Pandemic preparedness: different perspectives. How ready are we for the next pandemic?


:Europe is not ready for the next pandemic. Nonetheless, several positive developments are cause for optimism. The European Centre for Disease Control (ECDC) was founded in May 2005 and has explicitly identified influenza as one of its top four priorities. Europe is also taking steps to streamline the regulatory approval of new vaccines during a pandemic. Europe can learn much from Canada. The Canadian public health authorities have focused on developing the infrastructure, procedures and acceptance for vaccination against the annual influenza epidemics as a means of strengthening pandemic preparedness. The Canadians are also stockpiling antiviral drugs. These drugs are an excellent way to bridge the gap between the appearance of a pandemic virus and the development of an effective vaccine against it. The World Health Organisation (WHO) is driving change on a global level and will table a pandemic preparedness plan at the next World Health Assembly. Preparing now, during the interpandemic period, is the best way to prepare for a pandemic.









Has Abstract


2006-11-10 00:00:00
















  • Whole inactivated avian Influenza H9N2 viruses induce nasal submucosal dendritic cells to sample luminal viruses via transepithelial dendrites and trigger subsequent DC maturation.

    abstract::Nasal mucosal barrier is a key impediment for the absorption of influenza whole inactivated virus (WIV) intranasal vaccine. Yet it is still unclear how WIV cross the epithelial cells (ECs) in nasal cavity. Here, in vitro, a coculture system was well established, consisting of surrogate nasal ECs (Calu-3) and dendritic...


    pub_type: 杂志文章


    authors: Qin T,Yin Y,Wang X,Liu H,Lin J,Yu Q,Yang Q

    更新日期:2015-03-10 00:00:00

  • Needle-free delivery of DNA: Targeting of hemagglutinin to MHC class II molecules protects rhesus macaques against H1N1 influenza.

    abstract::Conventional influenza vaccines are hampered by slow and limited production capabilities, whereas DNA vaccines can be rapidly produced for global coverage in the event of an emerging pandemic. However, a drawback of DNA vaccines is their generally low immunogenicity in non-human primates and humans. We have previously...


    pub_type: 杂志文章


    authors: Mooij P,Grødeland G,Koopman G,Andersen TK,Mortier D,Nieuwenhuis IG,Verschoor EJ,Fagrouch Z,Bogers WM,Bogen B

    更新日期:2019-02-04 00:00:00

  • Bacillus subtilis spores as adjuvants for DNA vaccines.

    abstract::Recently, Bacillus subtilis spores were shown to be endowed with strong adjuvant capacity when co-administered with purified antigenic proteins. In the present study we assessed whether spores possess adjuvant properties when combined with DNA vaccines. We showed that B. subtilis spores promoted the activation of dend...


    pub_type: 杂志文章


    authors: Aps LR,Diniz MO,Porchia BF,Sales NS,Moreno AC,Ferreira LC

    更新日期:2015-05-11 00:00:00

  • Early disappearance of maternal anti-measles, mumps, rubella, and varicella antibodies in Indian infants.

    abstract:BACKGROUND:Immunization of children with vaccines against Measles, Mumps, Rubella, and Varicella (MMRV) is practiced globally with varied recommendations. In India, measles vaccine is administered alone or as MMR at 9 months age. Varicella vaccine is not routinely used. Immunization age is a function of disappearance o...


    pub_type: 杂志文章


    authors: Malshe N,Palkar S,Kulkarni R,Lalwani S,Mishra AC,Arankalle V

    更新日期:2019-03-07 00:00:00

  • Use of administrative records to assess pneumococcal conjugate vaccine impact on pediatric meningitis and pneumonia hospitalizations in Rwanda.

    abstract:BACKGROUND:Ongoing surveillance is critical to assessing pneumococcal conjugate vaccine (PCV) impact over time. However, robust prospective studies are difficult to implement in resource-poor settings. We evaluated retrospective use of routinely collected data to estimate PCV impact in Rwanda. METHODS:We collected dat...


