The site of administration influences both the type and the magnitude of the immune response induced by DNA vaccine electroporation.

abstract：:Nasal administration of vaccines is an attractive approach which offers several significant advantages over traditional intramuscular vaccine delivery. These advantages include easier administration and induction of immune responses in the mucosal secretions of the body. In this study we describe a new potent nasal ad...

journal_title：Vaccine

authors： Klinguer C,Beck A,De-Lys P,Bussat MC,Blaecke A,Derouet F,Bonnefoy JY,Nguyen TN,Corvaïa N,Velin D

更新日期：2001-07-20 00:00:00

abstract：:The neutralising antibody response after the yellow fever vaccine (YF-17D) skin test was measured in 7 egg allergic persons in whom further vaccination was abandoned because of a strong local urticarial reaction to the YF-17D vaccine test dose. We found that this test dose of 0.1mL of YF-17D vaccine was sufficient to ...

journal_title：Vaccine

authors： Roukens AH,Vossen AC,van Dissel JT,Visser LG

更新日期：2009-04-21 00:00:00

abstract：:Routine administration of the quadrivalent human papillomavirus (HPV) vaccine has been recommended for 11-12-year-old males since 2011, but coverage remains low. In a U.S. national sample of parents of 11-17-year-old males (n=779), 78.6% of parents reported their sons had not received the HPV vaccine. The most common ...

journal_title：Vaccine

authors： Donahue KL,Stupiansky NW,Alexander AB,Zimet GD

更新日期：2014-06-30 00:00:00

abstract：:In this investigation we have generated and defined the immunogenicity of two novel HIV/AIDS vaccine candidates based on the highly attenuated vaccinia virus strains, MVA and NYVAC, efficiently expressing in the same locus (TK) and under the same viral promoter the codon optimized HIV-1 genes encoding gp120 and Gag-Po...

journal_title：Vaccine

authors： Gómez CE,Nájera JL,Jiménez EP,Jiménez V,Wagner R,Graf M,Frachette MJ,Liljeström P,Pantaleo G,Esteban M

更新日期：2007-04-12 00:00:00

abstract：:Lactobacillus spp. comprise a large group of Gram-positive lactic acid bacteria with varying physiological, ecological and immunomodulatory properties that are widely exploited by mankind, primarily in food production and as health-promoting probiotics. Recent years have shown increased interest in using lactobacilli ...

journal_title：Vaccine

authors： Kuczkowska K,Øverland L,Rocha SDC,Eijsink VGH,Mathiesen G

更新日期：2019-10-08 00:00:00

abstract：UNLABELLED:In low-income countries early measles vaccine (MV) is associated with reduced child mortality which cannot be explained by prevention of measles. A large thymus gland in infancy is also associated with reduced mortality. We hypothesized that early MV is associated with increased thymic size. Within a randomi...

journal_title：Vaccine

authors： Christensen LD,Eriksen HB,Biering-Sørensen S,Balé C,Do VA,Andersen A,Martins CL,Sodemann M,Aaby P,Benn CS

更新日期：2014-03-26 00:00:00

abstract：BACKGROUND:Adolescent HPV vaccination in minority and low income populations with high cervical cancer incidence and mortality could reduce disparities. Safety-net primary care clinics are a key delivery site for improving vaccination rates in these populations. PURPOSE:To examine prevalence of HPV initiation (≥ 1 dos...

journal_title：Vaccine

authors： Tiro JA,Pruitt SL,Bruce CM,Persaud D,Lau M,Vernon SW,Morrow J,Skinner CS

更新日期：2012-03-16 00:00:00

abstract：:In this review we aim to provide the reader with an understanding of the capsular-based complexity of Streptococcus pneumoniae, one of the main limitations to current vaccine development. We then discuss the need for a new vaccine strategy based on proteic antigen candidates discovered in silico. Describing specifical...

journal_title：Vaccine

authors： Barocchi MA,Censini S,Rappuoli R

更新日期：2007-04-20 00:00:00

abstract：:Influenza causes considerable morbidity and mortality and the damage to public health can be considerable. The most effective measures available for the prevention of influenza is vaccination. In most industrialised countries the objective of vaccination is to limit the disease among individuals at risk, especially th...

journal_title：Vaccine

authors： Gasparini R,Lucioni C,Lai P,Maggioni P,Sticchi L,Durando P,Morelli P,Comino I,Calderisi S,Crovari P

更新日期：2002-12-20 00:00:00

abstract：:Vaccination with viral-based vaccines continues to hold promise for the prevention of malaria. Whilst antigen-specific T cell responses are considered a major aim of such an approach, a role for induced NK cells as anti-malarial effector cells, or in shaping T cell responses, has received less attention. In this study...

