Induction of anti-viral immune responses by immunization with recombinant-DNA encoded avian coronavirus nucleocapsid protein.

abstract：:Vaccination during pregnancy is increasingly being used as an effective approach for protecting both young infants and their mothers from serious infections. Drawing conclusions from published studies in this area can be difficult because of the inability to compare vaccine trial results across different studies and s...

journal_title：Vaccine

authors： Jones CE,Munoz FM,Spiegel HM,Heininger U,Zuber PL,Edwards KM,Lambach P,Neels P,Kohl KS,Gidudu J,Hirschfeld S,Oleske JM,Khuri-Bulos N,Bauwens J,Eckert LO,Kochhar S,Bonhoeffer J,Heath PT,Brighton Collaboration Immunizat

更新日期：2016-12-01 00:00:00

abstract：:In this paper we give guidance for the design and conduct of vaccine trials against Plasmodium vivax malaria. The paper supplements earlier guidelines on the planning of vaccine trials against Plasmodium falciparum malaria [WHO. Guidelines for the evaluation of Plasmodium falciparum vaccines in populations exposed to ...

journal_title：Vaccine

authors： Mueller I,Moorthy VS,Brown GV,Smith PG,Alonso P,Genton B,WHO Malaria Vaccine Advisory Committee (MALVAC).

更新日期：2009-09-18 00:00:00

abstract：:Enterotoxigenic E. coli (ETEC) and Shigella are enteropathogens causing significant global morbidity and mortality, particularly in low-income countries. No licensed vaccine exists for either pathogen, but candidates are in development, with the most advanced candidates potentially approaching pivotal efficacy testing...

journal_title：Vaccine

authors： Hosangadi D,Smith PG,Giersing BK

更新日期：2019-11-28 00:00:00

abstract：:Development of a safe and effective vaccine against human immunodeficiency virus (HIV) is urgent, but many concerns regarding the safety and efficacy of the currently developing vaccines remain. A major hindrance in HIV vaccine development is the genetic diversity, a hallmark of HIV biology, and a poor understanding o...

journal_title：Vaccine

authors： Mukai T,Kurosu T,Kinomoto M,Komoto S,Shiraga M,Auwanit W,Ikuta K

更新日期：2002-01-15 00:00:00

abstract：:Polymeric nanoparticles (NPs) of poly (lactic-co-glycolic) acid (PLGA) possess adjuvant properties. To date, there are few studies exploring their application as antigen carriers for vaccination of fish. This study presents a preclinical assessment of the early innate and adaptive immune responses in Atlantic salmon f...

journal_title：Vaccine

authors： Fredriksen BN,Sævareid K,McAuley L,Lane ME,Bøgwald J,Dalmo RA

更新日期：2011-10-26 00:00:00

abstract：:A newly developed human diploid cell rabies vaccine (Lyssavac-HDC), produced without added serum albumin and with an effort to remove the virus-inactivating beta-propriolactone prior to addition of the gelatin, L-cysteine and potassium phosphate stabilizer, was tested for safety immunogenicity, adverse reactions and e...

journal_title：Vaccine

authors： Wilde H,Glueck R,Khawplod P,Cryz SJ,Tantawichien T,Thipkong P,Chomchey P,Prakongsri S,Benjavongkulchai M,Sumboonanondha A

更新日期：1995-04-01 00:00:00

abstract：:The ribosomes from BCG strongly induced delayed type hypersensitivity (DTH) skin reactions in guinea pigs immunized with live BCG or heat killed Mycobacterium tuberculosis H37Rv, and also induced lymphocyte proliferative response in mice immunized with ribosomes. In contrast, neither ribosomal proteins nor RNA alone i...

journal_title：Vaccine

authors： Miyazaki C,Ohara N,Yukitake H,Kinomoto M,Matsushita K,Matsumoto S,Mizuno A,Yamada T

更新日期：1999-01-21 00:00:00

abstract：BACKGROUND:Inactivated quadrivalent influenza vaccine (IIV4) containing two influenza A strains and one strain from each B lineage (Yamagata and Victoria) may offer broader protection against seasonal influenza than inactivated trivalent influenza vaccine (IIV3), containing a single B strain. This study examined the sa...

journal_title：Vaccine

authors： Cadorna-Carlos JB,Nolan T,Borja-Tabora CF,Santos J,Montalban MC,de Looze FJ,Eizenberg P,Hall S,Dupuy M,Hutagalung Y,Pépin S,Saville M

更新日期：2015-05-15 00:00:00

abstract：:We successfully re-vaccinated hepatitis B virus (HBV) vaccine non-responders using a double dose of the combined hepatitis A virus (HAV) and HBV vaccine. The hope was to improve priming of hepatitis B surface antigen (HBsAg)-specific cell mediated immune response (CMI) by an increased antigen dose and a theoretical ad...

journal_title：Vaccine

authors： Nyström J,Cardell K,Björnsdottir TB,Fryden A,Hultgren C,Sällberg M

更新日期：2008-11-05 00:00:00

abstract：:A hospital-based case-control study was carried out at the Vilela Children's Hospital in Rosario, Argentina, to measure the protection conferred by BCG vaccination against tuberculosis (TB). The study included 148 newly diagnosed cases of TB (75 males and 73 females, mean age 3.34+/-2.97 years, S.D.), 134 of them with...