    pub_type: 杂志文章


    authors: Gatera M,Uwimana J,Manzi E,Ngabo F,Nwaigwe F,Gessner BD,Moïsi JC

    更新日期:2016-10-17 00:00:00

  • Transcutaneous vaccination with virus-like particles.

    abstract::Virus-like particles (VLP) are inert, empty capsids of viruses, which contain no DNA/RNA from the virus itself. However they retain the structure of a virus and they can be engineered to have antigens attached. We have constructed VLP, derived from Rabbit hemorrhagic disease virus, and shown they are highly immunogeni...


    pub_type: 杂志文章


    authors: Young SL,Wilson M,Wilson S,Beagley KW,Ward V,Baird MA

    更新日期:2006-06-29 00:00:00

  • Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitis.

    abstract::In some cases of atopic dermatitis (AD), a possible pathological contribution to disease development by Candida albicans (C. albicans) has been suggested. AD patients with severe symptoms showing positive capsulated hydrolic carrier polymer radioallergosorbent test (CAP-RAST) against C. albicans demonstrated significa...


    pub_type: 杂志文章


    authors: Suenobu N,Kweon MN,Kiyono H

    更新日期:2002-07-26 00:00:00

  • Immunogenicity and protective efficacy of novel Mycobacterium tuberculosis antigens.

    abstract::With tuberculosis continuing to be a major cause of global morbidity and mortality, a new vaccine is urgently needed. Tuberculosis subunit vaccines have been shown to induce robust immune responses in humans and are a potentially safer alternative to BCG for use in HIV-endemic areas. In this study, we investigated the...


    pub_type: 杂志文章


    authors: Derrick SC,Yabe IM,Yang A,Kolibab K,Hollingsworth B,Kurtz SL,Morris S

    更新日期:2013-09-23 00:00:00

  • The PGRS domain of Mycobacterium tuberculosis PE_PGRS Rv1759c antigen is an efficient subunit vaccine to prevent reactivation in a murine model of chronic tuberculosis.

    abstract::A third of the world population is latently infected with Mycobacterium tuberculosis and many cases of active tuberculosis arise from latent bacilli reactivation. Thus, it is important to design new vaccines to prevent reactivation. Using an experimental model of chronic tuberculosis in B6D2F1 mice, we observed consta...


    pub_type: 杂志文章


    authors: Campuzano J,Aguilar D,Arriaga K,León JC,Salas-Rangel LP,González-y-Merchand J,Hernández-Pando R,Espitia C

    更新日期:2007-05-04 00:00:00

  • Long-term follow-up: no effect of therapeutic vaccination with HIV-1 p17/p24:Ty virus-like particles on HIV-1 disease progression.

    abstract::Long-term effects of therapeutic vaccination of human immunodeficiency virus (HIV)-1-infected subjects with HIV-1 p17/p24:Ty virus-like particles (p24-VLP) on progression to AIDS, death, a CD4 cell count


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Lindenburg CE,Stolte I,Langendam MW,Miedema F,Williams IG,Colebunders R,Weber JN,Fisher M,Coutinho RA

    更新日期:2002-05-22 00:00:00

  • Monitoring the uptake of live avian vaccines by their detection in feathers.

    abstract::Protection against diseases caused by the avian viruses, Marek's disease, Infectious laryngotracheitis, chicken anemia and turkey meningoencephalitis is achieved by live vaccines. The application quality is important to assure proper uptake in commercial flocks. We describe a novel evaluation method for the vaccinatio...


    pub_type: 杂志文章


    authors: Davidson I,Natour-Altory A,Raibstein I,Kin E,Dahan Y,Krispin H,Elkin N

    更新日期:2018-01-29 00:00:00

  • Treatment of cervical cancer in Italy: strategies and their impact on the women.

    abstract::Treatment of cervical cancer greatly varies according to the stage of the disease. Laparoscopic surgical staging is emerging as a valid approach, compared to clinical and imaging staging, to better identify the treatment plan. Minimally invasive surgery plays the greatest role in the treatment of early cervical carcin...


