Financing children's vaccines.

abstract：:Although vaccination against Streptococcus pneumoniae (S. pneumoniae) and Haemophilus influenzae type b (Hib) is recommended for immunocompromised patients, such as patients with B-cell chronic lymphocytic leukaemia (B-CLL), its protective effect is questionable. We studied antibody responses to pneumococcal polysacch...

journal_title：Vaccine

authors： Hartkamp A,Mulder AH,Rijkers GT,van Velzen-Blad H,Biesma DH

更新日期：2001-02-08 00:00:00

abstract：:NetB (necrotic enteritis toxin B) is a recently identified β-pore-forming toxin produced by Clostridium perfringens. This toxin has been shown to play a major role in avian necrotic enteritis. In recent years, a dramatic increase in necrotic enteritis has been observed, especially in countries where the use of antimic...

journal_title：Vaccine

authors： Fernandes da Costa SP,Mot D,Bokori-Brown M,Savva CG,Basak AK,Van Immerseel F,Titball RW

更新日期：2013-08-20 00:00:00

abstract：:We assessed HPV 16 and 18 antibody responses of female subjects enrolled in a 2- vs. 3-dose quadrivalent HPV (Q-HPV) vaccine trial (ClinicalTrials.gov NCT00501137) using the Merck competitive Luminex (cLIA) and total IgG Luminex (TIgG) immunoassays, and a pseudovirus neutralizing antibody (PsV NAb) assay. Subjects wer...

journal_title：Vaccine

authors： Krajden M,Cook D,Yu A,Chow R,Su Q,Mei W,McNeil S,Money D,Dionne M,Palefsky J,Karunakaran K,Kollmann T,Ogilvie G,Petric M,Dobson S

更新日期：2014-01-23 00:00:00

abstract：:The currently used live-attenuated measles vaccine is very effective although maternal antibody prevents its administration prior to 6 months of age. We are investigating the ability of a DNA vaccine encoding the measles viral hemagglutinin, fusion and nucleoprotein to protect newborn infants from measles. Here, we sh...

journal_title：Vaccine

authors： Premenko-Lanier M,Rota P,Rhodes G,Bellini W,McChesney M

更新日期：2004-01-26 00:00:00

abstract：BACKGROUND AND AIM:Evidence is accumulating that several markers in the human leukocyte antigen (HLA) region have been associated with decreased or increased antibody response to hepatitis B vaccine in different individuals. This meta-analysis is to assess the associations of HLA class II DRB1 and DQB1 alleles with imm...

journal_title：Vaccine

authors： Li ZK,Nie JJ,Li J,Zhuang H

更新日期：2013-09-13 00:00:00

abstract：BACKGROUND:In 2014 the Kenya National Immunization Technical Advisory Group (KENITAG) was asked by the Ministry of Health to provide an evidence-based recommendation on whether the seasonal influenza vaccine should be introduced into the national immunization program (NIP). METHODS:We reviewed KENITAG manuals, reports...

journal_title：Vaccine

authors： Dawa J,Chaves SS,Ba Nguz A,Kalani R,Anyango E,Mutie D,Muthoka P,Tabu C,Maritim M,Amukoye E,Were F,Kenya National Immunization Technical Advisory Group (KENITAG).

更新日期：2019-01-14 00:00:00

abstract：:Despite the availability of anti-microbial agents effective against Neisseria meningitidis, meningococcal disease continues to be a major global health problem, particularly in the very young. Serogroup A meningococci cause large epidemics in sub-Saharan Africa, whilst serogroups B and C organisms are responsible for ...

journal_title：Vaccine

authors： Borrow R,Balmer P,Miller E

更新日期：2005-03-18 00:00:00

abstract：:Immune responses to the infectious bronchitis virus (IBV) nucleocapsid protein were studied using a recombinant-DNA expression product. In mice, a lymphocyte proliferative response and a delayed-type hypersensitivity reaction to IBV were induced upon immunization with this nucleocapsid protein. Next, we studied the ro...

journal_title：Vaccine

authors： Boots AM,Benaissa-Trouw BJ,Hesselink W,Rijke E,Schrier C,Hensen EJ

更新日期：1992-01-01 00:00:00

abstract：:Clostridium difficile infection (CDI) causes nosocomial antibiotic-associated diarrhea and colitis in the developed world. Two potent cytotoxins, toxin A (TcdA) and toxin B (TcdB) are the virulence factors of this disease and can be a good vaccine candidate against CDI. In the present study, we genetically engineered ...

journal_title：Vaccine

authors： Guo S,Yan W,McDonough SP,Lin N,Wu KJ,He H,Xiang H,Yang M,Moreira MA,Chang YF

更新日期：2015-03-24 00:00:00

abstract：:A fusion protein, comprising the B subunit of the heat-labile enterotoxin and a portion of the precursor to the heat-stable enterotoxin of Escherichia coli, has been created by recombinant genetic techniques. It is exported successfully to the bacterial periplasm and assembles into pentamers which retain the ability t...

journal_title：Vaccine

authors： Aitken R,Hirst TR

更新日期：1993-01-01 00:00:00

abstract：:In this paper we give guidance for the design and conduct of vaccine trials against Plasmodium vivax malaria. The paper supplements earlier guidelines on the planning of vaccine trials against Plasmodium falciparum malaria [WHO. Guidelines for the evaluation of Plasmodium falciparum vaccines in populations exposed to ...

journal_title：Vaccine

authors： Mueller I,Moorthy VS,Brown GV,Smith PG,Alonso P,Genton B,WHO Malaria Vaccine Advisory Committee (MALVAC).

