Immunization with recombinant paraflagellar rod protein induces protective immunity against Trypanosoma cruzi infection.

Abstract:

:In the present study, we have produced recombinant paraflagellar rod proteins (PFR) and report their use for successful vaccination of mice against Trypanosoma cruzi. This protection is associated with a highly polarized type 1 cytokine production profile. Additionally, we have analyzed the gene sequence encoding PFR-2 to determine the degree of conservation among seven highly diverse strains of T. cruzi, and found it to be highly conserved. The results presented here indicate that the PFR antigens are highly conserved, and immunization with rPFR-1, PFR-2, or an equimolar mix of the PFR-1, -2, and -3 proteins provides protective immunity against Trypanosoma cruzi.

journal_name

Vaccine

journal_title

Vaccine

authors

Luhrs KA,Fouts DL,Manning JE

doi

10.1016/s0264-410x(03)00108-7

subject

Has Abstract

pub_date

2003-06-20 00:00:00

pages

3058-69

issue

21-22

eissn

0264-410X

issn

1873-2518

pii

S0264410X03001087

journal_volume

21

pub_type

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