Preparation and evaluation of antigen/N-trimethylaminoethylmethacrylate chitosan conjugates for nasal immunization.

abstract：:Human adenoviruses (AdVs) have been extensively studied as vectors for gene therapy and vaccination. However, little attention has been paid to AdV vaccine development and treatment. Currently, there is a lack of information concerning the immunogenicity of AdV major capsid proteins. Here, using AdV7 as a model, we co...

journal_title：Vaccine

authors： Hu K,Fu M,Guan X,Zhang D,Deng X,Xiao Y,Chen R,Liu H,Hu Q

更新日期：2018-07-05 00:00:00

abstract：:Young Australian Aboriginal children in remote communities experience very high rates of pneumococcal carriage and otitis media. Prior to introduction of the 7-valent pneumococcal conjugate vaccine (7vPCV, Prevenar), serotype 16F was an important type found in nasal and ear discharge swabs. Since commencement of pneum...

journal_title：Vaccine

authors： Marsh RL,Smith-Vaughan H,Beissbarth J,Hare K,Kennedy M,Wigger C,Mellon G,Stubbs E,Gadil JR,Pettit A,Mackenzie G,Tipakalippa P,Morris PS,Leach AJ

更新日期：2007-03-22 00:00:00

abstract：:Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in about 150,000 individuals in Eurasia, and several hundred cases of hantavirus pulmonary syndrome (HPS) on the American continent annually. There is consequently a need for rapid diagnostics and effective prevention of hantaviral infections. In this stu...

journal_title：Vaccine

authors： Lindkvist M,Lahti K,Lilliehöök B,Holmström A,Ahlm C,Bucht G

更新日期：2007-02-19 00:00:00

abstract：:The ability of bioinformatics to characterize genomic sequences from pathogenic bacteria for prediction of genes that may encode vaccine candidates, e.g. surface localized proteins, has been evaluated. By applying appropriate tools for genomic mining to the published sequence of Haemophilus influenzae Rd genome, it wa...

journal_title：Vaccine

authors： Chakravarti DN,Fiske MJ,Fletcher LD,Zagursky RJ

更新日期：2000-11-08 00:00:00

abstract：:A study of the serological and epidemiological effects of primary immunization with current live attenuated measles vaccine (Hu191) among 503 children aged 6-15 months, was conducted in Jingzhou, Hubei province, China from 1991 to 1998. The results showed that the positive conversion rate of measles IgG was 91.65%, ge...

journal_title：Vaccine

authors： Youwang Y,Ping W,Feng C

更新日期：2001-02-28 00:00:00

abstract：:West Nile virus (WNV) has caused multiple global outbreaks with increased frequency of neuroinvasive disease in recent years. Despite many years of research, there are no licensed therapeutics or vaccines available for human use. One of the major impediments of vaccine development against WNV is the potential enhancem...

journal_title：Vaccine

authors： Lai H,Paul AM,Sun H,He J,Yang M,Bai F,Chen Q

更新日期：2018-03-27 00:00:00

abstract：OBJECTIVE:Evaluating HIV-1 specific T-cell response in African populations is sometimes compromised by extensive virus diversity and paucity of non-clade B reagents. We evaluated whether consensus group M (ConM) peptides could serve as comparable substitutes for detecting immune responses in clade A and clade D HIV-1 i...

journal_title：Vaccine

authors： Mugaba S,Nakiboneka R,Nanyonjo M,Bugembe-Lule D,Kaddu I,Nanteza B,Tweyongyere R,Kaleebu P,Serwanga J

更新日期：2014-06-24 00:00:00

abstract：:Measles transmission has been well documented in healthcare facilities. Healthcare personnel who are unvaccinated and who lack other evidence of measles immunity put themselves and their patients at risk for measles. We conducted a systematic literature review of measles vaccination policies and their implementation i...

journal_title：Vaccine

authors： Fiebelkorn AP,Seward JF,Orenstein WA

更新日期：2014-08-27 00:00:00

abstract：:We investigated the influence of the site of administration of DNA vaccine on the induced immune response. DNA vaccines were administered by electroporation at three different sites: tibial cranial muscle, abdominal skin and ear pinna. Aiming to draw general conclusions about DNA vaccine delivery, we successively used...

journal_title：Vaccine

authors： Vandermeulen G,Vanvarenberg K,De Beuckelaer A,De Koker S,Lambricht L,Uyttenhove C,Reschner A,Vanderplasschen A,Grooten J,Préat V

更新日期：2015-06-22 00:00:00

abstract：:The necessity of avoiding the use of animals in vaccine potency testing has been widely recognized. The repeatability and reproducibility of the Expected Percentage of Protection (EPP) as a serological potency surrogate for A24 Cruzeiro foot-and-mouth disease virus (FMDV) strain was assessed, and compared with the res...

journal_title：Vaccine

authors： Robiolo B,La Torre J,Maradei E,Beascoechea CP,Perez A,Seki C,Smitsaart E,Fondevila N,Palma E,Goris N,De Clercq K,Mattion N