journal_title：Vaccine

authors： Berthoud TK,Fletcher H,Porter D,Thompson F,Hill AV,Todryk SM

更新日期：2009-12-10 00:00:00

abstract：BACKGROUND:Pseudotuberculosis is an infection caused by the bacterial enteropathogen Yersinia pseudotuberculosis and is considered to be a significant problem in veterinary medicine. We previously found that intranasal administration of a recombinant Lactococcus lactis strain that secretes the low-calcium response V (L...

journal_title：Vaccine

authors： Daniel C,Titecat M,Poiret S,Cayet D,Boutillier D,Simonet M,Sirard JC,Lemaître N,Sebbane F

更新日期：2016-11-11 00:00:00

abstract：:Fasciolosis continues to be a major cause of economic losses in the livestock industry and a growing threat to humans. The limited spectrum of effective anthelmintics and the appearance of resistances urge the need for developing an effective vaccine. Most studies have been focused on the use of TH1-polarizing adjuvan...

journal_title：Vaccine

authors： Orbegozo-Medina RA,Martínez-Sernández V,González-Warleta M,Castro-Hermida JA,Mezo M,Ubeira FM

更新日期：2018-04-05 00:00:00

abstract：:Bovine mastitis is responsible of major economic losses on dairy farms worldwide. In Argentine dairy herds, Staphylococcus aureus is the main causative agent of the disease. The ineffectiveness of some current practices to control S. aureus infections, often leads to a chronic and recurrent infection with persistent b...

journal_title：Vaccine

authors： Pellegrino M,Giraudo J,Raspanti C,Odierno L,Bogni C

更新日期：2010-06-17 00:00:00

abstract：CONTEXT:The true level of influenza vaccine efficacy is controversial and many factors may influence its estimation. OBJECTIVES:To estimate the efficacy of vaccination of children and non-elderly adults for the prevention of influenza and to explore the impact of type of vaccine, age, degree of strain matching, influe...

journal_title：Vaccine

authors： DiazGranados CA,Denis M,Plotkin S

更新日期：2012-12-17 00:00:00

abstract：:The level of antibody production induced by a vaccine involves a variety of host factors. One of these, insulin-like growth factor-1 (IGF-1), plays an important role in lymphocyte maturation and antibody expression. Here, we investigated the role of macrophage-derived IGF-1 in the induction of influenza vaccine-specif...

journal_title：Vaccine

authors： Yoon IS,Park H,Kwak HW,Woo Jung Y,Nam JH

更新日期：2017-08-24 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) is the etiological agent of a highly contagious disease that affects cloven-hoofed animal species. The FMDV capsid is highly acid labile and viral particles lose their immunogenicity when they disassemble at mildly acidic pHs. The viral capsid of FMDV serotype O is more sensitive th...

journal_title：Vaccine

authors： Xie Y,Li H,Qi X,Ma Y,Yang B,Zhang S,Chang H,Yin X,Li Z

更新日期：2019-03-28 00:00:00

abstract：:Domestic dogs constitute the main reservoir of Leishmania infantum and play a key role in transmission to humans. The main tool for controlling infection spread is a safe and effective vaccine, as successful immunization of dogs could significantly reduce the incidence of human visceral leishmaniosis (VL) and is the m...

journal_title：Vaccine

authors： Cacheiro-Llaguno C,Parody N,Renshaw-Calderón A,Osuna C,Alonso C,Carnés J

更新日期：2020-01-22 00:00:00

abstract：:Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, a highly contagious and often fatal disease. We have previously reported the construction and characterization of a single gene apxIIC deletion mutant HB04C(-) based on A. pleuropneumoniae serovar 7 which produces ApxII toxin and ApxIV....

journal_title：Vaccine

authors： Liu J,Chen X,Lin L,Tan C,Chen Y,Guo Y,Jin M,Guo A,Bei W,Chen H

更新日期：2007-11-01 00:00:00

abstract：:This study was aimed to evaluate the efficacy and immunogenicity of combined hepatitis B vaccination with plasma-derived vaccine (PDV) and recombinant vaccine (RV). A total of 329 infants was recruited, including 224 high-risk infants born to hepatitis B e antigen-positive mothers and 105 low-risk infants born to hepa...

journal_title：Vaccine

authors： Lee PI,Lee CY,Huang LM,Chen JM,Chang MH

更新日期：1995-12-01 00:00:00

abstract：:The ELISA method was used to titrate the humoral immune response in vaccinated mice. When mice were given two doses of a heat-killed salmonella vaccine 6 days apart, there was a steady but low-level increase of antibody synthesis. In contrast, if a booster vaccination was administered 21 days after the primary inocula...