更新日期：2009-09-18 00:00:00

abstract：BACKGROUND:Sexual mixing between heterogeneous population subgroups is an integral component of mathematical models of sexually transmitted infections (STIs). This study compares the fit of different mixing representations to survey data and the impact of different mixing assumptions on the predicted benefits of hypoth...

journal_title：Vaccine

authors： Easterly CW,Alarid-Escudero F,Enns EA,Kulasingam S

更新日期：2018-09-05 00:00:00

abstract：:GPI-0100 is a semi-synthetic saponin with modifications designed to augment stability and diminish toxicity. Two batches of GPI-0100 (the second with higher purity) were tested with doses ranging between 100 and 5000 microg in groups of five treated prostate cancer patients who had no evidence of disease except for ri...

journal_title：Vaccine

authors： Slovin SF,Ragupathi G,Fernandez C,Jefferson MP,Diani M,Wilton AS,Powell S,Spassova M,Reis C,Clausen H,Danishefsky S,Livingston P,Scher HI

更新日期：2005-05-02 00:00:00

abstract：:In case of an influenza pandemic, the world will be in a situation where potential vaccine supply will fall short by several billion doses from global needs. The World Health Organization (WHO) convened in Geneva on May 2-3, 2006 a consultation of all stakeholders in influenza vaccines and immunization to identify pra...

journal_title：Vaccine

authors： Kieny MP,Costa A,Hombach J,Carrasco P,Pervikov Y,Salisbury D,Greco M,Gust I,LaForce M,Franco-Paredes C,Santos JI,D'Hondt E,Rimmelzwaan G,Karron R,Fukuda K

更新日期：2006-09-29 00:00:00

abstract：:This report provides an overview of methods used to conduct systematic reviews for the US Food and Drug Administration (FDA) Mini-Sentinel project, which is designed to inform the development of safety monitoring tools for FDA-regulated products including vaccines. The objective of these reviews was to summarize the l...

journal_title：Vaccine

authors： McPheeters ML,Sathe NA,Jerome RN,Carnahan RM

更新日期：2013-12-30 00:00:00

abstract：:We exploited the powerful adjuvant properties of cholera holotoxin (CT) to create a mucosally administered subunit vaccine against respiratory syncytial virus (RSV). A genetically detoxified mutant CT with an E to H substitution at amino acid 29 of the CT-A1 subunit (CT-E29H) was compared to wild type CT for toxicity ...

journal_title：Vaccine

authors： Tebbey PW,Scheuer CA,Peek JA,Zhu D,LaPierre NA,Green BA,Phillips ED,Ibraghimov AR,Eldridge JH,Hancock GE

更新日期：2000-06-01 00:00:00

abstract：:B. pseudomallei is the cause of melioidosis, a serious an often fatal disease of humans and animals. The closely related bacterium B. mallei, which cases glanders, is considered to be a clonal derivative of B. pseudomallei. Both B. pseudomallei and B. mallei were evaluated by the United States and the former USSR as p...

journal_title：Vaccine

authors： Titball RW,Burtnick MN,Bancroft GJ,Brett P

更新日期：2017-10-20 00:00:00

abstract：:Amebiasis remains one of the leading parasitic causes of death worldwide. A vaccine that prevented amebic liver abscess would significantly reduce mortality from this disease. To test the feasibility of a DNA vaccine to prevent amebic liver abscess, we immunized both mice and gerbils with plasmid DNA encoding the seri...

journal_title：Vaccine

authors： Zhang T,Stanley SL Jr

更新日期：1999-12-10 00:00:00

abstract：:Antibodies have the potential to be therapeutic reagents for malaria. Here we describe the production of a novel phage antibody display library against the C-terminal 19kDa region of the Plasmodium yoelii YM merozoite surface protein-1 (MSP1(19)). In vivo studies against homologous lethal malaria challenge show an ant...

journal_title：Vaccine

authors： Vukovic P,Chen K,Qin Liu X,Foley M,Boyd A,Kaslow D,Good MF

更新日期：2002-06-21 00:00:00

abstract：:The objective of this study was to investigate the prevalence of hepatitis B markers in a representative sample of 2142 subjects in Catalonia, Spain, and to compare it with previous studies. Multiple logistical regression analysis was carried out to determine variables associated with the markers studied. The prevalen...