更新日期：2010-08-31 00:00:00

abstract：BACKGROUND:The relative importance of different attitudes in predicting vaccination among healthcare personnel (HCP) is unclear. We hypothesized that HCP who feel at risk without vaccination or say they would regret not getting vaccinated would be more likely to get vaccinated than HCP who do not expect these emotional...

journal_title：Vaccine

authors： Thompson MG,Gaglani MJ,Naleway A,Ball S,Henkle EM,Sokolow LZ,Brennan B,Zhou H,Foster L,Black C,Kennedy ED,Bozeman S,Grohskopf LA,Shay DK

更新日期：2012-05-21 00:00:00

abstract：:Rift Valley fever virus (RVFV), a member of the family Bunyaviridae, causes severe to fatal disease in newborn ruminants, as well as abortions in pregnant animals; both preventable by vaccination. Availability of a challenge model is a pre-requisite for vaccine efficacy trials. Several modes of inoculation with RVFV Z...

journal_title：Vaccine

authors： Weingartl HM,Miller M,Nfon C,Wilson WC

更新日期：2014-04-25 00:00:00

abstract：:During a pertussis epidemic in 2011-2012 the Western Australian (WA) Department of Health implemented a 'cocooning' programme, offering free pertussis-containing vaccine (dTpa) to new parents. We assessed the impact of vaccinating parents with dTpa on the incidence of pertussis infection in newborns. Births in WA duri...

journal_title：Vaccine

authors： Carcione D,Regan AK,Tracey L,Mak DB,Gibbs R,Dowse GK,Bulsara M,Effler PV

更新日期：2015-10-13 00:00:00

abstract：:Peripheral blood mononuclear cells were taken from subjects before and after oral immunization with cholera toxin B-subunit. Cells obtained from naive volunteers before immunization did not proliferate in vitro to B-subunit. Oral immunization induced a proliferative response in all volunteers with a peak stimulation i...

journal_title：Vaccine

authors： Lewis DJ,Castello-Branco LR,Novotny P,Dougan G,Poulton TA,Griffin GE

更新日期：1993-01-01 00:00:00

abstract：:Since preexisting immunity and enhanced infection rates in a clinical trial of an HIV vaccine have raised some concerns on adenovirus (Ad) serotype 5-based vaccines, we evaluated the subgroup D adenovirus serotype Ad19a for its suitability as novel viral vector vaccine against mucosal infections. In BALB/c mice, we co...

journal_title：Vaccine

authors： Lapuente D,Ruzsics Z,Thirion C,Tenbusch M

更新日期：2018-05-03 00:00:00

abstract：:Immune responses to the infectious bronchitis virus (IBV) nucleocapsid protein were studied using a recombinant-DNA expression product. In mice, a lymphocyte proliferative response and a delayed-type hypersensitivity reaction to IBV were induced upon immunization with this nucleocapsid protein. Next, we studied the ro...

journal_title：Vaccine

authors： Boots AM,Benaissa-Trouw BJ,Hesselink W,Rijke E,Schrier C,Hensen EJ

更新日期：1992-01-01 00:00:00

abstract：:To study the kinetics of humoral as well as cellular immunity to measles and to test for associated immunosuppression 124 12 month old children were studied twice, before routine MMR and either 14, 22, 30, or 38 days after vaccination. Plaque reduction neutralization (PRN) titres were determined at these time points a...

journal_title：Vaccine

authors： Pabst HF,Spady DW,Carson MM,Stelfox HT,Beeler JA,Krezolek MP

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Tuberculosis is a major challenge for health care, as options for its treatment and prevention are limited. Therefore, novel approaches, such as DNA vaccination, to both prevent primary infections and the reactivation of latent infections need to be developed. A Mycobacterium marinum infection in adult zebra...

journal_title：Vaccine

authors： Niskanen M,Myllymäki H,Rämet M

更新日期：2020-07-31 00:00:00

abstract：:Cysteine peptidases (CPs) have been implicated in various processes central to the pathogenicity of Leishmania parasites, and are thought to be key factors in the host-parasite interaction. In order to fully evaluate the potential of the CPs as vaccine candidates, studies in natural host species are required. In the s...

journal_title：Vaccine

authors： Poot J,Spreeuwenberg K,Sanderson SJ,Schijns VE,Mottram JC,Coombs GH,Vermeulen AN

更新日期：2006-03-24 00:00:00

abstract：:Dendritic cells (DCs) have been identified as the most effective antigen-presenting cell (APC), much attention has been directed toward the use of DCs in vaccine strategies for the treatment of cancer or chronic virus infection. B7-H1 (PD-L1) is a ligand for programmed cell death-1 (PD-1) and does not bind to other CD...

