. In the present study, we produced monoclonal antibodies against the Beijing-1 strain and obtained the Beijing-1 gr...

journal_title：Vaccine

authors： Satake Y,Hasegawa H,Yoshida M,Kobayashi Y

更新日期：1994-06-01 00:00:00

abstract：:The outbreak of the 2009 influenza pandemic underscored the important role of swine in influenza virus evolution and the emergence of novel viruses with pandemic potential. Vaccination is the most common practice to control swine influenza in swine industry. Influenza virus-like particle (VLP) vaccines are an alternat...

journal_title：Vaccine

authors： Pyo HM,Masic A,Woldeab N,Embury-Hyatt C,Lin L,Shin YK,Song JY,Babiuk S,Zhou Y

更新日期：2012-02-08 00:00:00

abstract：:The potency of genetic immunization observed in the mouse has demonstrated the utility of DNA vaccines to induce cell-mediated and humoral immune responses. However, it has been relatively difficult to generate comparable responses in non-rodent species. The use of molecular adjuvants may increase the magnitude of the...

journal_title：Vaccine

authors： Maue AC,Waters WR,Palmer MV,Nonnecke BJ,Minion FC,Brown WC,Norimine J,Foote MR,Scherer CF,Estes DM

更新日期：2007-06-11 00:00:00

abstract：INTRODUCTION:Hepatitis B is a major preventable cause of morbidity and mortality from chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. We aimed to evaluate the performance and outcomes of the Korean Perinatal Hepatitis B Prevention Programme (PHBPP) and to investigate the impact of the current post-exp...

journal_title：Vaccine

authors： Yang TU,Jung CW,Kim D,Park HA,Jee Y

更新日期：2020-07-22 00:00:00

abstract：IMPORTANCE:Disparities in childhood vaccination rates persist. OBJECTIVE:To evaluate the impact of an enriched medical home intervention using community health workers on improving immunization adherence among young children. DESIGN:The intervention group received home visits from trained community health workers to ...

journal_title：Vaccine

authors： Pati S,Ladowski KL,Wong AT,Huang J,Yang J

更新日期：2015-11-17 00:00:00

abstract：:Intranasal inactivated influenza vaccines have the advantage over parenteral vaccines in that they are not associated with the pain of an injection. However, they would be most useful if they were available for all age groups, including high-risk groups, and also would provide cross-protection against variant virus st...

journal_title：Vaccine

authors： Tamura S

更新日期：2010-08-31 00:00:00

abstract：:Development of active targeted immunotherapeutics is a rapid developing field in the arena of chronic infectious diseases. The question of repeated, closely spaced administration of immunotherapeutics to achieve a rapid impact on the replicating agent is an important one. We analyzed here, using a prototype adenovirus...

journal_title：Vaccine

authors： Boukhebza H,Dubois C,Koerper V,Evlachev A,Schlesinger Y,Menguy T,Silvestre N,Riedl P,Inchauspé G,Martin P

更新日期：2014-05-30 00:00:00

abstract：:Immune responses to poorly immunogenic antigens, such as polysaccharides, can be enhanced by conjugation to carriers. Our previous studies indicate that conjugation to Vi polysaccharide of Salmonella Typhi may also enhance immunogenicity of some protein carriers. We therefore explored the possibility of generating a b...

journal_title：Vaccine

authors： An SJ,Scaria PV,Chen B,Barnafo E,Muratova O,Anderson C,Lambert L,Chae MH,Yang JS,Duffy PE

更新日期：2018-05-17 00:00:00

abstract：:Fluid cholera vaccine was examined for its stability at 4-8 degrees C, 20-25 degrees C and 37 degrees C with regard to the number of organisms present and the total nitrogen content. Ten batches of fluid cholera vaccine manufactured at the Central Research Institute, Kasauli, India were taken for the study. The number...

journal_title：Vaccine

authors： Gupta RK,Maheshwari SC,Sharma SB,Ahuja S,Saxena SN

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Each year a substantial number of Dutch elderly suffers from herpes zoster (HZ), caused by the reactivation of the varicella zoster virus (VZV). A potential complication of HZ is postherpetic neuralgia (PHN) which results in a prolonged loss of quality of life. A large randomized clinical trial, labelled the...

journal_title：Vaccine

authors： de Boer PT,Pouwels KB,Cox JM,Hak E,Wilschut JC,Postma MJ

更新日期：2013-02-18 00:00:00