Abstract：
:Systemic infection by Salmonella typhimurium requires coordinated expression of virulence genes found primarily in Salmonella Pathogenecity Islands (SPIs). We have previously reported that the intracellular signal that induces these virulence genes is a stringent signal molecule, ppGpp [Song et al. J Biol Chem 2003;279:34183]. In this study, we found that relA and spoT double mutant Salmonella (DeltappGpp strain), which is defective in ppGpp synthesis, was virtually avirulent in BALB/c mice. Subsequently, the live vaccine potential of the avirulent DeltappGpp Salmonella strain was determined. A single immunization with live DeltappGpp Salmonella efficiently protected mice from challenge with wild-type Salmonella at a dose 10(6)-fold above the LD50 30 days after immunization. Various assays revealed that immunization of mice with the DeltappGpp strain elicited both systemic and mucosal antibody responses, in addition to cell-mediated immunity.
journal_name
Vaccinejournal_title
Vaccineauthors
Na HS,Kim HJ,Lee HC,Hong Y,Rhee JH,Choy HEdoi
10.1016/j.vaccine.2005.11.031subject
Has Abstractpub_date
2006-03-15 00:00:00pages
2027-34issue
12eissn
0264-410Xissn
1873-2518pii
S0264-410X(05)01174-6journal_volume
24pub_type
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