    pub_type: 杂志文章,评审


    authors: De Vincenzo R,Amadio G,Ricci C,Licameli A,Ferrandina G,Capelli G,Scambia G

    更新日期:2009-05-29 00:00:00

  • A randomized controlled trial of an online immunization curriculum.

    abstract:INTRODUCTION:Immunization education for physicians-in-training is crucial to address vaccine concerns in clinical practice. Vaccine education is not standardized across residency programs. The Collaboration for Vaccination Education and Research (CoVER) team developed an online curriculum for pediatric (Peds) and famil...


    pub_type: 杂志文章


    authors: Pahud B,Elizabeth Williams S,Lee BR,Lewis KO,Middleton DB,Clark S,Humiston SG

    更新日期:2020-10-27 00:00:00

  • Avipox-based simian immunodeficiency virus (SIV) vaccines elicit a high frequency of SIV-specific CD4+ and CD8+ T-cell responses in vaccinia-experienced SIVmac251-infected macaques.

    abstract::The ability of ALVAC- or fowlpox-based simian immunodeficiency virus (SIV) vaccines to boost SIV-specific CD4+ and CD8+ T-cell responses was tested in 10 vaccinia-experienced macaques infected with SIVmac251. The CD8+ T-cell response to the dominant Gag(181-189) CM9 was quantitated in seven Mamu-A*01-positive macaques...


    pub_type: 杂志文章


    authors: Nacsa J,Radaelli A,Edghill-Smith Y,Venzon D,Tsai WP,Morghen Cde G,Panicali D,Tartaglia J,Franchini G

    更新日期:2004-01-26 00:00:00

  • Knowledge, attitudes and beliefs related to seasonal influenza vaccine among pregnant women in Thailand.

    abstract:BACKGROUND:In 2009, Thailand recommended pregnant women be prioritized for influenza vaccination. Vaccine uptake among Thai pregnant women is lower than other high-risk groups. METHODS:During December 2012-April 2013, we conducted a cross-sectional survey of a convenience sample of Thai pregnant women aged ≥ 15 years ...


    pub_type: 杂志文章


    authors: Ditsungnoen D,Greenbaum A,Praphasiri P,Dawood FS,Thompson MG,Yoocharoen P,Lindblade KA,Olsen SJ,Muangchana C

    更新日期:2016-04-19 00:00:00

  • Comparative vaccine efficacy of different isoforms of recombinant protective antigen against Bacillus anthracis spore challenge in rabbits.

    abstract::The next-generation human anthrax vaccine developed by the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) is based upon purified Bacillus anthracis recombinant protective antigen (rPA) adsorbed to aluminum hydroxide adjuvant (Alhydrogel). In addition to being safe, and effective, it is...


    pub_type: 杂志文章


    authors: Ribot WJ,Powell BS,Ivins BE,Little SF,Johnson WM,Hoover TA,Norris SL,Adamovicz JJ,Friedlander AM,Andrews GP

    更新日期:2006-04-24 00:00:00

  • Glutamate-rich protein (GLURP) induces antibodies that inhibit in vitro growth of Plasmodium falciparum in a phase 1 malaria vaccine trial.

    abstract::The glutamate-rich protein (GLURP) of P. falciparum is the target of cytophilic antibodies which are significantly associated with protection against clinical malaria. A phase 1 clinical trial was conducted in healthy adult volunteers with the long synthetic peptide (LSP) GLURP(85-213) combined with either Aluminum Hy...


    pub_type: 杂志文章


    authors: Hermsen CC,Verhage DF,Telgt DS,Teelen K,Bousema JT,Roestenberg M,Bolad A,Berzins K,Corradin G,Leroy O,Theisen M,Sauerwein RW

    更新日期:2007-04-12 00:00:00

  • Seroprevalence of Bordetella pertussis antibodies and anti-pertussis antibody response after a single dose of reduced-antigen combined diphtheria, tetanus, and acellular pertussis vaccine (Tdap) in pregnant Thai women.

