Abstract:
:HL1 gene encoding haemolysin from Vibrio harveyi SF-1 was expressed in yeast cells and the expressed haemolysin was displayed on the cell surface. After induction for 36h in galactose-containing medium, one-third of the cells contained the displayed protein and the displayed cells had haemolytic activity on erythrocytes from flounder. The double diffusion agar analysis showed that the sera from the flounder immunized with the displayed yeast cells having the haemolytic activity could form precipitate with the purified haemolysin. ELISA analysis indicated that immunization times had great influence on increased production of the specific antibody against haemolysin in turbot immunized with the displayed yeast cells having the haemolytic activity. After the challenge with V. harveyi SF-1, it was found that earlier protection in flounder and significant protection in turbot, both of which were immunized with the displayed yeast cells having the haemolytic activity, were achieved. These results suggested that the displayed yeast cells with the haemolytic activity could be used as potential live vaccine in marine fish.
journal_name
Vaccinejournal_title
Vaccineauthors
Zhu K,Chi Z,Li J,Zhang F,Li M,Yasoda HN,Wu Ldoi
10.1016/j.vaccine.2006.05.043subject
Has Abstractpub_date
2006-08-28 00:00:00pages
6046-52issue
35-36eissn
0264-410Xissn
1873-2518pii
S0264-410X(06)00578-0journal_volume
24pub_type
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