journal_title：Vaccine

authors： Domínguez A,Bruguera M,Vidal J,Plans P,Salleras L

更新日期：2000-05-08 00:00:00

abstract：:Neutralizing antibody is associated with the prevention and clearance of influenza virus infection. Microneutralization (MN) and hemagglutination inhibition (HI) assays are currently used to evaluate neutralizing antibody responses against human and avian influenza viruses, including H5N1. The MN assay is somewhat lab...

journal_title：Vaccine

authors： Tsai C,Caillet C,Hu H,Zhou F,Ding H,Zhang G,Zhou B,Wang S,Lu S,Buchy P,Deubel V,Vogel FR,Zhou P

更新日期：2009-11-12 00:00:00

abstract：:The assignment of infectious potency to test articles of adenovirus has been conducted mainly using classical end-point dilution methods, which rely on virus induced cytopathology to reveal the presence of infectious virus. These assays suffer the disadvantages of labor intensity, duration, throughput restriction and ...

journal_title：Vaccine

authors： Wang F,Puddy AC,Mathis BC,Montalvo AG,Louis AA,McMackin JL,Xu J,Zhang Y,Tan CY,Schofield TL,Wolf JJ,Lewis JA

更新日期：2005-08-22 00:00:00

abstract：:The immunogenic potential of Vibrio cholerae ghosts (VCG) in comparison with heat-killed whole-cell vibrios (WCV) was evaluated after intraperitoneal immunization of adult mice. Swiss white mice received four doses of VCG or WCV intraperitoneally, consisting of 500 micrograms of lyophilized material in 200 microliters...

journal_title：Vaccine

authors： Eko FO,Hensel A,Bunka S,Lubitz W

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated a correlation between Clostridium difficile anti-toxin A serum antibodies and protection against symptomatic disease and recurrence. METHODS:A neutralizing monoclonal antibody to C. difficile toxin A (CDA1) developed by MBL and Medarex, Inc. was studied in a phase II, rand...

journal_title：Vaccine

authors： Leav BA,Blair B,Leney M,Knauber M,Reilly C,Lowy I,Gerding DN,Kelly CP,Katchar K,Baxter R,Ambrosino D,Molrine D

更新日期：2010-01-22 00:00:00

abstract：:The immunogenicity and protective efficacy of a nucleic acid vaccine encoding the herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) gene under the control of the CMV immediate early gene promoter was examined. Mice immunized three times by intramuscular injection with the vaccine developed an HSV specific IgG bu...

journal_title：Vaccine

authors： Bourne N,Milligan GN,Schleiss MR,Bernstein DI,Stanberry LR

更新日期：1996-09-01 00:00:00

abstract：:Tuberculosis (TB) is the second leading cause of death by infectious disease worldwide. The only available TB vaccine is the Bacille Calmette-Guerin (BCG). However, parenterally administered Mycobacterium bovis BCG vaccine confers only limited immune protection from pulmonary tuberculosis in humans. There is a need fo...

journal_title：Vaccine

authors： Shen CF,Jacob D,Zhu T,Bernier A,Shao Z,Yu X,Patel M,Lanthier S,Kamen A

更新日期：2016-06-17 00:00:00

abstract：:A passive immunity test (MPT) in suckling mice for the quantification of protective anti-foot-and-mouth disease virus (FMDV) antibodies in serum is described. Comparisons with titres obtained using conventional serum neutralization tests show that for cattle given synthetic peptide vaccines this in vivo assay is a bet...

journal_title：Vaccine

authors： Mulcahy G,Pullen LA,Gale C,DiMarchi RD,Doel TR

更新日期：1991-01-01 00:00:00

abstract：:We tested a candidate live, oral, rotavirus vaccine (Rotavin-M1™) derived from an attenuated G1P [8] strain (KH0118-2003) isolated from a child in Vietnam. The vaccine was tested first for safety in 29 healthy adults. When deemed safe, it was further tested for safety and immunogenicity in 160 infants (4 groups) aged ...

journal_title：Vaccine

authors： Dang DA,Nguyen VT,Vu DT,Nguyen TH,Nguyen DM,Yuhuan W,Baoming J,Nguyen DH,Le TL,Rotavin-M1 Vaccine Trial Group.

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:We evaluated the safety and immunogenicity of liquid and lyophilized formulations of an investigational trivalent group B streptococcus (GBS) vaccine in non-pregnant women and assessed the formulations' equivalence in terms of serotype-specific immune response. METHODS:This phase II, randomized, comparative...

journal_title：Vaccine

authors： Beran J,Leroux-Roels G,Van Damme P,de Hoon J,Vandermeulen C,Al-Ibrahim M,Johnson C,Peterson J,Baker S,Seidl C,Dreisbach A,Karsten A,Corsaro B,Henry O,Lattanzi M,Bebia Z

更新日期：2020-04-03 00:00:00

abstract：OBJECTIVES:Public health authorities have the resources to conduct efficient immunization reminder interventions to improve vaccine uptake. The objective of this initiative was to design and implement a cost-effective centralized HPV vaccine reminder using New York State Immunization Information System data as one of f...

journal_title：Vaccine

authors： Coley S,Hoefer D,Rausch-Phung E

更新日期：2018-08-06 00:00:00