    abstract:BACKGROUND:Maternal immunization with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) has recently been implemented to prevent infant pertussis. Tdap is still not routinely recommended in Thailand, and there are limited data to support or challenge this strategy. OBJECTIVES:The primar...


    pub_type: 杂志文章


    authors: Sompagdee N,Anuwutnavin S,Phongsamart W,Senawong S,Umrod P,Robkhonburi A

    更新日期:2020-03-10 00:00:00

  • The expected emotional benefits of influenza vaccination strongly affect pre-season intentions and subsequent vaccination among healthcare personnel.

    abstract:BACKGROUND:The relative importance of different attitudes in predicting vaccination among healthcare personnel (HCP) is unclear. We hypothesized that HCP who feel at risk without vaccination or say they would regret not getting vaccinated would be more likely to get vaccinated than HCP who do not expect these emotional...


    pub_type: 杂志文章


    authors: Thompson MG,Gaglani MJ,Naleway A,Ball S,Henkle EM,Sokolow LZ,Brennan B,Zhou H,Foster L,Black C,Kennedy ED,Bozeman S,Grohskopf LA,Shay DK

    更新日期:2012-05-21 00:00:00

  • Genetic to genomic vaccination.

    abstract::Our development of genetic immunization (unfortunately named 'DNA'-immunization at times) seems to have great promise as a vaccine delivery system. However, one is still left with the often formidable problem of discovering what gene of the pathogen to include in the genetic immunization vector. The is particularly a ...


    pub_type: 杂志文章


    authors: Johnston SA,Barry MA

    更新日期:1997-06-01 00:00:00

  • A DNA vaccine encoding genetic fusions of carcinoembryonic antigen (CEA) and granulocyte/macrophage colony-stimulating factor (GM-CSF).

    abstract::The anti-tumor immunologic effects of plasmid DNA vaccines encoding human carcinoembryonic antigen (CEA) fused to mouse granulocyte/macrophage colony-stimulating factor (GM-CSF) were examined. Immunization of C57BL/6 mice with the CEA-GMCSF fusion plasmids in a three injection, high-dose immunization schedule led to T...


    pub_type: 杂志文章


    authors: Lima J,Jenkins C,Guerrero A,Triozzi PL,Shaw DR,Strong TV

    更新日期:2005-01-26 00:00:00

  • Enhancement of the protective efficacy of a Chlamydia trachomatis recombinant vaccine by combining systemic and mucosal routes for immunization.

    abstract::Chlamydia trachomatis causes respiratory and sexually transmitted infections. Here, we tested a vaccine formulated with the recombinant major outer membrane protein from C. trachomatis mouse pneumonitis (CT-MoPn) for its ability to protect mice against an intranasal (i.n.) challenge. The adjuvants CpG and Montanide we...


    pub_type: 杂志文章


    authors: Ralli-Jain P,Tifrea D,Cheng C,Pal S,de la Maza LM

    更新日期:2010-11-10 00:00:00

  • Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp.

    abstract::In chronic Hepatitis B Virus (HBV) infection the function of dendritic cells (DC), T- and B-cells is impaired. DC vaccination is an option to overcome this. DC pulsed in vitro with HBV sub viral particles (HBVsvp) and used to immunize mice can activate HBV directed humoral and cellular immune responses. In the present...


    pub_type: 杂志文章


    authors: Farag MM,Tedjokusumo R,Flechtenmacher C,Asen T,Stremmel W,Müller M,Protzer U,Weigand K

    更新日期:2012-09-14 00:00:00

  • Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients.

    abstract::Heat shock proteins (HSP) are highly conserved molecules that play important roles in protein folding, assembly of protein complexes and translocation of proteins across cellular compartments, as well as in several immunological processes. In this study, we first immunized susceptible BALB/c and resistant C57BL/6 mice...