journal_title：Vaccine

authors： Bonifachich E,Chort M,Astigarraga A,Diaz N,Brunet B,Pezzotto SM,Bottasso O

更新日期：2006-04-05 00:00:00

abstract：:Human botulism is commonly associated with botulinum neurotoxin (BoNT) serotypes A, B, E and F. This suggests that the greatest need is for a tetravalent vaccine that provides protection against all four of these serotypes. In current study, we investigated the feasibility of generating several tetravalent vaccines th...

journal_title：Vaccine

authors： Yu YZ,Guo JP,An HJ,Zhang SM,Wang S,Yu WY,Sun ZW

更新日期：2013-05-07 00:00:00

abstract：:Infection with influenza virus during pregnancy poses a significant risk of complications for both mother and fetus. During the H1N1 2009 pandemic, pregnant women constituted one of the priority groups for vaccination in many countries, creating a need for close monitoring of the safety of the vaccine in pregnant wome...

journal_title：Vaccine

authors： Tavares F,Nazareth I,Monegal JS,Kolte I,Verstraeten T,Bauchau V

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:The recently developed test-negative design is now standard for observational studies of influenza vaccine effectiveness (VE). It is unclear how influenza test misclassification biases test-negative VE estimates relative to VE estimates from traditional cohort or case-control studies. METHODS:We simulated p...

journal_title：Vaccine

authors： Jackson ML,Rothman KJ

更新日期：2015-03-10 00:00:00

abstract：:Human papillomavirus (HPV)-related morbidity and mortality from cervical cancer primarily occurs in the developing world, where, unfortunately, access to vaccines in general, and expensive newer vaccines in particular, is often more limited than in the industrialized world. In addition, secondary prevention methods su...

journal_title：Vaccine

authors： Kane MA,Sherris J,Coursaget P,Aguado T,Cutts F

更新日期：2006-08-31 00:00:00

abstract：:The PEDVAC study is the first trial designed to analyze safety and immunogenicity of a therapeutic vaccination with a multiclade multigene HIV DNA vaccine (HIVIS) in infected children. Twenty HIV-1 vertically infected children (6-16 years of age), on stable antiretroviral treatment for at least 6 months with HIV-1 RNA...

journal_title：Vaccine

authors： Palma P,Romiti ML,Li Pira G,Montesano C,Mora N,Aquilani A,Santilli V,Tchidjou HK,Ivaldi F,Giovannelli L,Pontrelli G,Borra G,Blomberg P,Gudmundsdotter L,Bråve A,Montano M,Bernardi S,Manca F,Wahren B,Rossi P

更新日期：2011-09-09 00:00:00

abstract：BACKGROUND:US-bound refugees undergo required health assessments overseas to identify and treat communicable diseases of public health significance-such as pulmonary tuberculosis-before migration. Immunizations are not required, leaving refugees at risk for vaccine-preventable diseases. In response, the US Centers for ...

journal_title：Vaccine

authors： Mitchell T,Dalal W,Klosovsky A,Yen C,Phares C,Burkhardt M,Amin F,Froes I,Hamadeh A,Lynn SA,Quintanilla J,Doney AC,Cetron M,Weinberg M

更新日期：2021-01-03 00:00:00

abstract：:Plague is a zoonotic disease caused by Yersinia pestis, an etiological agent of pneumonic and bubonic plague. There is a need for an improved plague vaccine that may overcome the limitation of presently available whole cell vaccine. An alternative approach described here, is the use of protective epitopes from immunod...

journal_title：Vaccine

authors： Tripathi V,Chitralekha KT,Bakshi AR,Tomar D,Deshmukh RA,Baig MA,Rao DN

更新日期：2006-04-12 00:00:00

abstract：:Fish has a soluble form of TLR5 ortholog (TLR5S), which does not exist in mammals. We identified TLR5S from rainbow trout and named rtTLR5S, which was about 38% homologous to the extracellular domains of human (hu) and mouse TLR5. Adjuvancy of rtTLR5S to flagellin response by human TLR5 (huTLR5) was tested in this stu...

journal_title：Vaccine

authors： Tsujita T,Ishii A,Tsukada H,Matsumoto M,Che FS,Seya T

更新日期：2006-03-15 00:00:00

abstract：:Currently, infections of hand, foot and mouth disease (HFMD) due to Human Enterovirus 71 (EV71) cannot be prevented or treated, as there are no suitable vaccines or antiviral drugs. This study aimed to identify potential vaccine candidates for EV71 using in silico analysis of its viral capsid proteins. A combined in s...

journal_title：Vaccine

authors： Kirk K,Poh CL,Fecondo J,Pourianfar H,Shaw J,Grollo L

更新日期：2012-11-19 00:00:00

abstract：OBJECTIVE:The objectives of this review were to identify vaccine economic evaluations that include herd immunity and describe the methodological approaches used. METHODS:We used Kim and Goldie's search strategy from a systematic review (1976-2007) of modelling approaches used in vaccine economic evaluations and additi...