journal_title：Vaccine

authors： Xu HR,Hsu HS,Moncure CW,King RA

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Non-typhoid Salmonella (NTS) is a leading cause of food-borne illness with more than 90 million annual cases and an emerging antimicrobial resistance among the strains worldwide. Paradoxically, no vaccines are available against these pathogens. Numerous NTS strains share surface O-antigens with Salmonella en...

journal_title：Vaccine

authors： Kantele A,Pakkanen SH,Siitonen A,Karttunen R,Kantele JM

更新日期：2012-11-26 00:00:00

abstract：:Recombinant canarypox (CP) and fowlpox (FP) viruses that contained two forms of the HIV-1 (SF2 strain) env gene were engineered and their expression analysed in chick, simian and human cells. These vectors can efficiently replicate in avian but not in mammalian cells, in which infection is abortive. The two forms, con...

journal_title：Vaccine

authors： Radaelli A,De Giuli Morghen C

更新日期：1994-09-01 00:00:00

abstract：:Antigens protective against Ixodes scapularis infestations were identified by cDNA expression library immunization (ELI) and analysis of expressed sequenced tags (EST). Three cDNAs protective against larval tick infestations, 4F8, with homology to a nucleotidase, and 4D8 and 4E6 of unknown function, were characterized...

journal_title：Vaccine

authors： Almazán C,Kocan KM,Blouin EF,de la Fuente J

更新日期：2005-11-16 00:00:00

abstract：:A cost-effectiveness analysis of the introduction of acellular pertussis booster doses at either 4 or 15 years of age was performed. A transmission dynamic model was used to predict the level of indirect protection in those too young to be vaccinated. Multivariate sensitivity analyses were performed. In England and Wa...

journal_title：Vaccine

authors： Edmunds WJ,Brisson M,Melegaro A,Gay NJ

更新日期：2002-01-31 00:00:00

abstract：:Meningococci bind human fH to down-regulate complement, which enhances survival of the bacteria in serum. A major fH ligand is the vaccine candidate, factor H-binding protein (fHbp). Although fHbp has been considered an essential meningococcal virulence factor, rarely, invasive isolates with absent fHbp genes or frame...

journal_title：Vaccine

authors： Giuntini S,Vu DM,Granoff DM

更新日期：2013-08-28 00:00:00

abstract：BACKGROUND:Diabetes is associated with higher risk of hospitalization, morbidity, and mortality from influenza. We assessed influenza vaccination coverage among adults aged ≥ 18 years with diabetes during the 2007-08 through 2017-18 influenza seasons and identified factors independently associated with vaccination duri...

journal_title：Vaccine

authors： Hung MC,Lu PJ,Srivastav A,Cheng YJ,Williams WW

更新日期：2020-09-29 00:00:00

abstract：:Vaccine induced responses are often weaker in those individuals most susceptible to infection, namely the very young and the elderly, highlighting the need for safe and effective vaccine adjuvants. Herein we evaluated different archaeosome formulations as an adjuvant to the H1N1 influenza hemagglutinin protein and com...

journal_title：Vaccine

authors： Stark FC,Akache B,Ponce A,Dudani R,Deschatelets L,Jia Y,Sauvageau J,Williams D,Jamshidi MP,Agbayani G,Wachholz K,Harrison BA,Li X,Krishnan L,Chen W,McCluskie MJ

更新日期：2019-11-08 00:00:00

abstract：:Pertussis incidence in Piemonte (Italy) is now at the lowest level ever reached (0.85 per 100,000 in 2010) but the disease is still endemic in infants (54 per 100,000 in 2005-2010). Parental "cocoon" immunization has been proposed in some countries (i.e. United States, France) as a measure to protect newborns from ser...

journal_title：Vaccine

authors： Meregaglia M,Ferrara L,Melegaro A,Demicheli V

更新日期：2013-02-06 00:00:00

abstract：:Using a fixed dose of antigen, the immune response to detoxified mutants of LT-WT following intranasal (i.n.), subcutaneous (s.c.) and oral (i.g.) immunisation has been studied. When given i.n., both LT-WT and mutant toxin, K63, generated significant levels of toxin-specific IgG in the serum, and the levels of IgA in ...

journal_title：Vaccine

authors： Douce G,Giuliani MM,Giannelli V,Pizza MG,Rappuoli R,Dougan G

更新日期：1998-07-01 00:00:00

abstract：:The adenylate cyclase (CyaA) produced by Bordetella pertussis is able to deliver CD8+ and CD4+ T-cell epitopes genetically grafted within the catalytic domain of the molecule into antigen presenting cells in vivo. We develop now a new approach in which peptides containing CD8+ epitopes are chemically linked to CyaA. W...

journal_title：Vaccine

authors： Fayolle C,Bauche C,Ladant D,Leclerc C

更新日期：2004-12-16 00:00:00