Abstract：
:In the present study, we have produced recombinant paraflagellar rod proteins (PFR) and report their use for successful vaccination of mice against Trypanosoma cruzi. This protection is associated with a highly polarized type 1 cytokine production profile. Additionally, we have analyzed the gene sequence encoding PFR-2 to determine the degree of conservation among seven highly diverse strains of T. cruzi, and found it to be highly conserved. The results presented here indicate that the PFR antigens are highly conserved, and immunization with rPFR-1, PFR-2, or an equimolar mix of the PFR-1, -2, and -3 proteins provides protective immunity against Trypanosoma cruzi.
journal_name
Vaccinejournal_title
Vaccineauthors
Luhrs KA,Fouts DL,Manning JEdoi
10.1016/s0264-410x(03)00108-7subject
Has Abstractpub_date
2003-06-20 00:00:00pages
3058-69issue
21-22eissn
0264-410Xissn
1873-2518pii
S0264410X03001087journal_volume
21pub_type
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