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Protection against establishment of latent infections in mice immunized with a non-pathogenic herpes simplex virus mutant and reinfected with the pathogenic parental strain.

Abstract：

:Immunization of hairless mice with a TK-, ACVr, non-pathogenic herpes simplex virus (HSV) type 1 mutant protected the mice against reinfection with lethal doses of the parental pathogenic HSV strain. The protection conferred by the mutant against the establishment of latency after reinfection with the parental strain was dependent on the site of reinfection; after reinfection at the same site, only 2% of mice became latently infected, compared to 32% after reinfection at a distant site. When inoculation with the mutant was done at two different sites, single reinfections at any site led to the establishment of latency in 4% of the mice. The mutant by itself was almost completely latency-negative: only 4.5% of the mice developed latency in trigeminal ganglia and 2.3% in the spinal ganglia. The rate of mutant-induced latent infections is partly related to the dose of the virus; however, lower doses of the mutant may not colonize the ganglia, and therefore fail to protect against challenge infections.

journal_name

Vaccine

journal_title

Vaccine

authors

Klein RJ,Kaley LA,Friedman-Kien AE

doi

10.1016/0264-410x(84)90089-6

subject

Has Abstract

pub_date

1984-09-01 00:00:00

pages

219-23

issue

3

eissn

0264-410X

issn

1873-2518

pii

0264-410X(84)90089-6

journal_volume

2

pub_type

杂志文章

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