Abstract：
:This study compared the safety and immunogenicity of DTaP₅-IPV-Hib vaccine (followed by monovalent hepatitis B vaccine [HBV]) and DTaP₃-HBV-IPV/Hib vaccines, both coadministered with PCV7, as a fourth-dose booster in toddlers 11-18 months who had a hexavalent vaccine primary series. The fever rate within 4 days of DTaP₅-IPV-Hib was noninferior to DTaP₃-HBV-IPV/Hib. DTaP₅-IPV-Hib induced a marked immune response and had a similar safety and immunogenicity profile compared with DTaP₃-HBV-IPV/Hib. Fully liquid DTaP₅-IPV-Hib can be used as a booster after a hexavalent vaccine primary series; where required, a fourth dose of monovalent HBV can be administered after DTaP₅-IPV-Hib (NCT ID: NCT00355654).
journal_name
Vaccinejournal_title
Vaccineauthors
Berner R,Boisnard F,Thomas S,Mwawasi G,Reynolds Ddoi
10.1016/j.vaccine.2012.05.064subject
Has Abstractpub_date
2012-07-27 00:00:00pages
5270-7issue
35eissn
0264-410Xissn
1873-2518pii
S0264-410X(12)00816-Xjournal_volume
30pub_type
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