Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media.

Abstract:

BACKGROUND:The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children. METHODS:Open trial in which the intervention group (64 children) received OPV at the age of 2, 3, 6 and 12 months. The control group (250 children) received IPV (inactivated polio vaccine) at the age of 6 and 12 months. Clinical symptoms were recorded by a questionnaire at the age of 3, 6, 12, 18 and 24 months. RESULTS:Otitis media episodes were less frequent in the OPV than in the control group. A significant difference was seen at the age of 6-18 months (IRR=0.76 [95% CI 0.59-0.94], P=0.011) and was particularly clear among children, who attended daycare (IRR 0.37 [95% CI 0.19-0.71], P=0.003). CONCLUSIONS:OPV provides some protection against otitis media. This effect may be mediated by viral interference with non-polio viruses.

journal_name

Vaccine

journal_title

Vaccine

authors

Seppälä E,Viskari H,Hoppu S,Honkanen H,Huhtala H,Simell O,Ilonen J,Knip M,Hyöty H

doi

10.1016/j.vaccine.2011.09.015

subject

Has Abstract

pub_date

2011-11-03 00:00:00

pages

8615-8

issue

47

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(11)01421-6

journal_volume

29

pub_type

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