    pub_type: 杂志文章


    authors: Rafati S,Gholami E,Hassani N,Ghaemimanesh F,Taslimi Y,Taheri T,Soong L

    更新日期:2007-05-22 00:00:00

  • Process development for the mass production of Ehrlichia ruminantium.

    abstract::This work describes the optimization of a cost-effective process for the production of an inactivated bacterial vaccine against heartwater and the first attempt to produce the causative agent of this disease, the rickettsia Ehrlichia ruminantium (ER), using stirred tanks. In vitro, it is possible to produce ER using c...


    pub_type: 杂志文章


    authors: Marcelino I,Sousa MF,Veríssimo C,Cunha AE,Carrondo MJ,Alves PM

    更新日期:2006-03-06 00:00:00

  • Beneficiary characteristics and vaccinations in the end-stage renal disease Medicare beneficiary population, an analysis of claims data 2006-2015.

    abstract:BACKGROUND:The Advisory Committee on Immunization Practices (ACIP) routinely recommends three vaccines - influenza, hepatitis B, and pneumococcal vaccines - for End-Stage Renal Disease (ESRD) dialysis patients. METHODS:We sought to assess vaccination coverage among fee-for-service (FFS) Medicare beneficiaries with ESR...


    pub_type: 杂志文章


    authors: Shen AK,Kelman JA,Warnock R,Zhang W,Brereton S,McKean S,Wernecke M,Chu S,Gellin BG

    更新日期:2017-12-19 00:00:00

  • Evaluation of pneumococcal meningitis clusters in Burkina Faso and implications for potential reactive vaccination.

    abstract:BACKGROUND:To better understand how to prevent and respond to pneumococcal meningitis outbreaks in the meningitis belt, we retrospectively examined Burkina Faso's case-based meningitis surveillance data for pneumococcal meningitis clusters and assessed potential usefulness of response strategies. METHODS:Demographic a...


    pub_type: 杂志文章


    authors: Soeters HM,Kambiré D,Sawadogo G,Ouédraogo-Traoré R,Bicaba B,Medah I,Sangaré L,Ouédraogo AS,Ouangraoua S,Yaméogo I,Congo-Ouédraogo M,Ky Ba A,Aké F,Velusamy S,McGee L,Van Beneden C,Whitney CG

    更新日期:2020-07-31 00:00:00

  • Efficacy of immunotherapy using antigens of Pythium insidiosum in the treatment of vascular pythiosis in humans.

    abstract::Human pythiosis is an emerging disease in the tropical, subtropical and temperate regions of the world. It is caused by the straminipilan, fungus-like, aquatic organism Pythium insidiosum. Pythiosis occurs in localized as well as systemic or vascular forms. Most patients with arterial pythiosis usually have underlying...


    pub_type: 杂志文章


    authors: Wanachiwanawin W,Mendoza L,Visuthisakchai S,Mutsikapan P,Sathapatayavongs B,Chaiprasert A,Suwanagool P,Manuskiatti W,Ruangsetakit C,Ajello L

    更新日期:2004-09-09 00:00:00

  • Critical prevalence of antibodies minimizing vaccination costs for hepatitis A, hepatitis B, varicella, measles and tetanus in adults and adolescents in Catalonia, Spain.

    abstract::The prevalence of seropositive individuals that makes costs of vaccinating all individuals equal to that for screening and vaccination of susceptible individuals is defined as the critical prevalence of antibodies (p*). Screening and vaccination is more efficient when the prevalence of seropositive individuals (p) in ...


    pub_type: 杂志文章


    authors: Plans-Rubió P

    更新日期:2004-09-28 00:00:00

  • Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens.

    abstract::In this study, we compare four different adjuvants, LT(R192G), CpG ODN, MPL((R))TDM, and alum, for their ability to affect the magnitude, distribution, and duration of antibody responses against F1-V, the lead-candidate antigen for the next generation vaccine against plague, in a murine model. In addition, three diffe...


    pub_type: 杂志文章


    authors: Uddowla S,Freytag LC,Clements JD

    更新日期:2007-11-19 00:00:00