journal_title：Vaccine

authors： Jiang W

更新日期：2012-01-17 00:00:00

abstract：:Clinical and experimental studies of HIV-1 subcomponents were made in order to increase their immunogenicity. HIV subtype envelopes A, B and C have been compared and a detailed analysis made by peptides of the coreceptor-ligand interactions. We identified a direct interaction between HIV-1 envelope and a cellular rece...

journal_title：Vaccine

authors： Wahren B,Ljungberg K,Rollman E,Levi M,Zuber B,Kjerrström Zuber A,Hinkula J,Leandersson AC,Calarota S,Hejdeman B,Bratt G,Sandström E

更新日期：2002-05-06 00:00:00

abstract：:Heavy chain fragments of botulinum neurotoxin serotypes A and B are being developed as a bivalent vaccine for botulism. To potentiate the immune response, an aluminum containing adjuvant will be formulated with the two antigens. The adsorption mechanisms of each antigen to aluminum phosphate and aluminum hydroxide adj...

journal_title：Vaccine

authors： DePaz RA,Henderson I,Advant SJ

更新日期：2005-07-01 00:00:00

abstract：:Systemic infection by Salmonella typhimurium requires coordinated expression of virulence genes found primarily in Salmonella Pathogenecity Islands (SPIs). We have previously reported that the intracellular signal that induces these virulence genes is a stringent signal molecule, ppGpp [Song et al. J Biol Chem 2003;27...

journal_title：Vaccine

authors： Na HS,Kim HJ,Lee HC,Hong Y,Rhee JH,Choy HE

更新日期：2006-03-15 00:00:00

abstract：:In the present study, we have produced recombinant paraflagellar rod proteins (PFR) and report their use for successful vaccination of mice against Trypanosoma cruzi. This protection is associated with a highly polarized type 1 cytokine production profile. Additionally, we have analyzed the gene sequence encoding PFR-...

journal_title：Vaccine

authors： Luhrs KA,Fouts DL,Manning JE

更新日期：2003-06-20 00:00:00

abstract：:Although a highly effective vaccine against smallpox, vaccinia virus (VV) is not without adverse events, some of which can be life-threatening, particularly in immunocompromised individuals. We have recently demonstrated that the immunogenicity and protective efficacy of Dryvax(®) in immunocompetent mice is preserved ...

journal_title：Vaccine

authors： Berhanu A,King DS,Mosier S,Jordan R,Jones KF,Hruby DE,Grosenbach DW

更新日期：2010-12-16 00:00:00

abstract：:The United States Advisory Committee on Immunization Practices (ACIP) is a federal advisory committee that develops written recommendations for use of vaccines licensed by the Food and Drug Administration (FDA) for the U.S. civilian population. Vaccine development and disease outbreaks contributed to the need for a sy...

journal_title：Vaccine

authors： Walton LR,Orenstein WA,Pickering LK

更新日期：2015-01-09 00:00:00

abstract：:Two hundred and fifty children born in 1967 and vaccinated with killed polio vaccine in Sweden were followed for 18 years and tested for neutralizing antibodies against polio. All of them had demonstrable antibodies at the age of 18. Sixty-four children were tested in samples collected throughout the years. After a mo...

journal_title：Vaccine

authors： Böttiger M

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:As part of the U.S. Department of Health and Human Services (HHS) Pandemic Influenza Plan preparedness and response strategy, the National Pre-Pandemic Influenza Vaccine Stockpile (NPIVS) program was established by the Biomedical Advanced Research and Development Authority (BARDA) in 2005 with the goal of bu...

journal_title：Vaccine

authors： Oshansky CM,Zhou J,Gao Y,Schweinle JE,Biscardi K,DeBeauchamp J,Pavetto C,Wollish A,BRITE Study Coordination Team.,Webby RJ,Cioce V,Donis RO,Bright RA

更新日期：2019-01-14 00:00:00

abstract：:On July 9, 2014, Aeras and the Max Planck Institute for Infection Biology convened a workshop entitled "Whole Mycobacteria Cell Vaccines for Tuberculosis" at the Max Planck Institute for Infection Biology on the grounds of the Charité Hospital in Berlin, Germany, close to the laboratory where, in 1882, Robert Koch fir...

journal_title：Vaccine

authors： Whole Mycobacteria Cell Vaccines for Tuberculosis Summary Group.

更新日期：2015-06-12 00:00:00

abstract：:Rotavirus (RV) is the primary etiologic agent of severe gastroenteritis in human infants. Although two attenuated RV-based vaccines have been licensed to be applied worldwide, they are not so effective in low-income countries, and the induced protection mechanisms have not been clearly established. Thus, it is importa...

journal_title：Vaccine

authors： Badillo-Godinez O,Gutierrez-Xicotencatl L,Plett-Torres T,Pedroza-Saavedra A,Gonzalez-Jaimes A,Chihu-Amparan L,Maldonado-Gama M,Espino-Solis G,Bonifaz LC,Esquivel-Guadarrama F

更新日期：2015-08-20 00:00:00