journal_title：Vaccine

authors： Nymark LS,Sharma T,Miller A,Enemark U,Griffiths UK

更新日期：2017-12-14 00:00:00

abstract：:New and improved vaccines and delivery systems are increasingly being developed for prevention, treatment and diagnosis of human diseases. Prior to their use in humans, all new biological products must undergo pre-clinical evaluation. These pre-clinical studies are important not only to establish the biological proper...

journal_title：Vaccine

authors： Sesardic D

更新日期：2006-04-12 00:00:00

abstract：:Porcine circovirus type-2b (PCV2b) is the primary global causative agent of porcine circovirus-associated disease (PCVAD). In this study, we first constructed a novel chimeric virus (PCV1-2b) with the PCV2b capsid gene cloned into the backbone of non-pathogenic PCV1. A pathogenicity study conducted in caesarean-derive...

journal_title：Vaccine

authors： Beach NM,Ramamoorthy S,Opriessnig T,Wu SQ,Meng XJ

更新日期：2010-12-16 00:00:00

abstract：:Attenuated strains of Salmonella have been used as vaccines to deliver heterologous antigens mainly to generate a humoral immune response. However, little is known about their ability to induce a cell-mediated immune response to the T-cell epitopes of another infectious agent or how optimally to deliver these epitopes...

journal_title：Vaccine

authors： Verma NK,Ziegler HK,Stocker BA,Schoolnik GK

更新日期：1995-02-01 00:00:00

abstract：:For infants immunized with Haemophilus influenzae type b conjugate vaccines, booster immunization is usually recommended in the second year of life, typically between 12 and 18 months. This study assessed the effect of age at booster immunization on pre-immunization antibody trough levels and on subsequent responses, ...

journal_title：Vaccine

authors： Scheifele DW,Guasparini R,Lavigne P

更新日期：1999-02-12 00:00:00

abstract：:The need for developing a case definition and guidelines for a local reaction at or near the injection site, methods for the development of the case definition and guidelines as an adverse event following immunization as well as the rationale for selected decisions about the case definition for a local reaction at or ...

journal_title：Vaccine

authors： Gidudu J,Kohl KS,Halperin S,Hammer SJ,Heath PT,Hennig R,Hoet B,Rothstein E,Schuind A,Varricchio F,Walop W,Brighton Collaboration Local Reactions Working Group for a Local Reaction at or near Injection Site.

更新日期：2008-12-09 00:00:00

abstract：:To evaluate the perceived pain, other adverse events, and immunogenicity of influenza virus vaccine administered by needle-free jet injector (JI) compared with that of vaccine administered by needle and syringe (N&S), we randomly assigned 304 healthy young adults to receive one of three dosages (0.5, 0.3, or 0.2 ml) o...

journal_title：Vaccine

authors： Jackson LA,Austin G,Chen RT,Stout R,DeStefano F,Gorse GJ,Newman FK,Yu O,Weniger BG,Vaccine Safety Datalink Study Group.

更新日期：2001-09-14 00:00:00

abstract：:Enterotoxigenic E. coli (ETEC) are an important cause of diarrhea in developing countries, especially among indigenous children and travelers. In this randomized, double-blind, placebo-controlled trial, a live, attenuated CS1/CS3 ETEC strain, PTL-003, was tested as a potential vaccine strain. Thirty-three subjects dra...

journal_title：Vaccine

authors： McKenzie R,Darsley M,Thomas N,Randall R,Carpenter C,Forbes E,Finucane M,Sack RB,Hall E,Bourgeois AL

更新日期：2008-08-26 00:00:00

abstract：:On July 9, 2014, Aeras and the Max Planck Institute for Infection Biology convened a workshop entitled "Whole Mycobacteria Cell Vaccines for Tuberculosis" at the Max Planck Institute for Infection Biology on the grounds of the Charité Hospital in Berlin, Germany, close to the laboratory where, in 1882, Robert Koch fir...

journal_title：Vaccine

authors： Whole Mycobacteria Cell Vaccines for Tuberculosis Summary Group.

更新日期：2015-06-12 00:00:00

abstract：:Since 1996, the scientific community has become aware of 14 reports of yellow fever vaccine (YEL)-associated viscerotropic disease (YEL-AVD) cases and four reports of YEL-associated neurotropic disease (YEL-AND) worldwide, changing our understanding of the risks of the vaccine. Based on 722 adverse event reports after...

journal_title：Vaccine

authors： Khromava AY,Eidex RB,Weld LH,Kohl KS,Bradshaw RD,Chen RT,Cetron MS,Yellow Fever Vaccine Safety Working Group.

更新日期：2005-05-09 00:00:00

abstract：BACKGROUND:Although guidelines for prophylactic human papillomavirus (HPV) vaccination recommend two doses for girls ages 9-14 years, several studies have demonstrated similar protection with one dose. Our objective was to evaluate the long-term health and economic impacts of routine one-dose HPV vaccination compared t...

journal_title：Vaccine

authors： Burger EA,Campos NG,Sy S,Regan C,Kim JJ

更新日期：2018-08-06 00:00:00